Results 221 to 230 of about 163,662 (341)

Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis. [PDF]

Nat Commun, 2023
Ding D, Blee AM, Zhang J, Pan Y, Becker NA, Maher LJ, Jimenez R, Wang L, Huang H.   +8 more
europepmc   +1 more source

Prognostic Impact of Histologic Subtypes in Mismatch Repair‐Deficient/Microsatellite Instability‐High Colorectal Cancer: A Single‐Center Retrospective Study of 1127 Stage 0–IV Patients

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Deficient mismatch repair/microsatellite instability‐High (dMMR/MSI‐H) colorectal cancer (CRC) generally confers a favorable survival yet is paradoxically enriched for poorly differentiated (Por) histology, which is linked to aggressive behavior.
Tomoyuki Momma, Hirokazu Okayama, Sohei Hayashishita, Hiroya Suzuki, Masanori Katagata, Takuro Matsumoto, Daisuke Ujiie, Shun Chida, Wataru Sakamoto, Koji Kono   +9 more
wiley   +1 more source

Evaluation of Immunohistochemical Expression of Beta-catenin and E-cadherin as Epithelial-Mesenchymal Transition Markers in Colorectal Carcinoma - An Analytical Retrospective Study in a Tertiary Care Center. [PDF]

Int J Appl Basic Med Res
Katta R, Nugala S, Kolakonda M, Chinnam A.   +3 more
europepmc   +1 more source

Melatonin and andrographolide synergize to inhibit the colospheroid phenotype by targeting Wnt/beta-catenin signaling. [PDF]

J Pineal Res, 2022
Sokolov D, Sharda N, Giri B, Hassan MS, Singh D, Tarasiewicz A, Lohr C, von Holzen U, Kristian T, Waddell J, Reiter RJ, Ahmed H, Banerjee A.   +12 more
europepmc   +1 more source

IL-21-secreting hUCMSCs combined with miR-200c inhibit tumor growth and metastasis via repression of Wnt/β-catenin signaling and epithelial-mesenchymal transition in epithelial ovarian cancer

, 2018
Yunxia Zhang, Jing Wang, Di Wu, Miao Li, Fengshu Zhao, Mulan Ren, Yunlang Cai, Jun Dou   +7 more
openalex   +2 more sources

Ethanolic Extract of Traditional Chinese Medicine (TCM) Gamboge Inhibits Colon Cancer via the Wnt/Beta-Catenin Signaling Pathway in an Orthotopic Mouse Model [PDF]

, 2018
Wei Wang, Youran Li, Yiqi Chen, Hongjin Chen, Ping Zhu, Minmin Xu, Hao Wang, Minna Wu, Zhijian Yang, Robert M. Hoffman, Yunfei Gu   +10 more
openalex   +1 more source

Differential Prognostic Impact of Prior Cholecystectomy Between Proximal and Distal Colorectal Cancer: A 12‐Year Retrospective Cohort Study of 3487 Consecutive Patients

Annals of Gastroenterological Surgery, EarlyView.
In this retrospective cohort of 3487 patients with CRC, history of CCY was associated with significantly worse prognosis in patients with proximal CRC but not in those with distal CRC. This differential prognostic impact showed a statistically significant interaction between tumor location and history of CCY and remained robust after PSM.
Masashi Tsunematsu, Koichiro Haruki, Kazuhiro Yanamoto, Takuo Takehana, Shunta Ishizaki, Mitsuru Yanagaki, Yoshihiro Shirai, Kenei Furukawa, Shinji Onda, Toru Ikegami   +9 more
wiley   +1 more source

Differential role of two coactivators, CCAR1 and CARM1, for dysregulated beta-catenin activity in colorectal cancer cell growth and gene expression

, 2015
C Y Ou
openalex   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Orthodontic treatment after occlusal intervention balances osteoblast and osteoclast differentiation via SIRT1 beta catenin signaling in rats with hypofunctional occlusion. [PDF]

Sci Rep
Ji J, Zhou Z, Zhu Y, Wang R, Liu Y.
europepmc   +1 more source