Results 11 to 20 of about 213,023 (309)

Deciphering Risperidone-Induced Lipogenesis by Network Pharmacology and Molecular Validation

Frontiers in Psychiatry, 2022
BackgroundRisperidone is an atypical antipsychotic that can cause substantial weight gain. The pharmacological targets and molecular mechanisms related to risperidone-induced lipogenesis (RIL) remain to be elucidated.
Yun Fu, Ke Yang, Yepei Huang, Yuan Zhang, Shen Li, Shen Li, Wei-Dong Li   +6 more
doaj   +1 more source

Peroxisomal ATP Uptake Is Provided by Two Adenine Nucleotide Transporters and the ABCD Transporters

Frontiers in Cell and Developmental Biology, 2022
Peroxisomes are essential organelles involved in various metabolic processes, including fatty acid β-oxidation. Their metabolic functions require a controlled exchange of metabolites and co-factors, including ATP, across the peroxisomal membrane.
Carlo W. T. van Roermund, Lodewijk IJlst, Nicole Linka, Ronald J. A. Wanders, Hans R. Waterham   +4 more
doaj   +1 more source

TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes. [PDF]

Nat Commun, 2019
Miklas JW, Clark E, Levy S, Detraux D, Leonard A, Beussman K, Showalter MR, Smith AT, Hofsteen P, Yang X, Macadangdang J, Manninen T, Raftery D, Madan A, Suomalainen A, Kim DH, Murry CE, Fiehn O, Sniadecki NJ, Wang Y, Ruohola-Baker H.   +20 more
europepmc   +3 more sources

Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis. [PDF]

PLoS Genetics, 2009
The mitochondrial beta-oxidation system is one of the central metabolic pathways of energy metabolism in mammals. Enzyme defects in this pathway cause fatty acid oxidation disorders.
Ilkka J Miinalainen, Werner Schmitz, Anne Huotari, Kaija J Autio, Raija Soininen, Emiel Ver Loren van Themaat, Myriam Baes, Karl-Heinz Herzig, Ernst Conzelmann, J Kalervo Hiltunen   +9 more
doaj   +1 more source

It takes a village: channeling fatty acid metabolism and triacylglycerol formation via protein interactomes

Journal of Lipid Research, 2019
Diet, hormones, gene transcription, and posttranslational modifications control the hepatic metabolism of FAs; metabolic dysregulation causes chronic diseases, including cardiovascular disease, and warrants exploration into the mechanisms directing FA ...
Rosalind A. Coleman
doaj   +1 more source

Phytanic acid alpha-oxidation: accumulation of 2-hydroxyphytanic acid and absence of 2-oxophytanic acid in plasma from patients with peroxisomal disorders.

Journal of Lipid Research, 1992
A stable isotope dilution method was developed for the measurement of 2-hydroxyphytanic acid and 2-oxophytanic acid in plasma. In plasma from healthy individuals and from patients with Refsum's disease, 2-hydroxyphytanic acid was found at levels less ...
HJ ten Brink, DS Schor, RM Kok, BT Poll-The, RJ Wanders, C Jakobs   +5 more
doaj   +1 more source

Phytochrome A Regulates Carbon Flux in Dark Grown Tomato Seedlings

Frontiers in Plant Science, 2019
Phytochromes comprise a small family of photoreceptors with which plants gather environmental information that they use to make developmental decisions, from germination to photomorphogenesis to fruit development.
Keisha D. Carlson, Sneha Bhogale, Drew Anderson, Lars Tomanek, Andreas Madlung   +4 more
doaj   +1 more source

Mitochondrial and cellular mechanisms for managing lipid excess

Frontiers in Physiology, 2014
Current scientific debates center on the impact of lipids and mitochondrial function on diverse aspects of human health, nutrition and disease, among them the association of lipotoxicity with the onset of insulin resistance in skeletal muscle, and with ...
Miguel A Aon, Niraj eBhatt, Sonia C Cortassa   +2 more
doaj   +1 more source

Ultraviolet Photodetector Based on a Beta-Gallium Oxide/Nickel Oxide/Beta-Gallium Oxide Heterojunction Structure

Sensors, 2023
In this paper, an n–p–n structure based on a β-Ga2O3/NiO/β-Ga2O3 junction was fabricated. The device based on the β-Ga2O3/NiO/β-Ga2O3 structure, as an ultraviolet (UV) photodetector, was compared with a p–n diode based on a NiO/β-Ga2O3 structure, where it showed rectification and 10 times greater responsivity and amplified the photocurrent. The reverse
openaire   +3 more sources

Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr−/− mice

Journal of Lipid Research, 2018
Obesity and its associated metabolic dysfunction and cardiovascular disease risk represent a leading cause of adult morbidity worldwide. Currently available pharmacological therapies for obesity have had limited success in reversing existing obesity and ...
Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Marisa R. Morrow, Cynthia G. Sawyez, Jane Y. Edwards, Maria Drangova, Murray W. Huff   +7 more
doaj   +1 more source