Results 71 to 80 of about 41,690 (230)

TNF/iNOS/NO pathway mediates host susceptibility to endothelial-dependent circulatory failure and death induced by betacoronavirus infection.

Clinical science, 2023
Poor disease outcomes and lethality are directly related to endothelial dysfunction in betacoronavirus infections. Here, we investigated the mechanisms underlying the vascular dysfunction caused by the betacoronaviruses MHV-3 and SARS-CoV-2.
Ildernandes Vieira-Alves, A. P. Alves, N. Souza, Tales Leonardo de Melo, Leda Maria de Castro Coimbra Campos, Larisse de Souza Barbosa Lacerda, C. Queiroz-Junior, A. C. Dos Santos Pereira Andrade, L. Barcelos, M. Teixeira, V. Costa, S. Cortes, V. Lemos   +12 more
semanticscholar   +1 more source

Coverage plot of betacoronavirus reads to coronavirus OC43 reference genome AY391777.1 (depth of coverage: 428).

, 2019
Coverage plot of betacoronavirus reads to coronavirus OC43 reference genome AY391777.1 (depth of coverage: 428).
Marianne Aanerud (318457), Aloys C. M. Kroes (7542383), Ellen C. Carbo (7542371), Igor Sidorov (7329359), Tomas M. Eagan (7392587), Pieter S. Hiemstra (7392584), Anneloes L. van Rijn (7542368), Nikos Pappas (7542374), Mariet Feltkamp (7542377), Eric C. J. Claas (7542380), Sander van Boheemen (187826), Hailiang Mei (3404261), Per Bakke (164964), Jutte J. C. de Vries (7542386)   +13 more
core   +1 more source

COVID-19 y la pandemia global causada por un nuevo coronavirus

Universidad y Salud, 2020
Introducción: COVID-19 es una enfermedad respiratoria inédita que se reportó inicialmente como una neumonía atípica en diciembre de 2019. SARS-CoV-2, agente etiológico de esta patología, probablemente originado a partir de un virus de murciélago.
Mario Fernando Benavides-Rosero
doaj   +1 more source

A Dual Role of Complement Activation in the Development of Fulminant Hepatic Failure Induced by Murine-Beta-Coronavirus Infection

Frontiers in Cellular and Infection Microbiology, 2022
With the epidemic of betacoronavirus increasing frequently, it poses a great threat to human public health. Therefore, the research on the pathogenic mechanism of betacoronavirus is becoming greatly important. Murine hepatitis virus strain-3 (MHV-3) is a
Yingying Fang, Yingying Fang, Yan Guo, Tongtong Gao, Xuelian Han, Yuting Jiang, Min Li, Wei Xue, Binhui Yang, Yujun Cui, Yujun Cui, Shihui Sun, Guangyu Zhao, Guangyu Zhao   +13 more
doaj   +1 more source

Dietary Vitamin D Mitigates Coronavirus-Induced Lung Inflammation and Damage in Mice

Viruses, 2023
The COVID-19 pandemic caused by the SARS-CoV-2 (β-CoV) betacoronavirus has posed a significant threat to global health. Despite the availability of vaccines, the virus continues to spread, and there is a need for alternative strategies to alleviate its ...
Gabriel Campolina-Silva, Ana Cláudia dos Santos Pereira Andrade, Manoela Couto, Paloma G. Bittencourt-Silva, Celso M. Queiroz-Junior, Larisse de Souza B. Lacerda, Ian de Meira Chaves, Leonardo C. de Oliveira, Fernanda Martins Marim, Cleida A. Oliveira, Glauber S. F. da Silva, Mauro Martins Teixeira, Vivian Vasconcelos Costa   +12 more
doaj   +1 more source

The role of lysosomes as intermediates in betacoronavirus PHEV egress from nerve cells

Journal of Virology, 2023
The traditional view that betacoronaviruses exit occurs via the constitutive secretory route has recently been questioned by studies suggesting that this process involves lysosomal exocytosis.
Zhenzhen Wang, Wen-Qi He, Caili Li, Yuzhu Chen, Zi Li, Yubo Jiao, Jing Zhang, Jun-Chao Shi, Gaili Wang, Jiyu Guan, Kui Zhao, Deguang Song, Feng Gao, Y. Lan   +13 more
semanticscholar   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Identification of bovine coronavirus in a Daurian ground squirrel expands the host range of Betacoronavirus 1

Virologica Sinica, 2023
Highlights • BCoV DTA28 was identified in a Daurian ground squirrel (Spermophilus dauricus) in China.• BCoV DTA28 might have emerged through a spillover event from cattle to the rodent.• This is the first report of BCoV in rodents, highlighting the ...
Lin Xu, Wei Liu, Mengyu Bie, Tao Hu, D. Yan, Zhi-Shu Xiao, E. Holmes, Wei-Feng Shi   +7 more
semanticscholar   +1 more source

Characterization of Immune Responses to RBD‐SD1 Nanoparticle Vaccines Derived From ACE2‐Capable HKU5‐CoV‐2, NeoCoV, and HKU5 Merbecoviruses

Biotechnology and Bioengineering, EarlyView.
SpyCatcher‐mi3 nanoparticles presenting HKU5, NeoCoV, and HKU5‐CoV‐2 RBD‐SD1 induced strong, cross‐reactive IgG responses in immunized mice. The surrogate virus neutralization test demonstrated strong activity in sera from homologous vaccination. ABSTRACT Recent discoveries of merbecoviruses such as HKU5, NeoCoV, and HKU5‐CoV‐2 that use angiotensin ...
Peter J. Halfmann, Jeong Soo Lee, Augustine Duffy, Tong Wang, Bingcheng Huang, James Z. Kurdi, Ajay Inampudi, Natasha Chen, Elizabeth Frimpong, Carmen Rai, Yoshihiro Kawaoka, Ravi S. Kane   +11 more
wiley   +1 more source

Recombination and Positive Selection Differentially Shaped the Diversity of Betacoronavirus Subgenera

, 2020
The Betacoronavirus genus of mammal-infecting viruses includes three subgenera (Sarbecovirus, Embecovirus, and Merbecovirus), in which most known human coronaviruses, including SARS-CoV-2, cluster.
Manuela Sironi, Diego Forni, Rachele Cagliani   +2 more
core   +1 more source