Results 111 to 120 of about 41,690 (230)

Pre-pandemic artificial MERS analog of polyfunctional SARS-CoV-2 S1/S2 furin cleavage site domain is unique among spike proteins of genus Betacoronavirus

BMC Genomic Data
SARS-CoV-2 spike (S) glycoprotein furin cleavage site is a key determinant of SARS-CoV-2 virulence and COVID-19 pathogencity. Located at the S1/S2 junction, it is unique among sarbecoviruses but frequently found among betacoronaviruses.
A. M. Lisewski
semanticscholar   +1 more source

Targeting Middle East Respiratory Syndrome Coronavirus Spike Fusion Machinery With Antiviral Peptides: In Silico Exploration of the Heptad Repeat 2 Domain

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Griffithsin, Brevinin‐2, and CCL20 were identified as potent MERS‐CoV fusion inhibitor candidates targeting the HR2 domain through integrated molecular docking, MD simulations, and MM/PBSA analyses. These peptides demonstrated superior binding stability and favorable safety profiles compared to the standard inhibitor, supporting their potential as ...
Nasser Alotaiq, Doni Dermawan, Samir Chtita   +2 more
wiley   +1 more source

Identification of a Novel Betacoronavirus (Merbecovirus) in Amur Hedgehogs from China [PDF]

Viruses, 2019
While dromedaries are the immediate animal source of Middle East Respiratory Syndrome (MERS) epidemic, viruses related to MERS coronavirus (MERS-CoV) have also been found in bats as well as hedgehogs. To elucidate the evolution of MERS-CoV-related viruses and their interspecies transmission pathway, samples were collected from different mammals in ...
Susanna K. P. Lau, Hayes K. H. Luk, Antonio C. P. Wong, Rachel Y. Y. Fan, Carol S. F. Lam, Kenneth S. M. Li, Syed Shakeel Ahmed, Franklin W.N. Chow, Jian-Piao Cai, Xun Zhu, Jasper F. W. Chan, Terrence C. K. Lau, Kaiyuan Cao, Mengfeng Li, Patrick C. Y. Woo, Kwok-Yung Yuen   +15 more
openaire   +3 more sources

Human Coronavirus 229E Uses ORF4/4a to Antagonize the Host Restriction Factor SERINC5

MedComm, Volume 7, Issue 6, June 2026.
The seasonal human coronaviruses 229E and OC43 are common causes of mild respiratory infections but can cause severe disease in vulnerable individuals. Serine incorporator 5 (SERINC5) efficiently inhibits OC43, while hCoV‐229E uses its ORF4/4a accessory proteins to efficiently counteract this restriction by promoting relocalization of SERINC5 to ...
Qinya Xie, Sabrina Noettger, Jan Lawrenz, Sophie Stopper, Susanne Klute, Jan Münch, Dorota Kmiec, Qingxing Wang, Konstantin M. J. Sparrer, Frank Kirchhoff   +9 more
wiley   +1 more source

Isolation and characterization of a novel Betacoronavirus subgroup a coronavirus, rabbit coronavirus HKU14, from domestic rabbits

, 2012
We describe the isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14 (RbCoV HKU14), from domestic rabbits. The virus was detected in 11 (8.1%) of 136 rabbit fecal samples by reverse transcriptase PCR (
Woo, PCY, Tsang, AKL, Che, XY, Huang, Y, Lai, KKY, Yip, CCY, Fan, RYY, Guo, R, Wang, M, Yuen, KY, Lam, CSF, Lau, SKP, Chan, KH, Zheng, BJ   +13 more
core   +1 more source

RBD‐SD1 Nanoparticle Vaccines From DPP4‐Using Merbecoviruses Elicit a Cross‐Reactive Antibody Response but Limited Cross‐Protective Immunity

Biotechnology and Bioengineering, Volume 123, Issue 5, Page 1338-1349, May 2026.
SpyCatcher‐mi3 nanoparticles displaying RBD‐SD1 from MERS‐CoV, NL140422, and HKU4 elicited robust and cross‐reactive IgG responses in mice. Only MERS‐CoV RBD‐SD1 induced neutralizing antibodies against MERS‐CoV and protected human DPP4 mice from a MERS‐CoV challenge, indicating conserved serologic but limited cross‐neutralizing epitopes.
Peter J. Halfmann, Jeong Soo Lee, Tong Wang, Augustine Duffy, Janie E. Rogers, Natasha Chen, Elizabeth Frimpong, Carmen Rai, Yoshihiro Kawaoka, Ravi S. Kane   +9 more
wiley   +1 more source

Cytokine Expression During the Early Response of A549 Cells to Infection with Influenza Virus, Alphacoronavirus and Betacoronavirus

American Journal of Biochemistry and Biotechnology
: The escalating incidence of coronavirus infections underscores the critical need for a comprehensive understanding of the differential impacts of Human Coronaviruses (HCoVs) belonging to the Alphacoronavirus and Betacoronavirus genera.
Qian-Wen Wang, Jae Kyung Kim
semanticscholar   +1 more source

Betacoronavirus genomes: How genomic information has been used to deal with past outbreaks and the COVID-19 pandemic [PDF]

, 2020
In the 21st century, three highly pathogenic betacoronaviruses have emerged, with an alarming rate of human morbidity and case fatality. Genomic information has been widely used to understand the pathogenesis, animal origin and mode of transmission of ...
Rajeev, Sreekumari, Carlos M. Restrepo, Kennedy, Melissa A., Alejandro Llanes, Sreekumari Rajeev, Caballero, Zuleima, Llanes, Alejandro, Lleonart, Ricardo, Melissa A. Kennedy, Restrepo, Carlos M., Ricardo Lleonart, Zuleima Caballero   +11 more
core   +1 more source

Hibecovirus (genus Betacoronavirus) infection linked to gut microbial dysbiosis in bats

ISME Communications
Little is known about how zoonotic virus infections manifest in wildlife reservoirs. However, a common health consequence of enteric virus infections is gastrointestinal diseases following a shift in gut microbial composition.
D. W. Melville, Magdalena Meyer, A. Risely, K. Wilhelm, Heather J. Baldwin, Ebenezer K. Badu, E. E. Nkrumah, S. Oppong, N. Schwensow, M. Tschapka, P. Vallo, V. Corman, C. Drosten, Simone Sommer   +13 more
semanticscholar   +1 more source

Coronavirus Detection in Bats Captured on the Deforestation Arc of Mato Grosso, Brazil

Zoonoses and Public Health, Volume 73, Issue 3, Page 281-287, May 2026.
ABSTRACT Coronaviruses (CoV) are RNA viruses associated with enteric and respiratory diseases and known for their emergence potential in humans and other mammals. CoVs originate from zoonotic transmission, in which bats are natural reservoirs. Previous studies suggest that CoV diversity is positively correlated with bat diversity, whereas anthropogenic
Matheus Augusto Calvano Cosentino, Victor Wanderkoke, Francimeire Fernandes Ferreira, Sergio Gomes Silva, Mirela D'arc, André Felipe Andrade dos Santos   +5 more
wiley   +1 more source