Korean Journal of Family Medicine, 2018 Background Considering the high prevalence of depression and anxiety among thalassemia patients and the role of social support in preventing mental disorders, this study aimed to determine prevalence of depression, anxiety, and perceived social support ...
A. Maheri +5 more
semanticscholar +1 more source
Stem cell research & therapeutics, 2018 BackgroundThalassemia is the most common genetic disease worldwide; those with severe disease require lifelong blood transfusion and iron chelation therapy.
Methichit Wattanapanitch +8 more
semanticscholar +1 more source
Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients [PDF]
, 2017 Background: Human erythropoiesis is characterized by distinct gene expression profiles at various developmental stages. Previous studies suggest that fetal-to-adult hemoglobin switch is regulated by a complex mechanism, in which many key players still ...
Chondrou, Vasiliki +11 more
core +4 more sources
A Study on The Awareness of Consanguinity & Various Genetic Aspects Among the Parents of Children with Beta Thalassemia and To Understand the Usefulness of Various Indices in Identifying Beta Thalassemia Carriers in A Cohort of South Indian Patients [PDF]
, 2023 Background: Beta thalassemia is one of the common single gene disorders in India. Screening relies on High performance Liquid Chromatography (HPLC) / Hemoglobin electrophoresis.
Raj, Revathi +2 more
core +2 more sources
Anthropometric measurements in children having transfusion-dependent beta thalassemia
Hematology, 2018 Objectives: The aim of this study was to determine the anthropometric measurements in transfusion-dependent β-thalassemia children in Pakistan. The secondary aim was to correlate serum ferritin with the physical growth. Methods: We enrolled 367 children (
B. Moiz +5 more
semanticscholar +1 more source
A Strategy analysis for genetic association studies with known inbreeding [PDF]
, 2011 Background: Association studies consist in identifying the genetic variants which are related to a specific disease through the use of statistical multiple hypothesis testing or segregation analysis in pedigrees.
Bertolino, Francesco +9 more
core +2 more sources
Saudi Medical Journal, 2018 Beta-thalassemia is a genetic disorder that is caused by variations in the beta-hemoglobin (HBB) gene. Saudi Arabia is among the countries most affected by beta-thalassemia, and this is particularly problematic in the Eastern regions. This review article
Mousa A. Alaithan +2 more
semanticscholar +1 more source
Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid
Chemistry – A European Journal, EarlyView.This review provides an overview of PNA cellular delivery methods, starting with traditional peptide‐based systems and progressing to advanced approaches using nanoparticles, liposomes, and calixarene. It highlights how these innovative strategies have opened the way for more effective and efficient PNA delivery, ultimately enhancing the potential for ...
Concetta Avitabile +4 more
wiley +1 more source
Effects of vitamin e and zinc supplementation on antioxidants in beta thalassemia major patients [PDF]
, 2011 Objective: In beta thalassemic patients, tissue damage occurs due to oxidative stress and it happens because of the accumulation of iron in the body. This study was conducted to determine the effect of zinc and vitamin E supplementation on antioxidant ...
Aboomardani, M. +5 more
core +1 more source
The effects of group play therapy on self-concept among 7 to 11 year-old children suffering from thalassemia major [PDF]
, 2016 Background: Children suffering from thalassemia have higher levels of depression and lower levels of self-concept. Objectives: The aim of this study was to determine if group play therapy could significantly increase self-concept among children with ...
Dastoorpoor, M. +5 more
core +1 more source