Results 111 to 120 of about 297,362 (295)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
, 2014 Relationship between environmental distance along the Brazilian Atlantic Forest and (A) geographic distance, (B) taxonomic beta diversity (Sorensen's Index); (C) functional beta diversity (MNTD), (D) functional Sorensen's beta diversity, (E) and ...
Carlos Roberto F. Brandão (543381) +1 more
core +1 more source
Using rarefaction to isolate the effects of patch size and sampling effort on beta diversity
Ecosphere, 2016 Beta diversity describes how species composition varies across space and through time. Current estimators of beta diversity typically ignore the effects of within‐patch sample size, determined jointly by local abundance and sampling effort.
Adrian C. Stier +2 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Land use changes in an afrotropical biodiversity hotspot affect stream alpha and beta diversity
Ecosphere, 2016 Land use changes such as deforestation and agricultural expansion strongly affect stream biodiversity, with several studies demonstrating negative impacts on stream alpha diversity. Effects of forest conversion on stream beta diversity are much harder to
V. Fugère, A. Kasangaki, L. J. Chapman
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Ecography, 2010 The term beta diversity has been used to refer to a wide variety of phenomena. Although all of these encompass some kind of compositional heterogeneity between places, many are not related to each other in any predictable way.
openaire +1 more source
Non-native species drive the global loss of freshwater fish beta-diversity [PDF]
Freshwater ecosystems are facing mounting challenges. The widespread introduction of non-native species, for example, has resulted in the loss of native species and the substantial reconfiguration of diversity patterns across regions.
Julian D. Olden +15 more
core +1 more source