Results 91 to 100 of about 41,690 (230)

Identification of the Fusion Peptide-Containing Region in Betacoronavirus Spike Glycoproteins [PDF]

Journal of Virology, 2016
ABSTRACT The fusion peptides (FP) play an essential role in fusion of viral envelope with cellular membranes. The location and properties of the FPs in the spike (S) glycoproteins of different coronaviruses (CoV) have not yet been determined. Through amino acid sequence analysis of S proteins of representative CoVs, we identified
Xiuyuan, Ou, Wangliang, Zheng, Yiwei, Shan, Zhixia, Mu, Samuel R, Dominguez, Kathryn V, Holmes, Zhaohui, Qian   +6 more
openaire   +2 more sources

Flies (Insecta, Diptera) collected in the environment of dairy farms as carriers of rotavirus A and betacoronavirus.

Journal of Applied Microbiology, 2023
AIMS We aimed to investigate the prevalence of rotavirus and coronavirus in dipterans that commonly inhabit the environment of dairy farms. METHODS AND RESULTS We collected 217 insect specimens from nine dairy farms, which were examined through hemi ...
A. Bertolini, P. Thyssen, P. Brandão, A. M. Prado, S. O. de Souza Silva, Mateus de Souza Ribeiro Mioni, Fábio Lucas Rezende de Gouvea, José Carlos de Figueiredo Pantoja, H. Langoni, F. F. Guimarães, S. Joaquim, S. Guerra, D. da Silva Leite, V. M. Rall, R. T. Hernandes, S. B. Lucheis, G. A. M. Rossi, M. Ribeiro   +17 more
semanticscholar   +1 more source

Characterization and immunogenicity of nanoparticle vaccines displaying embecovirus spike proteins

Biotechnology Progress, Volume 42, Issue 5, September/October 2026.
Virus‐like particle vaccines displaying spike proteins from OC43, HKU1 A, and HKU1 B were evaluated in mice for their ability to elicit antibodies against the spike proteins from OC43, HKU1 A, HKU1 B, and HKU1 C. Abstract Endemic human coronaviruses OC43 and HKU1 cause widespread respiratory infections and can be associated with severe illness in ...
Peter J. Halfmann, Augustine Duffy, Alex Wee, Noah Anderson, Jackson Terrell, Yoshihiro Kawaoka, Ravi S. Kane   +6 more
wiley   +1 more source

Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication [PDF]

, 2021
International audienceAs coronaviruses (CoVs) replicate in the host cell cytoplasm, they rely on their own capping machinery to ensure the efficient translation of their mRNAs, protect them from degradation by cellular 5- exoribonucleases, and escape ...
Canard, B., Snijder, E.J., Ogando, Natacha, S, El Kazzi, Priscila, Snijder, Eric J, Ogando, Natacha S, Posthuma, Clara C, Snijder, Eric, J, Posthuma, C.C., Zevenhoven-Dobbe, Jessika C, Zevenhoven-Dobbe, J.C., Zevenhoven-Dobbe, Jessika, C, Bontes, Brenda, W, Ogando, N.S., Canard, Bruno, Thiel, Volker, Decombe, Alice, Posthuma, Clara, C S, Thiel, V., Bontes, Brenda W, Kazzi, P. el, Ferron, F., Bontes, B.W., Decroly, E., Decroly, Etienne, Decombe, A., Kazzi, Priscila El, Ogando, Natacha,, Bontes, Brenda,, Posthuma, Clara, C, Snijder, Eric,, Posthuma, Clara,, Zevenhoven-Dobbe, Jessika,, Ferron, François, Clara C. Posthuma, Natacha S. Ogando, Volker Thiel, Bruno Canard, Jessika C. Zevenhoven-Dobbe, Brenda W. Bontes, Priscila El Kazzi, François Ferron, Alice Decombe, Eric J. Snijder, Etienne Decroly   +44 more
core   +2 more sources

PHEV infection: A promising model of betacoronavirus-associated neurological and olfactory dysfunction

PLoS Pathogens, 2022
Porcine hemagglutinating encephalomyelitis virus (PHEV) is a highly neurotropic coronavirus belonging to the genus Betacoronavirus. Similar to pathogenic coronaviruses to which humans are susceptible, such as SARS-CoV-2, PHEV is transmitted primarily ...
Jun-Chao Shi, Zi Li, Jing Zhang, Rongyi Xu, Y. Lan, Jiyu Guan, Rui Gao, Zhenzhen Wang, Hui-Jun Lu, Baofeng Xu, Kui Zhao, F. Gao, Wen-Qi He   +12 more
semanticscholar   +1 more source

Haematological and Biochemical Parameters of COVID‐19 Patients Hospitalised at Selected Central Hospitals in Malawi: A Retrospective Study

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims COVID‐19 is an infectious respiratory disease caused by SARS‐CoV‐2. It was first reported in China in 2019 and spread rapidly to the rest of the world, leading to alarming morbidity and mortality. Haematological and biochemical parameters have been used in routine practice as prognostic markers of disease severity. However,
Ackim Munthali, Ethel M'kandawire, Nozyechi Ngulube Chidumayo   +2 more
wiley   +1 more source

Conserved structures and dynamics in 5′-proximal regions of Betacoronavirus RNA genomes

Nucleic Acids Research
Betacoronaviruses are a genus within the Coronaviridae family of RNA viruses. They are capable of infecting vertebrates and causing epidemics as well as global pandemics in humans.
T. R. de Moura, E. Purta, A. Bernat, Eva M. Martín-Cuevas, M. Kurkowska, E. Baulin, Sunandan Mukherjee, Jakub Nowak, A. Biela, M. Rawski, S. Glatt, F. Moreno-Herrero, J. M. Bujnicki   +12 more
semanticscholar   +1 more source

Design of a pan-betacoronavirus vaccine candidate through a phylogenetically informed approach

Science Advances, 2023
Coronaviruses are a diverse family of viruses that crossed over into humans at least seven times, precipitating mild to catastrophic outcomes. The severe acute respiratory syndrome coronavirus 2 pandemic renewed efforts to identify strains with zoonotic ...
Eric Lewitus, Hong-Jun Bai, M. Rolland
semanticscholar   +1 more source

Investigation of PDCD1 Gene Polymorphisms and Haplotypes in COVID‐19 Severity and Outcome in a Brazilian Population

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT COVID‐19 severity and survival are influenced by the host immune response to SARS‐CoV‐2. Programmed cell death 1 (PD‐1), a key immune checkpoint, regulates T‐cell activation and antiviral immune balance. Since genetic variability can modulate these responses, we investigated whether the PDCD1 polymorphisms rs11568821 C > T, rs2227982 G > A ...
Sarah Lott Moretto, Pedro Luis Candido de Souza Cassela, Guilherme Lerner Trigo, Marcell Alysson Batisti Lozovoy, Zuleica Naomi Tano, Andrea Name Colado Simão, Karen Brajão de Oliveira   +6 more
wiley   +1 more source

Human Betacoronavirus OC43 Interferes with the Integrated Stress Response Pathway in Infected Cells

Viruses
Viruses evolve many strategies to ensure the efficient synthesis of their proteins. One such strategy is the inhibition of the integrated stress response—the mechanism through which infected cells arrest translation through the phosphorylation of the ...
Stacia M. Dolliver, Caleb Galbraith, Denys A. Khaperskyy   +2 more
semanticscholar   +1 more source