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Current status of beta‐thalassemia and its treatment strategies
Molecular Genetics & Genomic Medicine, 2021 Thalassemia is an inherited hematological disorder categorized by a decrease or absence of one or more of the globin chains synthesis. Beta‐thalassemia is caused by one or more mutations in the beta‐globin gene.
Shaukat Ali +11 more
semanticscholar +1 more source
Evaluation of Srivastava index to distinguishing Beta-Thalassemia Trait from Iron Deficiency
Pakistan Journal of Medical & Health Sciences, 2022 Objective: To assist in the differential diagnosis of beta thalassemia trait and iron deficiency anaemia, many alternative red blood cell index-based formulae were examined.
Hassnain Shahid +5 more
semanticscholar +1 more source
eJHaem, 2021 The genotype and phenotype correlation between coinheritance of heterozygous beta‐thalassemia with the alpha‐globin triplication is unclear. In this study we have investigated and reviewed alpha triplication frequency in beta‐thalassemia carriers, sickle
Mohammad Hamid +6 more
doaj +1 more source
Thalassemia (Beta-Thalassemia)
International Journal For Multidisciplinary Research, 2023 Thalassemia is an inherited blood disorder characterized by less oxygen carrying protein (Haemoglobin) and fever red blood cells in the body than normal. There are mainly two types of thalassemia i.e. Alpha and Beta thalassemia about 1-5% of the global population 80-90 million people are the carrier of ß thalassemia which is major concern.
Tathe Pratiksha Annasaheb - +2 more
openaire +1 more source
Molecular Genetics & Genomic Medicine, 2020 Background Hepcidin and hemochromatosis (HFE) are iron regulatory proteins that are encoded by HAMP and HFE genes. Mutation in either HAMP gene or HFE gene causes Hepcidin protein deficiency that can lead to iron overload in beta thalassemia patients ...
Maryam Shah +7 more
doaj +1 more source
Pediatric Hematology Oncology Journal, 2023 Introduction: Delta-beta thalassemia and hereditary persistence of fetal hemoglobin (HPFH) results from a deletion in both the delta and beta genes on chromosome 11.
Sneha Waghela +4 more
doaj +1 more source
Advanced Medical Journal, 2022 Background and objectives: The identification of carriers of beta- thalassemia depends on the detection of a high level of hemoglobin A2. The hemoglobin A2 level is influenced by some elements including iron.
Awaz Ahmed Kamal Shalli +2 more
doaj +1 more source
TyG index and insulin resistance in beta-thalassemia [PDF]
, 2015 Insulin resistance (IR) underlies some glucose metabolism abnormalities in thalassemia major. Recently, triglyceride glucose index (TyG) has been proposed for evaluating insulin resistance as a simple, low cost, and accessible tool.
Fayaz, M. +3 more
core +1 more source
Rare Co-occurrence of Beta-Thalassemia and Pseudoxanthoma elasticum: Novel Biomolecular Findings
Frontiers in Medicine, 2020 A number of beta-thalassemia patients, independently from the type of beta-thalassemia (β0 or β+) and blood transfusion requirements, may develop, after puberty, dermal, cardiovascular, and ocular complications associated with an ectopic mineralization ...
F. Boraldi +4 more
semanticscholar +1 more source
.BETA.+-Thalassemia with Hemochromatosis.
Internal Medicine, 1992 A 64-year-old man was admitted due to ascites. Laboratory data showed hemoglobin 6.7 g/dl, mean corpuscular volume 82 fl, and ferritin 2,360 ng/ml. Liver biopsy showed hemochromatosis. The diagnosis of beta-thalassemia was suggested by a decreased ratio of beta/alpha-globin synthesis in vitro (0.26).
Masakatsu UCHIHARA +11 more
openaire +3 more sources