Results 101 to 110 of about 44,666 (245)

Discovery of novel alphacoronaviruses in European rodents and shrews [PDF]

, 2016
Eight hundred and thirteen European rodents and shrews encompassing seven different species were screened for alphacoronaviruses using PCR detection.
Ball, J, Behnke, J, Chapman, S, Danjittrong, T, Dayman, E, Dobbs, P, Horncastle, E, McClure, C, Onianwa, O, Strong, V, Tarlinton, R, Tsoleridis, T, Wachtl, M, Zhu, M   +13 more
core   +2 more sources

Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure–Activity Relationship

Influenza and Other Respiratory Viruses, Volume 19, Issue 10, October 2025.
ABSTRACT Background Natural alkaloids are a structurally diverse class of bioactive compounds with significant therapeutic potential. This study aimed to evaluate the in vitro antiviral activity of various natural alkaloids against coronaviruses, clarify molecular effects via bioassays and docking, and explore structure–activity relationships.
Marcela Safratova, Yu‐Li Chen, Anna Hostalkova, Jakub Chlebek, Chung‐Fan Hsieh, Bing‐Hung Chen, Lucie Cahlikova, Stefan Kosturko, Anders Backlund, Jim‐Tong Horng, Tsong‐Long Hwang, Michal Korinek   +11 more
wiley   +1 more source

Transiciones entre los estados de diagnóstico de personas con la COVID-19 en Colombia

Revista Panamericana de Salud Pública, 2020
Objetivo. Determinar las probabilidades de transición entre distintos tipos de atención y estados para la población infectada con la COVID-19 en Colombia, por grupos de edad. Métodos.
Luis Carlos Manrique Ruiz, Guberney Muñetón Santa, Osmar Leandro Loaiza Quintero   +2 more
doaj   +1 more source

Detecting and Monitoring Porcine Hemagglutinating Encephalomyelitis Virus, an Underresearched Betacoronavirus

mSphere, 2020
There is a paucity of information concerning the ecology of porcine hemagglutinating encephalomyelitis virus (PHEV) in commercial swine herds. This study provided evidence that PHEV infection is endemic and highly prevalent in U.S. swine herds. These results raised questions for future studies regarding the impact of endemic PHEV on swine health and ...
Mora-Díaz, Juan Carlos, Magtoto, Ronaldo, Houston, Elizabeth, Baum, David, Carrillo-Ávila, José Antonio, Temeeyasen, Gun, Zimmerman, Jeff, Piñeyro, Pablo, Giménez-Lirola, Luis   +8 more
openaire   +5 more sources

Impact of COVID-19 on maxillofacial surgery practice: a worldwide survey [PDF]

, 2020
The outbreak of coronavirus disease 2019 (COVID-19) is rapidly changing our habits. To date, April 12, 2020, the virus has reached 209 nations, affecting 1.8 million people and causing more than 110,000 deaths. Maxillofacial surgery represents an example
Cascone, P, Fontanari, M, Maffia, F, Mercuri, L G, Vellone, V   +4 more
core   +1 more source

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, Volume 12, Issue 36, September 25, 2025.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source

Identification of the Receptor-Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1 [PDF]

Journal of Virology, 2015
ABSTRACT Coronavirus spike (S) glycoproteins mediate receptor binding, membrane fusion, and virus entry and determine host range. Murine betacoronavirus (β-CoV) in group A uses the N-terminal domain (NTD) of S protein to bind to its receptor, whereas the β-CoVs severe acute respiratory syndrome CoV in group B and Middle East respiratory ...
Zhaohui, Qian, Xiuyuan, Ou, Luiz Gustavo Bentim, Góes, Christina, Osborne, Anna, Castano, Kathryn V, Holmes, Samuel R, Dominguez   +6 more
openaire   +2 more sources

Avoiding Regions Symptomatic of Conformational and Functional Flexibility to Identify Antiviral Targets in Current and Future Coronaviruses [PDF]

, 2016
Within the last 15 years, two related coronaviruses (Severe Acute Respiratory Syndrome [SARS]-CoV and Middle East Respiratory Syndrome [MERS]-CoV) expanded their host range to include humans, with increased virulence in their new host. Coronaviruses were
Rahaman, Jordon, Siltberg-Liberles, Jessica   +1 more
core   +1 more source

Seasonal Coronavirus‐Induced Immunological Imprinting and Previous Herpesvirus Infections in Patients With Long COVID

Journal of Medical Virology, Volume 97, Issue 9, September 2025.
ABSTRACT Long COVID (LC) is a post‐acute infection syndrome affecting 5%–10% of individuals infected by SARS‐CoV‐2. Here, we aimed to study SARS‐CoV‐2 humoral immunity, immunological imprinting by endemic coronaviruses, and previous herpesvirus infections in LC. We included 47 LC patients and 41 controls who fully recovered from COVID‐19.
W. Ashwin Mak, Daphne Wapperom, Anne‐Lotte Redel, Johannes G. M. Koeleman, Pieter W. Smit, Wai‐Kwan Lam‐Tse, Tom van der Poll, Hung‐Jen Chen, Jeroen den Dunnen, Gert‐Jan Braunstahl, David S. Y. Ong   +10 more
wiley   +1 more source

Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3 [PDF]

, 2016
published_or_final_versio
Chan, CP, Fung, CL, Jin, D, Lui, PY, Siu, KL, WONG, LYR, Woo, PCY, Yeung, ML, Yuen, KS, Yuen, KY   +9 more
core   +5 more sources