Results 181 to 190 of about 2,443,019 (288)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Culture media affects accuracy of prediction of metallo-β-lactamases mediated resistance to imipenem. [PDF]

PLoS One
Chen K, Miller S, Goy K, Lam T, Maeusli M, She R, Spellberg B, Luna B.   +7 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stanford neuromodulation therapy for treatment-resistant depression: a randomized controlled trial confirming efficacy, and an EEG study providing insight into mechanism of action and a potentially predictive biomarker of efficacy. [PDF]

World Psychiatry
Kratter IH, Austelle CW, Lissemore JI, Wada M, Geoly A, Chaiken A, Kaloiani I, Johnson N, Wan S, Kozyr L, Makarewycz E, Wong B, Sridhar M, Espil FM, Bassano N, Kim B, Ehrie J, Maron-Katz A, Tischler C, Nejad R, Batail JM, Phillips AL, Cole EJ, Ford TJ, Bentzley BS, Jo B, Schatzberg AF, Spiegel D, Rolle C, Sahlem GL, Williams NR.   +30 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Resting-state EEG power and machine-learning classification in adult males with gambling disorder. [PDF]

Front Hum Neurosci
Çınaroğlu M, Yılmazer E, Ülker SV, Tarlacı S.   +3 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

On the virtues and limitations of Granger-causal brain connectivity estimate: Critical analysis using neural mass models. [PDF]

Netw Neurosci
Pelle S, Piermaria G, Magosso E, Ursino M.   +3 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Cost-effectiveness analysis of sugemalimab plus chemotherapy for the first-line treatment of advanced gastric cancer or gastroesophageal junction cancer. [PDF]

Hum Vaccin Immunother
Yan C, He J, Lv G, Gao Y, Li J, Diao R.
europepmc   +1 more source