Results 111 to 120 of about 26,664 (228)

Undetectable Hydroxyurea Levels in the Majority of Sickle Cell Disease Patients, Especially in Young Children

American Journal of Hematology, Volume 101, Issue 9, Page 2297-2310, September 2026.
ABSTRACT Hydroxyurea (HU) is the most widely prescribed disease‐modifying treatment in sickle cell disease (SCD), though treatment responses vary due to metabolism and adherence. We examined HU blood levels and treatment response in patients with homozygous sickle cell disease (HbSS).
Sigrid van der Veen, Bart J. Biemond, Marjon H. Cnossen, Pablo Bartolucci, Maria P. Boaro, Betzabel Cajiao Garcia, Raffaella Colombatti, M. D'Agnolo, Karin Fijnvandraat, Anna Collado Gimbert, Amira Idrizovic, Petros Kountouris, Mar Mañú‐Pereira, Elisabetta Mezzalira, Mariane de Montalembert, Erfan Nur, A. Pham Hung D' Alexandry D'Orengiani, Tiziana Sanavia, Saskia E. M. Schols, Marissa J. M. Traets, Minke A. E. Rab, Sara I. Reidel, Anita W. Rijneveld, Yosr Zaouali, Nanda M. Verhoeven‐Duif, Judith J. M. Jans, Eduard J. van Beers   +26 more
wiley   +1 more source

Blunted Serum Erythropoietin Response to Anemia in Patients Polytransfused for Beta-Thalassemia Major [PDF]

, 2008
Purpose: To investigate the response of erythropoietin (EPO) to anemia in patients polytransfused for beta-thalassemia major.Patients and Methods: We measured the serum EPO levels and the concurrent hemoglobin (Hb) concentrations in 40 patients ...
林凱信, LIN, KAI-HSIN
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Association between Alpha- Klotho Protein, Calcium, and Phosphate concentrations in Adult Iraqi Patients with Beta-Thalassemia Major

مجلة كلية الطب
Background: Beta-thalassemia major is a prevalent global condition characterized by a rapid breakdown of red blood cells. Regular blood transfusions can give rise to problems such as cardiovascular disease, diabetes, osteoporosis, and renal disorders ...
Ahmed J. Kadhim, Hedef D. El-Yaseen, Ali M. Jawad   +2 more
doaj   +1 more source

Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion‐Dependent β‐Thalassemia

American Journal of Hematology, Volume 101, Issue 8, Page 1969-1979, August 2026.
ABSTRACT Exagamglogene autotemcel (exa‐cel) is a one‐time, ex vivo, CRISPR‐Cas9 gene edited cell therapy approved for patients with transfusion dependent β‐thalassemia (TDT) aged 12–35 years. In a Phase 3 study (CLIMB THAL‐111), exa‐cel treatment resulted in reactivation of fetal hemoglobin and increases in total hemoglobin, leading to transfusion ...
Sujit Sheth, Selim Corbacioglu, Josu de la Fuente, Mattia Algeri, Joachim Rupprecht, Kevin H. M. Kuo, Ami J. Shah, Peter Lang, Hayley Merkeley, Ben Carpenter, Markus Y. Mapara, Robert I. Liem, Stephan Grupp, Yogi Chopra, Amanda M. Li, Janet L. Kwiatkowski, Melanie Kirby‐Allen, Maria Domenica Cappellini, Antonis Kattamis, Sakellarios Zairis, Tina Liu, William Hobbs, Haydar Frangoul, Franco Locatelli, Roland Meisel, on behalf of the CLIMB THAL‐111 and CLIMB‐131 Study Groups   +25 more
wiley   +1 more source

Clinical Complications of Beta-Thalassemia Major

Iraqi Journal of Pharmaceutical Sciences, 2019
Beata thalassemia Beta thalassemia syndrome by reduction or absence of B-globin chain synthesis. Without iron chelation therapy (ICT) the regular blood transfusion would increase the iron stores to several times.
Ali Jalal Shawkat, Ahmed H. Jwaid
doaj   +1 more source

Knowledge, Attitudes and Practices Toward Hepatitis B Virus Among Transfusion‐Dependent Thalassemia Patients in Jordan

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Knowledge, attitudes, and practices (KAP) studies provide essential insight into public awareness, perceptions, and behaviors toward health issues. Hepatitis B virus (HBV) remains a major public health problem in Jordan. Transfusion‐dependent patients are at higher risk of infection due to frequent exposure to blood products.
Nader Alaridah, Haneen O. Abuhani, Rahaf A. Jereisat, Sara Abu‐Mutaw, Raba'a F. Jarrar, Rayan M. Joudeh, Hasan Nassr, Layan Ismail, Haneen Al‐Abdallat, Anas Y. El‐Massad, Heba Mahmmoud, Anas H. A. Abu‐Humaidan   +11 more
wiley   +1 more source

Assessment of Grades of Recommendations and Applicability of Royal College of Obstetricians and Gynaecologists Green‐Top Guidelines: A Cross‐Sectional Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 9, Page 1771-1776, August 2026.
ABSTRACT Background Royal College of Obstetricians and Gynaecologists (RCOG) Green‐top Guidelines (GTGs) provide evidence‐based recommendations in women's health. Even where evidence is considered high quality, it is uncertain whether factors known to influence maternity outcomes are reflected in study design.
Anangsha Kumar, Alexandra Cocking, Megan Hall, James Morris, Srividhya Sankaran, Holly Lovell, Andrew Shennan, Kypros Nicolaides, Lisa Story   +8 more
wiley   +1 more source

Iron Overload: Pathophysiology, Diagnosis and Monitoring

International Journal of Laboratory Hematology, Volume 48, Issue 4, Page 747-756, August 2026.
ABSTRACT Iron overload is associated with significant health risks, underscoring the importance of understanding its pathophysiology as well as establishing accurate diagnostic and monitoring methods. Chronic iron overload is associated with either genetic disorders characterized by excessive iron accumulation (hereditary hemochromatosis), or is ...
Elena Chatzikalil, Polyxeni Delaporta, Konstantinos Bistas, Antonis Kattamis   +3 more
wiley   +1 more source

Beta Thalassemia Major Bone Marrow Transplant [PDF]

Bone Marrow Transplant is the only possible cure till now for the genetic disorder thalassemia. Thalassemia Major can be managed by regular blood transfusions and iron chelation, but the quality of life is still poor and individuals suffering from this ...
Anand, Ayush
core   +1 more source

Laparoscopic versus open splenectomy in patients with beta thalassemia major [PDF]

, 2006
Background: Laparoscopic splenectomy is considered the standard of care for the removal of the spleen in benign diseases. There are not sufficient data for the routine application of this technique in patients with beta thalassemia major.
Lagoudianakis, E, Gomatos, I, Stamou, KM, Albanopoulos, K, Konstadoulakis, MM, Manouras, A, Antonakis, PT, Leandros, E   +7 more
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