Results 121 to 130 of about 3,421,347 (332)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Impacts of invasive trees on alpha and beta diversity of temperate forest understories

Biological Invasions, 2020
Despite good recognition of distributions and spread mechanisms of the three most invasive trees in Europe ( Prunus serotina , Quercus rubra and Robinia pseudoacacia ), their impacts on forest biodiversity are unevenly recognized. Most studies cover only
M. Dyderski, A. Jagodziński
semanticscholar   +1 more source

Fish beta diversity responses to environmental heterogeneity and flood pulses are different according to reproductive guild

Neotropical Ichthyology, 2018
In floodplain communities, beta diversity is influenced by different factors; however, environmental heterogeneity and floods are believed to be particularly influential.
Ángela Gutiérrez C, Jean Carlo Gonçalves Ortega, Angelo Antonio Agostinho   +2 more
doaj   +1 more source

Diffuse flow environments within basalt- and sediment-based hydrothermal vent ecosystems harbor specialized microbial communities [PDF]

, 2013
Hydrothermal vents differ both in surface input and subsurface geochemistry. The effects of these differences on their microbial communities are not clear.
Campbell, Barbara J., Cary, S. Craig, Lee, Charles Kai-Wu, Polson, Shawn W., Williamson, Shannon J., Wommack, K. Eric, Zeigler Allen, Lisa   +6 more
core   +3 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Hierarchical coexistence of universality and diversity controls robustness and multi-functionality in intermediate filament protein networks [PDF]

, 2007
Proteins constitute the elementary building blocks of a vast variety of biological materials such as cellular protein networks, spider silk or bone, where they create extremely robust, multi-functional materials by self-organization of structures over ...
Markus J. Buehler, Theodor Ackbarow
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Seaweeds in two oceans: beta-diversity [PDF]

, 2017
Several species assembly mechanisms have been proposed to structure ecological communities. We assess the biogeography of seaweeds along 2,900 km of South Africa’s coastline in relation to a thermal gradient produced by the Agulhas Current, and ...
Anderson, Barton, Baselga, Baselga, Baselga, Blanchet, Bolton, Bolton, Bolton, Bolton, Bolton, Bolton, Breeman, Broitman, Byrne, Chave, Couce, Davidar, De Clerck, De Wit, Dormann, Dray, Dray, Fitzpatrick, Graham, Griffiths, Hommersand, Hommersand, Hubbell, Issa, Largier, Lawton, Leaper, Lombard, Lüning, Marlow, McClain, Mead, Melo, Minchin, Nekola, Peres-Neto, Peres-Neto, Potts, Qian, Santelices, Schils, Schlegel, Sink, Smale, Smale, Smit, Soininen, Spalding, Spalding, Stegenga, Stephenson, Straub, Stuart-Smith, Thandar, Tittensor, Tonial, Turpie, Tuya, Tyberghein, van den Hoek, van den Hoek, Verbruggen, Waldron, Waters, Wernberg, Whittaker, Whittaker, Wieters, Zintzen   +74 more
core   +2 more sources

Dispersal enhances beta diversity in nectar microbes

Ecology Letters, 2017
AbstractDispersal is considered a key driver of beta diversity, the variation in species composition among local communities, but empirical tests remain limited. We manipulated dispersal of nectar‐inhabiting bacteria and yeasts via flower‐visiting animals to examine how dispersal influenced microbial beta diversity among flowers.
Rachel L, Vannette, Tadashi, Fukami
openaire   +3 more sources