Results 111 to 120 of about 181,428 (336)

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Structural Eigenmodes of the Brain to Improve the Source Localization of EEG: Application to Epileptiform Activity

Advanced Science, EarlyView.
Geometry and connectivity are complementary structures, which have demonstrated their ability to represent the brain's functional activity. This study evaluates geometric and connectome eigenmodes as biologically informed constraints for EEG source localization.
Pok Him Siu, Philippa J. Karoly, Sina Mansour L., Artemio Soto‐Breceda, Levin Kuhlmann, Mark J. Cook, David B. Grayden   +6 more
wiley   +1 more source

Scalp Electroencephalogram-Derived Involvement Indexes during a Working Memory Task Performed by Patients with Epilepsy

Sensors
Electroencephalography (EEG) wearable devices are particularly suitable for monitoring a subject’s engagement while performing daily cognitive tasks. EEG information provided by wearable devices varies with the location of the electrodes, the suitable ...
Erica Iammarino, Ilaria Marcantoni, Agnese Sbrollini, MHD Jafar Mortada, Micaela Morettini, Laura Burattini   +5 more
doaj   +1 more source

Diel pattern of circadian clock and storage protein gene expression in leaves and during seed filling in cowpea (Vigna unguiculata) [PDF]

, 2018
Background Cowpea (Vigna unguiculata) is an important source of protein supply for animal and human nutrition. The major storage globulins VICILIN and LEGUMIN (LEG) are synthesized from several genes including LEGA, LEGB, LEGJ and CVC (CONVICILIN).
Egea Gutiérrez-Cortines, Marcos, Fernández, Juan A., Letourneux, Lisa, Martos Fuentes, Marina Marta, Ruiz Hernández, María Víctoria, Terry López, Marta Isabel, Weiss, Julia Rosl   +6 more
core   +4 more sources

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

A novel deep learning model for objective quantification of generalized anxiety disorder severity using EEG functional connectivity

Frontiers in Psychiatry
Generalized anxiety disorder (GAD) is a prevalent and disabling psychiatric condition, yet its severity is still assessed mainly through clinical interviews and self-report scales, which lack objective neurobiological markers. This study aimed to develop
Xiaodong Luo, Yuhuan Cui, Zihao Yan, Wei Liu, Bin Zhou, Gang Li, Shouqing Liu   +6 more
doaj   +1 more source

Antiarrhythmic drug therapy among patients presenting to emergency department with symptomatic atrial fibrillation – a prospective nationwide cohort

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2017
Background Atrial fibrillation (AF) is a common arrhythmia that causes numerous visits to emergency departments (ED). The aim of the FinFib2 study was to evaluate whether treatment of patients with AF in ED is consistent with the contemporary European ...
Tero Penttilä, Heikki Mäkynen, Juha Hartikainen, Harri Hyppölä, Timo Lauri, Mika Lehto, Juha Lund, MJ Pekka Raatikainen, for the FinFib2 investigators   +8 more
doaj   +1 more source

Cardiovascular changes after administration of aerosolized salbutamol in horses: five cases [PDF]

, 2014
Prevention and treatment of intraoperative hypoxemia in horses is difficult and both efficacy and safety of therapeutic maneuvers have to be taken into account.
AE Wagner, Chiara Adami, Claudia Spadavecchia, Daniela Casoni, E Spiekerkoetter, EM Kallergis, FJ Derksen, G Nyman, G Nyman, G Nyman, H-M Palos, J Horn, JG Baker, JR Dodam, K Toerneke, K Toerneke, KJ Whitehair, KJ Whitehair, L Devisscher, M Patschova, MA Gaballa, MR Bristow, OE Brodde, SA Robertson, YH Lee   +24 more
core   +5 more sources