Results 81 to 90 of about 94,567 (312)

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis.

, 2002
beta-catenin is involved in E-cadherin-mediated cell adhesion, intracellular signal transduction, and also interacts with adenomatous polyposis coli (APC) protein.
Tomlinson, IP, Frayling, I.M., Hao, X, Han, W., Frayling, IM, Talbot, Ian C., Willcocks, T.C., Willocks, T., Hao, Xingpei, Tomlinson, Ian P., Pretlow, T.P., Pignatelli, M.N., Talbot, I.C., Frayling, Ian Martin, Han, W, Tomlinson, I.P.M., Pignatelli, Massimo N., Pignatelli, MN, Willcocks, TC, Han, Wei, Pretlow, Theresa P., Pretlow, TP, Hao, X., Willcocks, Teresa C., Talbot, IC   +24 more
core   +1 more source

Differential Regulation of Growth-Promoting Signalling Pathways by E-Cadherin [PDF]

, 2010
Background: Despite the well-documented association between loss of E-cadherin and carcinogenesis, as well as the link between restoration of its expression and suppression of proliferation in carcinoma cells, the ability of E-cadherin to modulate growth-
Dawn C Walker, Kirkwood, L.A., Lisa A Kirkwood, Dawn C. Walker, Georgopoulos, N.T., Lisa A. Kirkwood, Kirkwood Lisa A., Jennifer Southgate, Georgopoulos, Nikolaos T., Walker, Dawn C., Walker, D.C., Georgopoulos Nikolaos T., Nikolaos T. Georgopoulos, Kirkwood, Lisa A., Southgate, Jennifer, Southgate, J., Southgate Jennifer, Nikolaos T Georgopoulos, Walker Dawn C.   +18 more
core   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

The presence of alpha-catenin in the VE-cadherin complex is required for efficient transendothelial migration of leukocytes

International Journal of Biological Sciences, 2009
The majority of the leukocytes cross the endothelial lining of the vessels through cell-cell junctions. The junctional protein Vascular Endothelial (VE)-cadherin is transiently re-distributed from sites of cell-cell contacts during passage of leukocytes.
Jaap D. van Buul, Floris P. van Alphen, Peter L. Hordijk
doaj  

Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal [PDF]

, 2006
In Xenopus, the establishment of the anteroposterior axis involves two key signalling pathways, canonical Wnt and Nodal-related TGFbeta. There are also a number of transcription factors that feedback upon these pathways.
Gardner, Clare E, Clare E. Gardner, Geoffrey I. Johnston, Brickman, Joshua M, Andrea L. Zamparini, Tim Watts, Zamparini, Andrea L, Tomlinson, Simon R, Watts, Tim, Joshua M. Brickman, Johnston, Geoffrey I, Simon R. Tomlinson   +11 more
core   +1 more source

Emerging Direct Targeting β-Catenin Agents

, 2022
Aberrant accumulation of β-catenin in the cell nucleus as a result of deregulation of the Wnt/β-catenin pathway is found in various types of cancer.
Marianna Nalli, Masci, Domiziana, Silvestri, Romano, Domiziana Masci, Romano Silvestri, La Regina, Giuseppe, Giuseppe La Regina, Urbani, Andrea, Andrea Urbani, Nalli, Marianna   +9 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

An immunohistochemical study of beta-catenin in HNPCC colon tumours

, 2004
Includes bibliographical references (leaves 49-55).Beta-catenin is normally complexed with adenomatous polyposis coli (APC) protein and E-cadherin adhesion molecule, and localized on the cell membrane.
Watkins, Jennifer G
core  

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source