Results 131 to 140 of about 41,690 (230)

Betacoronavirus internal protein: role in immune evasion and viral pathogenesis

Journal of Virology
ABSTRACT Betacoronaviruses express a small internal (I) protein that is encoded by the same subgenomic RNA (sgRNA) as the nucleocapsid (N) protein. Translation of the +1 reading frame of the N sgRNA through leaky ribosomal scanning leads to expression of the I protein.
Chaminda D. Gunawardene, Lok-Yin Roy Wong   +1 more
openaire   +2 more sources

Development of ACE2-tropic-betacoronavirus therapeutics for future pandemic preparedness

Nature Communications
A major challenge during viral pandemics is the ability to develop therapeutics whose efficacy can withstand viral genetic evolution. During the COVID-19 pandemic, five SARS-CoV-2 monoclonal antibody (mAb) therapeutics were rendered ineffective within a period of 2 years, leading to the U.S. FDA revoking their emergency use authorization.
Ashley Utz, Matt Armbrust, Thuy-Tien T. Nguyen, Mary Kate Morris, Chris O. Matthews, Pallavi Kompella, Zheng Cao, Ji Won Ha, Arvie Violette, R. Camille Brewer, Tobias V. Lanz, William H. Robinson, Duo Xu, Carl Hanson, Adrian Hugenmatter, Peter S. Kim   +15 more
openaire   +2 more sources

SARS-Coronavirus ancestor’s foot-prints in South-East Asian bat colonies and the refuge theory

, 2011
International audienceOne of the great challenges in the ecology of infectious diseases is to understand what drives the emergence of new pathogens including the relationship between viruses and their hosts.
Teeling, Emma, Gouilh, Meriadeg Ar, Emma Teeling, Puechmaille, Sébastien, Jean-Claude Manuguerra, Meriadeg Ar Gouilh, Gonzalez, Jean-Paul, Kittayapong, Pattamaporn, Jean-Paul Gonzalez, Pattamaporn Kittayapong, Manuguerra, Jean-Claude, Sébastien J. Puechmaille   +11 more
core   +1 more source

Genomic characterization and cross-species transmission potential of hedgehog coronavirus

One Health
In the 21st century, three betacoronaviruses (SARS-CoV, MERS-CoV and SARS-CoV-2) have emerged in humans worldwide as a result of animal spillover, causing severe respiratory infections and resulting in more than seven million deaths.
Andreia V.S. Cruz, Sérgio Santos-Silva, Luís Queirós-Reis, Clarisse Rodrigues, Vanessa Soeiro, Rachael E. Tarlinton, João R. Mesquita   +6 more
doaj   +1 more source

Betacoronavirus [PDF]

, 2020
openaire   +1 more source

Five-year longitudinal surveillance reveals the continual circulation of both alpha- and beta-coronaviruses in Plateau and Gansu pikas (Ochotona spp.) at Qinghai Lake, China1

Emerging Microbes and Infections
The discovery of alphacoronaviruses and betacoronaviruses in plateau pikas (Ochotona curzoniae) expanded the host range of mammalian coronavirus (CoV) to a new order – Lagomorpha.
Lin Xu, Meiqing Song, Xianzhi Tian, Ju Sun, Yanjun Wang, Mengyu Bie, Yuhai Bi, Edward C. Holmes, Yi Guan, Jianjun Chen, Juan Li, Weifeng Shi   +11 more
doaj   +1 more source

Convergent evolution of the G3BP1-binding motif in betacoronavirus nucleocapsid proteins

Virus Evolution
Abstract Betacoronaviruses (β-CoVs) display divergent mechanisms to evade host antiviral responses, yet the evolutionary origin and functional relevance of their strategies remain unclear. Stress granules (SGs), central to host defenses, are disrupted by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N ...
Cinzia Borgogna, Ilaria Cislaghi, Sarah Turati, Alessandra Mozzi, Diego Forni, Rachele Cagliani, Manuela Sironi, Marisa Gariglio   +7 more
openaire   +2 more sources

Advancements in the development of antivirals against SARS-Coronavirus

Frontiers in Cellular and Infection Microbiology
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) caused an outbreak in 2002-2003, spreading to 29 countries with a mortality rate of about 10%. Strict quarantine and infection control methods quickly stopped the spread of the disease.
Mrityunjay Kumar, Mirza Sarwar Baig, Kanchan Bhardwaj, Kanchan Bhardwaj   +3 more
doaj   +1 more source

Detection of avian, murine, bovine, shrew, and bat coronaviruses in wild mammals from Mexico

Virology Journal
Coronaviruses infect a wide range of animal and human hosts. Some human coronaviruses, such as SARS-CoV, MERS-CoV, and SARS-CoV-2, originated in animals, with bats often serving as ancestral hosts.
Jocelyn Medina-Gudiño, Yolanda López-Vidal, J. Adolfo Pardo-Tovar, Lauro Velázquez-Salinas, Francisco Javier Basurto-Alcántara   +4 more
doaj   +1 more source

Evolution-Informed Viroinformatics Identifies Conserved Immune Targets with Predicted Lower Mutational Vulnerability Across Betacoronaviruses. [PDF]

Viruses
Alshammari J, Alqahtani HA, Alonaizan R, Rahman IU, Alzhrani K, Al-Hoshani N, Alwaili MA, Aziz T.   +7 more
europepmc   +1 more source