Results 81 to 90 of about 297,362 (295)

Genotypic-Phenotypic Diversity in Beta Thalassemia

Mediterranean Journal of Hematology and Infectious Diseases, 2014
The remarkable variability in clinical severity of the thalassemia reflects both genetic and environmental factors. It is becoming apparent that the genetic element involves many loci, some of which are directly involved with the basic defect in globin ...
Ravindra Kumar, Vandana Arya
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Disentangling the beta-diversity in anuran parasite communities

Parasitology, 2020
AbstractThere is great heterogeneity in parasite communities among hosts, understanding the nature and drivers of such variations is still a great scientific quest. Here, we analyse the variation in parasite communities by addressing the following questions: (i) What is the beta-diversity component (nestedness or turnover) that most contributes to beta
Elvira D'Bastiani, Karla M. Campião
openaire   +2 more sources

Additive partitioning of a beta diversity index is controversial [PDF]

Proceedings of the National Academy of Sciences, 2015
A recent study (1) reports the spatial clustering patterns of the global distribution of human infectious diseases. However, there are some controversial issues that arise from the beta diversity partitioning method used in the paper. To further debate these issues, we follow the same notations in the paper (1) by writing the Sorensen beta diversity ...
Youhua, Chen, Dénes, Schmera
openaire   +2 more sources

Diversity Oriented Clicking: Synthesis of beta-Substituted Alkenyl Sulfonyl Fluorides as Covalent Human Neutrophil Elastase Inhibitors

, 2022
Diversity Oriented Clicking (DOC) is a discovery method geared towards the rapid synthesis of functional libraries. It combines the best attributes of both classical and modern click chemistries. DOC strategies center upon the chemical diversification of
Yunfei, Cheng, John R. , Cappiello, Stefano, Forli, Seiya, Kitamura, Joshua A., Homer, K. Barry, Sharpless, Jordan L., Woehl, Gencheng , Li, Giulia, Bianco, Dennis W., Wolan, Christopher J. , Smedley, Marie-Claire, Giel, John E., Moses   +12 more
core   +1 more source

Effect of Disturbance Regime on Alpha and Beta Diversity of Rock Pools

Diversity, 2013
Measures of alpha diversity are more frequently used to detect environmental changes and subsequent impacts on biodiversity, while measures based on variability (beta diversity) are said to be more appropriate for detecting those impacts. Theory predicts
Annie Séguin, Dominique Gravel, Philippe Archambault   +2 more
doaj   +1 more source

Plant diversity predicts beta but not alpha diversity of soil microbes across grasslands worldwide

, 2015
Aboveground-belowground interactions exert critical controls on the composition and function of terrestrial ecosystems, yet the fundamental relationships between plant diversity and soil microbial diversity remain elusive.
McCulley, Rebecca L., Harpole, W Stanley, Knops, Johannes MH, Prober, Suzanne M, La Pierre, Kimberly J, MacDougall, Andrew S., Borer, Elizabeth T, Williams, Ryan J., Mitchell, Charles M., Risch, Anita C., Williams, Ryan J, Seabloom, Eric W, McCulley, Rebecca L, Hofmockel, Nicole, Harpole, W. Stanley, Prober, Suzanne M., Lind, Eric M, La Pierre, Kimberly J., DeCrappeo, Nicole M., La Pierre, Kimberly, Firn, Jennifer, Bakker, Jonathan D., Hofmockel, Kirsten S, Mitchell, Charles E., Leff, Jonathan W, Cleland, Elsa E., Mitchell, Charles E, Risch, Anita C, Schuetz, Martin, Adler, Peter B, Stevens, Carly J., Hagenah, Nicole, Leff, Jonathan W., DeCrappeo, Nicole M, Fierer, Noah, MacDougall, Andrew S, Knops, Johannes M. H., Kirkman, Kevin P., Hautier, Yann, Lind, Eric M., Stevens, Carly J, Bakker, Jonathan D, Cleland, Elsa E, Bates, Scott T, Adler, Peter B., Leff, Jonathon M., Borer, Elizabeth T., Seabloom, Eric W., Knops, Johannes M.H., Bates, Scott T., Hofmockel, Kirsten S., Kirkman, Kevin P, DeLorenze, Elizabeth   +52 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Different facets of alpha and beta diversity of benthic diatoms along stream watercourse in a large near‐natural catchment

Ecology and Evolution
Understanding the processes and mechanisms that shape the distribution patterns and variations of biodiversity along spatial gradients continues to be a priority for ecological research. We focused on the biodiversity of benthic diatom communities within
Naicheng Wu, Guohao Liu, Xinxin Qi, Zongwei Lin, Yixia Wang, Yaochun Wang, Yuying Li, Collins Oduro, Sangar Khan, Shuchan Zhou, Tianjiang Chu   +10 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source