Results 141 to 150 of about 3,133,166 (336)
G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma [PDF]
, 1992 Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) consist of a nucleotide-binding alpha subunit and a high- affinity complex of beta and gamma subunits.
Gilman, Alfred G. +3 more
core
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Bio-Ecological Diversity vs. Socio-Economic Diversity: A Comparison of Existing Measures [PDF]
This paper aims to enrich the standard toolbox for measuring diversity in economics. In so doing, we compare the indicators of diversity used by economists with those used by biologists and ecologists.
Carole Maignan +3 more
core
Statistical inference of the generation probability of T-cell receptors from sequence repertoires
, 2012 Stochastic rearrangement of germline DNA by VDJ recombination is at the origin of immune system diversity. This process is implemented via a series of stochastic molecular events involving gene choices and random nucleotide insertions between, and ...
A. M. Walczak +18 more
core +1 more source
Correlates of different facets and components of beta diversity in stream organisms
Oecologia, 2019 Recently, community ecology has emphasized the multi-facetted aspects of biological diversity by linking species traits and the environment. Here, we explored environmental correlates of taxonomically-based and traits-based compositional distances using ...
Mariana Perez Rocha +7 more
semanticscholar +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Ecological IndicatorsWetlands in Inner Mongolia provide necessary habitats for many bird species and are considered important for biodiversity conservation. However, studies on spatial variation of bird communities within this region remain limited.
Ling-Ying Shuai +8 more
doaj +1 more source
Exploring a possible correlation between the human oral microbiome and body mass index [PDF]
, 2016 Obesity is a growing health problem in America affecting more than a third of Americans25 and is quickly becoming a global health crisis34. Recently there has been much interest in the possible link between the human gut microbiome and obesity as fecal ...
McDermott, Ivy S
core +2 more sources
Ecography, 2010 The present two‐part review aims to put the different phenomena that have been called “beta diversity” over the years into a common conceptual framework and to explain what each of them measures. The first part (Tuomisto 2010) discussed basic definitions of “beta diversity”. Each arises from a different way of combining a definition of “diversity” with
openaire +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source