Results 71 to 80 of about 1,157,565 (202)

Avascular necrosis of the femoral head among children and adolescents with sickle cell disease in Greece

Haematologica, 2002
Hemoglobinopathies are very common in Greece, the incidence of beta-thalassemia trait being 8% and that of sickle cell trait ranging from 1 to 32% in various districts.
M Athanassiou-Metaxa, J Kirkos, A Koussi, E Hatzipantelis, I Tsatra, M Economou   +5 more
doaj  

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, Volume 13, Issue 50, 7 September 2026.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

Detection of Hb variants and hemoglobinopathies in Indian population using HPLC: Report of 2600 cases

Indian Journal of Pathology and Microbiology, 2010
Background: Inherited abnormalities of hemoglobin synthesis include a myriad of disorders ranging from thalassemia syndromes to structurally abnormal hemoglobin variants. Identification of these disorders is immensely important epidemiologically and aid
Sachdev Ritesh, Dam Arpita, Tyagi Gaurav
doaj  

Genotype–phenotype correlation among beta-thalassemia and beta-thalassemia/HbE disease in Thai children: predictable clinical spectrum using genotypic analysis

, 2018
Chanchai Traivaree,1 Chalinee Monsereenusorn,1 Piya Rujkijyanont,1 Warakorn Prasertsin,2 Boonchai Boonyawat3 1Division of Hematology/Oncology, Department of Pediatrics, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand; 2Department of ...
Rujkijyanont P, Boonyawat B, Traivaree C, Monsereenusorn C, Prasertsin W   +4 more
core  

Inherited microcytic anemias due to disorders of iron and heme metabolism: An updated clinical review

HemaSphere, Volume 10, Issue 9, September 2026.
Abstract Microcytic anemia is among the most common hematological abnormalities in clinical practice and is usually attributable to iron deficiency, thalassemia traits, or anemia of inflammation. A small but clinically important subset of patients, however, has inherited disorders of iron metabolism or heme synthesis presenting with persistent ...
Alexandros Makis, Ioanna Saougou, Eleftheria Hatzimichael   +2 more
wiley   +1 more source

Spectrum of thalassemias and hemoglobinopathies in West Bengal: A study of 90,210 cases by cation exchange high-performance liquid chromatography method over a period of 8 years

Journal of Applied Hematology, 2014
Background: Thalassemias and hemoglobinopathies are highly prevalent in India. Identification of these disorders is important for epidemiologic purposes and for prevention of thalassemia major and clinically severe hemoglobinopathies. Objectives: The aim
Santosh Kumar Mondal, Senjuti Dasgupta, Saikat Mondal, Nikhilesh Das   +3 more
doaj   +1 more source

Academic Performance Among Children With Sickle Cell Disease in Low‐ and Middle‐Income Countries: A Systematic Review

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aim Children with sickle cell disease (SCD) in low‐ and middle‐income countries (LMICs) face significant disease‐related challenges and socioeconomic status (SES) disparities that may negatively impact their academic performance. This systematic review synthesized existing evidence on academic performance among children with SCD
Shubaya K. Naggayi, Paul Bangirana, Simple Ouma, Mary Nyakato, Alison A. Kinengyere, Dickens Akena, Nancy S. Green, Richard Idro   +7 more
wiley   +1 more source

Prevalence of Beta Thalassemia Trait in Denizli.

Turkish journal of haematology : official journal of Turkish Society of Haematology, 2016
Beta thalassemia, characterized by the deficiency or the absence of beta globulin production, is the most widespread inherited disorder in the world and is also common in Turkey. To determine the prevalence of carriers for beta thalassemia, we screened the couples before their marriage.
Z, Bolaman, Y, Enli, M, Köseoğlu, H, Koyuncu, D, Aslan   +4 more
openaire   +1 more source

Hb leeds [beta 56(D7)Gly -> Cys] : A new hemoglobin that aggravates anemia in a child with beta(0)-thalassemia trait

, 2007
A novel beta chain variant found in combination with beta-thalassemia (thal) was identified in a male infant by electrospray ionization mass spectrometry (ESTMS). Analysis of the infant's denatured blood and a 30 min.
Williams, Jonathan P., Scrivens, James H., Green, Brian N., Scrivens, James, Sutcliffe, Michaela, Farrar, Lisa M.   +5 more
core   +1 more source

Impact of Genetic Polymorphisms in Modifier Genes in Determining Fetal Hemoglobin Levels in Beta-Thalassemia

, 2023
Genetic polymorphisms in Quantitative Trait Loci (QTL) genes such as BCL11A, HBS1L-MYB and KLF1 have been reported to influence fetal hemoglobin (HbF) levels.
Kausik Mandal, Poonam Tripathi, Aditya Narayan Sarangi, Anshul Gupta, Sarita Agarwal   +4 more
core   +1 more source