Results 51 to 60 of about 1,044,930 (284)
Iraqi Journal of Hematology, 2021 BACKGROUND: Iron deficiency is not common in thalassemia minor and nontransfusion dependent hemoglobinophaties. The majority of these patients have normal-to-high serum ferritin. OBJECTIVES: The aims of the study were to evaluate serum ferritin levels in
Mehdi Dehghani +4 more
doaj +1 more source
Adaptive Functioning and Psychosocial Problems in Children with Beta Thalassemia Major
Open Access Macedonian Journal of Medical Sciences, 2018 BACKGROUND: Beta thalassemia major is considered one of the serious health problems and the commonest hemoglobinopathy in Egypt that creates a burden not only on health system but also on the affected families and children who become vulnerable to ...
Fatma A. Alzaree +5 more
semanticscholar +1 more source
ChemMedChem, EarlyView.Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali +11 more
wiley +1 more source
Hospitalization causes due to iron overload in beta-Thalassemia in Gorgan, Iran [PDF]
, 2011 Objective: To evaluate causes of hospitalization (due to complications of iron overload and other causes) in beta-Thalassemic patients. Methodology: This study was performed on 244 patients with major beta-Thalassemia admitted in Taleghani hospital of ...
Jahazi, A. +2 more
core
Identification of erythroferrone as an erythroid regulator of iron metabolism. [PDF]
, 2014 Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores.
Ganz, Tomas +5 more
core +1 more source
Impact of the quenching of $g_{\rm A}$ on the sensitivity of $0νββ$ experiments [PDF]
Phys. Rev. C 96, 055501 (2017), 2017 Detection of the neutrinoless $\beta\beta$ ($0\nu\beta\beta$) decay is of high priority in the particle- and neutrino-physics communities. The detectability of this decay mode is strongly influenced by the value of the weak axial-vector coupling constant $g_{\rm A}$.
arxiv +1 more source
Journal of Blood Medicine, 2018 Introduction Beta-thalassemia is a group of inherited hemolytic anemias and one of the most common genetic disorders in Thailand. The clinical spectrum of beta-thalassemia disease ranges from mild to severe clinical symptoms including mild beta ...
C. Traivaree +4 more
semanticscholar +1 more source
Developmental Dynamics, EarlyView.Abstract Disruption of extracellular pH and proton‐sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH‐sensitive fluorescent protein pHluorin2, tethered to
Leif R. Neitzel +5 more
wiley +1 more source
Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload [PDF]
, 2011 Iron overload is the hallmark of hereditary hemochromatosis and a complication of iron-loading anemias such as β-thalassemia. Treatment can be burdensome and have significant side effects, and new therapeutic options are needed.
Alan Waring +16 more
core +2 more sources
Pediatric Hematology Oncology Journal, 2023 Introduction: Delta-beta thalassemia and hereditary persistence of fetal hemoglobin (HPFH) results from a deletion in both the delta and beta genes on chromosome 11.
Sneha Waghela +4 more
doaj