Results 151 to 160 of about 1,095,525 (267)

Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes. [PDF]

Nat Commun
Martínez-López JA, Lindqvist A, Lopez-Pascual A, Harder A, Chen P, Ngara M, Shcherbina L, Siffo S, Cowan E, Baira SM, Kryvokhyzha D, Karagiannopoulos A, Chriett S, Skene NG, Prasad RB, Lancien M, Johnson PF, Eliasson P, Eliasson L, Louvet C, Spégel P, Muñoz-Manchado AB, Sandberg R, Hjerling-Leffler J, Wierup N.   +24 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Are We Ready With Prevention for Type 1 Diabetes? [PDF]

Diabetes Metab Res Rev
Maines E, Franceschi R, Candia FD, Mozzillo E.   +3 more
europepmc   +1 more source

Some Inequalities for the Beta Function

, 2017
B. Ravi, A. Venkat Lakshmi
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Autoimmune Type 1 Diabetes in the Era of Disease-Modifying Immune Therapy. [PDF]

Diabetes Metab Res Rev
Michels AW, Gottlieb PA, Nelson B, Dayan C.   +3 more
europepmc   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Restoration of pancreatic beta cell identity and autophagy in K_ATP-induced diabetes by intermittent fasting. [PDF]

Diabetologia
Castelblanco E, Shyr ZA, Ramirez-Sotero I, Yan Z, Chen SX, Diwan A, Remedi MS.   +6 more
europepmc   +1 more source

The LIM homeodomain protein ISL1 mediates the function of TCF7L2 in pancreatic beta cells [PDF]

, 2018
Weijuan Shao, Vivian Szeto, Zhuolun Song, Lili Tian, Zhong‐Ping Feng, M. Cristina Nostro, Tianru Jin   +6 more
openalex   +1 more source