Results 131 to 140 of about 3,133,166 (336)

Biodiversity, community structure and function of biofilms in stream ecosystems [PDF]

, 2015
Multi-species, surface-attached biofilms often dominate microbial life in streams and rivers, where they contribute substantially to biogeochemical processes.
Besemer, Katharina
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Using rarefaction to isolate the effects of patch size and sampling effort on beta diversity

Ecosphere, 2016
Beta diversity describes how species composition varies across space and through time. Current estimators of beta diversity typically ignore the effects of within‐patch sample size, determined jointly by local abundance and sampling effort.
Adrian C. Stier, Benjamin M. Bolker, Craig W. Osenberg   +2 more
doaj   +1 more source

Effects of propidium monoazide (PMA) treatment on mycobiome and bacteriome analysis of cystic fibrosis airways during exacerbation [PDF]

, 2016
Introduction and Purpose : Propidium monoazide (PMA)-pretreatment has increasingly been applied to remove the bias from dead or damaged cell artefacts, which could impact the microbiota analysis by high-throughput sequencing. Our study aimed to determine
Audebert, Christophe, Delhaes, Laurence, Deschaght, Pieter, Loywick, Alexandre, Merlin, Sophie, Nguyen, Linh Do Ngoc, Van daele, Sabine, Vaneechoutte, Mario, Viscogliosi, Eric   +8 more
core   +3 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Deterministic processes drive turnover-dominated beta diversity of breeding birds along the central Himalayan elevation gradient

Avian Research
Beta diversity, the variation of community composition among sites, bridges alpha and gamma diversity and can reveal the mechanisms of community assembly through applying distance-decay models and/or partitioning beta diversity into turnover and ...
Zhifeng Ding, Jianchao Liang, Le Yang, Cong Wei, Huijian Hu, Xingfeng Si   +5 more
doaj   +1 more source

Land use changes in an afrotropical biodiversity hotspot affect stream alpha and beta diversity

Ecosphere, 2016
Land use changes such as deforestation and agricultural expansion strongly affect stream biodiversity, with several studies demonstrating negative impacts on stream alpha diversity. Effects of forest conversion on stream beta diversity are much harder to
V. Fugère, A. Kasangaki, L. J. Chapman
doaj   +1 more source

Broad Line Region Physical Conditions along the Quasar Eigenvector 1 Sequence

, 2010
[Abridged] We compare broad emission line profiles and estimate line ratios for all major emission lines between Ly-alpha and H-beta in a sample of six quasars.
Bachev, Baldwin, Barthel, Bentz, Bon, Bonnell, Boroson, Brotherton, C. A. Negrete, Carswell, Collin, Collin-Souffrin, Collin-Souffrin, Collin-Souffrin, Corbin, Corbin, Corbin, D. Dultzin, Davidson, Denney, Eracleous, Eracleous, Espey, Ferland, Ferland, Ferland, Gaskell, Gaskell, Gaskell, Gaskell, Gezari, Gordon, Halpern, Halpern, Hamann, J. W. Sulentic, Johansson, Juarez, Korista, Korista, Kriss, Krongold, La Mura, Laor, Laor, Lauer, Marconi, Marziani, Marziani, Marziani, Marziani, Marziani, Marziani, Marziani, Marziani, Marziani, Mathews, Mathews, Mathur, Matsuoka, Matsuoka, Morris, Negrete, Netzer, Netzer, P. Marziani, Peterson, Peterson, Punsly, R. Bachev, Rafanelli, Richards, S. Zamfir, Sanders, Sani, Sargent, Schlegel, Shang, Shapovalova, Shemmer, Shields, Small, Snedden, Strateva, Sulentic, Sulentic, Sulentic, Sulentic, Sulentic, Sulentic, Sulentic, Sulentic, Sulentic, Sulentic, Turler, Tytler, Vanden Berk, Vestergaard, Vestergaard, Wang, Wang, Wilkes, Wills, Young, Zamfir, Zamfir, Zhang, Zheng   +107 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source