Results 41 to 50 of about 1,014,717 (317)

Overview of Beta-Thalassemia

, 2023
Beta-thalassemias are a group of hereditary blood disorders characterized by anomalies in the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. Three main forms have been described: thalassemia major, thalassemia intermedia, and thalassemia minor.
Oshiokhayamhe, Iyevhobu, Kenneth, Omolumen, Lucky E.,, Joseph, Okobi, Tobechukwu, Raphael, Usoro, Edidiong, A., refetalor Ivie,, A., Ken-Iyevhobu, Benedicta, Omokpo, Victoria, O.   +6 more
openaire   +2 more sources

One-step genetic correction of hemoglobin E/beta-thalassemia patient-derived iPSCs by the CRISPR/Cas9 system

Stem cell research & therapeutics, 2018
BackgroundThalassemia is the most common genetic disease worldwide; those with severe disease require lifelong blood transfusion and iron chelation therapy.
Methichit Wattanapanitch, Nattaya Damkham, Ponthip Potirat, Kongtana Trakarnsanga, Montira Janan, Y. U-pratya, P. Kheolamai, Nuttha Klincumhom, S. Issaragrisil   +8 more
semanticscholar   +1 more source

Serum ferritin and hematological indices in thalassemia minor and nontransfusion dependent hemoghlobinopathy

Iraqi Journal of Hematology, 2021
BACKGROUND: Iron deficiency is not common in thalassemia minor and nontransfusion dependent hemoglobinophaties. The majority of these patients have normal-to-high serum ferritin. OBJECTIVES: The aims of the study were to evaluate serum ferritin levels in
Mehdi Dehghani, Parisa Karimzadeh, Nazanin Azadeh, Alirea Rezvani, Ali Kashkooe   +4 more
doaj   +1 more source

A Strategy analysis for genetic association studies with known inbreeding [PDF]

, 2011
Background: Association studies consist in identifying the genetic variants which are related to a specific disease through the use of statistical multiple hypothesis testing or segregation analysis in pedigrees.
Bertolino, Francesco, Biino, Ginevra, Cabras, Stefano, Castellanos, Maria Eugenia, Casula, Laura, Del Giacco, Stefano, Persico, Ivana, Pirastu, Mario, Pirastu, Nicola, Sassu, Alessandro   +9 more
core   +4 more sources

ANALYSIS OF VITAMIN D LEVELS IN CHILDREN WITH THALASSEMIA BETA [PDF]

, 2022
Background : Beta Thalassemia is a genetic disorder inherited by autosomal recessive and has spread throughout the world, including Indonesia. Beta thalassemia requires lifelong transfusions, which can cause an accumulation of iron in the skin, liver ...
Ganda, Idham Jaya, Gautama, Johan, Ridha, Nadirah Rasyid   +2 more
core   +1 more source

Anthropometric measurements in children having transfusion-dependent beta thalassemia

Hematology, 2018
Objectives: The aim of this study was to determine the anthropometric measurements in transfusion-dependent β-thalassemia children in Pakistan. The secondary aim was to correlate serum ferritin with the physical growth. Methods: We enrolled 367 children (
B. Moiz, A. Habib, S. Sawani, Ahmed Raheem, Bilal Hasan, M. Gangwani   +5 more
semanticscholar   +1 more source

Effects of vitamin e and zinc supplementation on antioxidants in beta thalassemia major patients [PDF]

, 2011
Objective: In beta thalassemic patients, tissue damage occurs due to oxidative stress and it happens because of the accumulation of iron in the body. This study was conducted to determine the effect of zinc and vitamin E supplementation on antioxidant ...
Aboomardani, M., Arefhosseini, S.-R., Joshaghani, H., Keshtkar, A., Rafraf, M., Rashidi, M.   +5 more
core   +1 more source

A comprehensive review of the prevalence of beta globin gene variations and the co-inheritance of related gene variants in Saudi Arabians with beta-thalassemia

Saudi Medical Journal, 2018
Beta-thalassemia is a genetic disorder that is caused by variations in the beta-hemoglobin (HBB) gene. Saudi Arabia is among the countries most affected by beta-thalassemia, and this is particularly problematic in the Eastern regions. This review article
Mousa A. Alaithan, S. Abdulazeez, J. Borgio   +2 more
semanticscholar   +1 more source

Hospitalization causes due to iron overload in beta-Thalassemia in Gorgan, Iran [PDF]

, 2011
Objective: To evaluate causes of hospitalization (due to complications of iron overload and other causes) in beta-Thalassemic patients. Methodology: This study was performed on 244 patients with major beta-Thalassemia admitted in Taleghani hospital of ...
Jahazi, A., Mirbehbahani, N., Rahnama, M.S.   +2 more
core  

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload [PDF]

, 2011
Iron overload is the hallmark of hereditary hemochromatosis and a complication of iron-loading anemias such as β-thalassemia. Treatment can be burdensome and have significant side effects, and new therapeutic options are needed.
Alan Waring, Bo Qiao, Elizabeta Nemeth, Emilio Ramos, Fujita, Gloria C. Preza, Gualdi, Kearney, Lyskov, Michael A. Peralta, Nemeth, Piotr Ruchala, Porter, Rogelio Pinon, Sham, Shantanu Sharma, Tomas Ganz   +16 more
core   +2 more sources