Results 91 to 100 of about 26,664 (228)

Therapeutic Value of Silymarin as Iron Chelator in Children with Beta Thalassemia with Iron Overload

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Beta thalassemia is an inherited hemoglobin disorder resulting in chronic hemolytic anemia. The most common treatment for thalassemia is blood transfusion which is necessary to provide the patients with healthy red blood cells containing normal ...
adel abd elhaleim hagag
doaj  

Multiclass classification of thalassemia types using complete blood count and HPLC data with machine learning

Scientific Reports
Mild to severe anemia is caused by thalassemia, a common genetic disorder affecting over 100 countries worldwide, that results from the abnormality of one or several of the four globin genes. This leads to chronic hemolytic anemia and disrupted synthesis
Muhammad Umar Nasir, Muhammad Zubair, Muhammad Tahir Naseem, Tariq Shahzad, Ahmed Saeed, Khan Muhammad Adnan, Amir H. Gandomi   +6 more
doaj   +1 more source

[Beta thalassemia major in Argentina].

Medicina, 2002
An analysis of beta thalassemia major patients seen at Hospital Juan P. Garrahan was carried out in order to determine the characteristics and outcome of the population. From August 1987 to July 2000, 45 patients were admitted (27 males-18 females). The most common beta globin gene defects were C-39 (30.7%); IVS-I nt 110 (20%); IVS-I nt 6 (13.3%); IVS ...
Feliu Aurora, Torres, Mariana, Bonduel, Gabriela, Sciuccati, Ana, del Pozo, Ariel, Roldán, Marta, Ciaccio, Virginia, Orazi, Virginia, Fano, Blanca, Ozuna, Horacio, Lejarraga, Sackmann Federico, Muriel   +10 more
openaire   +1 more source

Is There a Difference in Occurrence of Complications Between Adults With Hemoglobin SS and Hemoglobin SC Disease: An Extended Systematic Review

European Journal of Haematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is characterized by both acute and chronic complications. The clinical manifestation of these complications differs between genotypes. Given the large amount of research already published, this systematic review aims to offer a complete overview of types of sickle cell complications between adults in the most common ...
Martijn van der Meer, Kim Velsink, Wing H. Tong, Jan W. Schoones   +3 more
wiley   +1 more source

Neutrophil apoptosis in patients with beta-thalassemia major [PDF]

, 2003
Increased susceptibility to infection is reported in patients with beta-thalassemia major due to toxic effect of iron on neutrophil functions and reticuloendothelial system dysfunction.
Ateş, Halil, Oren, Hale, Yaprak, I, Iken, G, Duman, Murat, Yilmaz, ŞEBNEM, Turker, M, Atabay, B, Sahin, B   +8 more
core   +1 more source

Myocarditis in β-Thalassemia Major

Circulation, 1995
Background Although acute pericarditis is a common complication of β-thalassemia major, the prevalence and consequences of myocarditis in this disease have not been investigated. Methods and Results A prospective 5-year follow-up study was carried out in all patients with β ...
KREMASTINOS, DT, TINIAKOS, G, THEODORAKIS, GN, KATRITSIS, DG, TOUTOUZAS, PK   +4 more
openaire   +3 more sources

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

ALPHA-THALASSEMIA AND BETA-THALASSEMIA IN A TURKISH FAMILY [PDF]

, 1977
A Turkish family is described in which 3 children have a clinical picture similar to that of thalassemia major, with typical red cell morphology and indices, and with about 10% Hb Bart''s but without measurable amounts of Hb H.
HUISMAN, THJ, YETGIN, SEVGİ, ALTAY, C, SAY, B   +3 more
core   +1 more source

Comparison of Right and Left Side Heart Functions in Patients with Thalassemia Major, Patients with Thalassemia Intermedia, and Control Group

Journal of Tehran University Heart Center, 2015
Background: Heart disease is the main cause of mortality and morbidity in patients with beta thalassemia, rendering its early diagnosis vital. We studied and compared echocardiographic findings in patients with beta thalassemia major, patients with beta ...
Noormohammad Noori, Mehdi Mohamadi, Kambiz Keshavarz, SeyedMostafa Alavi, Maziar Mahjoubifard, Yalda Mirmesdagh   +5 more
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Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source