Results 101 to 110 of about 46,357 (231)

A Dual Role of Complement Activation in the Development of Fulminant Hepatic Failure Induced by Murine-Beta-Coronavirus Infection

Frontiers in Cellular and Infection Microbiology, 2022
With the epidemic of betacoronavirus increasing frequently, it poses a great threat to human public health. Therefore, the research on the pathogenic mechanism of betacoronavirus is becoming greatly important. Murine hepatitis virus strain-3 (MHV-3) is a
Yingying Fang, Yingying Fang, Yan Guo, Tongtong Gao, Xuelian Han, Yuting Jiang, Min Li, Wei Xue, Binhui Yang, Yujun Cui, Yujun Cui, Shihui Sun, Guangyu Zhao, Guangyu Zhao   +13 more
doaj   +1 more source

Memory T Cell Responses Targeting the SARS Coronavirus Persist up to 11 Years Post-Infection [PDF]

, 2016
10.1016/j.vaccine.2016.02.063Vaccine34172008 ...
Bertoletti, Antonio, Chia, Adeline, Jadi, Ramesh S., Leong, Hoe Nam, Ng, Oi Wing, Tan, Anthony T, Tan, Yee Joo   +6 more
core   +1 more source

A 5-Lipoxygenase Inhibitor, Zileuton, Modulates Host Immune Responses and Improves Lung Function in a Model of Severe Acute Respiratory Syndrome (SARS) Induced by Betacoronavirus

Viruses, 2023
Exacerbated inflammatory responses are a hallmark of severe coronavirus disease 2019 (COVID-19). Zileuton (Zi) is a selective inhibitor of 5-lipoxygenase, an enzyme involved in the production of several inflammatory/pro-resolving lipid mediators. Herein,
R. D. Pereira, R. Rabelo, Natalia F. M. Oliveira, S. Porto, Ana Claudia Dos Santos Pereira Andrade, C. Queiroz-Junior, César Luís Nascimento Barbosa, Luiz Pedro de Souza-Costa, F. R. Santos, Fernando Bento Rodrigues Oliveira, Bárbara Luísa Vieira da Silva, Hanna L. Umezu, Raquel Ferreira, Glauber S F da Silva, J. S. Cruz, M. Teixeira, V. Costa, Fabiana Simão Machado   +17 more
semanticscholar   +1 more source

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Dietary Vitamin D Mitigates Coronavirus-Induced Lung Inflammation and Damage in Mice

Viruses, 2023
The COVID-19 pandemic caused by the SARS-CoV-2 (β-CoV) betacoronavirus has posed a significant threat to global health. Despite the availability of vaccines, the virus continues to spread, and there is a need for alternative strategies to alleviate its ...
Gabriel Campolina-Silva, Ana Cláudia dos Santos Pereira Andrade, Manoela Couto, Paloma G. Bittencourt-Silva, Celso M. Queiroz-Junior, Larisse de Souza B. Lacerda, Ian de Meira Chaves, Leonardo C. de Oliveira, Fernanda Martins Marim, Cleida A. Oliveira, Glauber S. F. da Silva, Mauro Martins Teixeira, Vivian Vasconcelos Costa   +12 more
doaj   +1 more source

Human Betacoronavirus 2c EMC/2012–related Viruses in Bats, Ghana and Europe [PDF]

Emerging Infectious Diseases, 2013
(Uploaded by Plazi for the Bat Literature Project) We screened fecal specimens of 4,758 bats from Ghana and 272 bats from 4 European countries for betacoronaviruses. Viruses related to the novel human betacoronavirus EMC/2012 were detected in 46 (24.9%) of 185 Nycteris bats and 40 (14.7%) of 272 Pipistrellus bats.
Augustina Annan, Heather Baldwin, Victor M. Corman, Stefan M. Klose, Michael Owusu, Evans Ewald Nkrumah, Ebenezer K. Badu, Priscilla Anti, Olivia Agbenyega, Benjamin Meyer, Samuel Oppong, Yaw Adu Sarkodie, Elisabeth K. V. Kalko, Peter H. C. Lina, Lena Godlevska, Chantal Reusken, Antje Seebens, Florian Gloza‐Rausch, Peter Vallo, Marco Tschapka, Christian Drosten, Jan Felix Drexler   +21 more
openaire   +5 more sources

Hallmarks of Alpha- and Betacoronavirus non-structural protein 7+8 complexes [PDF]

Science Advances, 2020
Coronaviral nsp7+8 complexes follow species- and stoichiometry-specific assembly pathways determined by few amino acid changes.
Krichel, Boris, Bylapudi, Ganesh, Schmidt, Christina, Blanchet, Clement, Schubert, Robin, Brings, Lea, Koehler, Martin, Zenobi, Renato, Svergun, Dmitri, Lorenzen, Kristina, Madhugiri, Ramakanth, Ziebuhr, John, Uetrecht, Charlotte   +12 more
openaire   +6 more sources

Five‐Year (2017–2022) Evolutionary Dynamics of Human Coronavirus OC43 in Southern France Based on Whole Genome Next‐Generation Sequencing

Journal of Medical Virology, Volume 97, Issue 12, December 2025.
ABSTRACT HCoV‐OC43 genomes and their evolution are scarcely studied worldwide and in France, with only 361 genomes available as of October 2023. Here, an in‐house PCR amplification system was implemented to obtain retrospectively by next‐generation sequencing, then analyze HCoV‐OC43 genomes for infections diagnosed with this virus in southern France ...
Hikmat Houmadi, Céline Boschi, Marine Lefebvre, Lorlane Le Targa, Justine Py, Jean‐Christophe Lagier, Lucile Lesage, Jacques Fantini, Aurélie Morand, Bernard La Scola, Philippe Colson   +10 more
wiley   +1 more source

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China. [PDF]

, 2020
An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses.
Cheng, Genhong, Ding, Xiao, Huang, Baoying, Jiang, Taijiao, Meng, Jing, Niu, Peihua, Peng, Yousong, Quan, Lijun, Sheng, Jie, Tan, Wenjie, Wang, Jiangyuan, Wang, Xianyue, Wu, Aiping, Xia, Zanxian, Zhang, Zheng, Zhu, Zhaozhong   +15 more
core  

Coronavirus HKU15 in respiratory tract of pigs and first discovery of coronavirus quasispecies in 5′-untranslated region [PDF]

, 2017
published_or_final_versio
Chow, WN, Fong, JYH, Lau, CY, Lau, SKP, Tsang, CC, Wong, PC, Woo, PCY, Yuen, KY   +7 more
core   +1 more source