Results 111 to 120 of about 46,357 (231)

Selective phosphodiesterase 4 inhibitor roflumilast reduces inflammation and lung injury in models of betacoronavirus infection in mice

Inflammation Research
We aimed to understand the potential therapeutic and anti-inflammatory effects of the phosphodiesterase-4 (PDE4) inhibitor roflumilast in models of pulmonary infection caused by betacoronaviruses.
V. A. Beltrami, Flávia Rayssa Braga Martins, Débora Gonzaga Martins, C. Queiroz-Junior, F. B. Felix, Letícia Cassiano Resende, F. R. Santos, Larisse S B Lacerda, Victor R M Costa, Walison Nunes da Silva, Pedro Pires Goulart Guimarães, Goulart Guimaraes, F. Soriani, M. M. Teixeira, V. V. Costa, Vanessa R Pinho   +15 more
semanticscholar   +1 more source

Cu and Cu‐30Ni Alloy as Anti‐Viral Materials for High‐Touch Surfaces: Efficacy in a Simulated Public Environment with Frequent Cleaning Practices

Advanced Materials Interfaces, Volume 12, Issue 22, November 22, 2025.
This study evaluates the antiviral efficacy and corrosion behavior of pure copper and Cu‐30Ni alloy on high‐touch surfaces under simulated public conditions with periodic cleaning. Copper shows faster virus inactivation due to higher ion release, while Cu‐30Ni offers better aesthetic durability.
Valentin Romanovski, Elena Romanovskaia, Victor Wallemacq, Carol F. Glover, John Emery, Tsuyoshi Miyake, Wuhuan Zhang, Timothy D. Montoya, Stephen J. McDonnell, Daniel A. Engel, John R. Scully   +10 more
wiley   +1 more source

Design of a pan-betacoronavirus vaccine candidate through a phylogenetically informed approach

Science Advances, 2023
Coronaviruses are a diverse family of viruses that crossed over into humans at least seven times, precipitating mild to catastrophic outcomes. The severe acute respiratory syndrome coronavirus 2 pandemic renewed efforts to identify strains with zoonotic ...
E. Lewitus, Hongjun Bai, M. Rolland
semanticscholar   +1 more source

Evaluation of nine serological rapid tests for the detection of SARS-CoV-2

Revista Panamericana de Salud Pública, 2020
Objective. To evaluate the operative capacity of nine serological rapid tests to detect the IgM/IgG antibodies response in serum from patients with SARS-CoV-2 in different clinical stages. Methods.
Marcela Mercado, Jeadran Malagón-Rojas, Gabriela Delgado, Vivian Vanesa Rubio, Lida Muñoz Galindo, Eliana L. Parra Barrera, Paula Gaviria, Gabriela Zabaleta, Zonia Alarcon, Adriana Arévalo, Helly Casallas Cifuentes, Kelly Estrada, Gloria Puerto, María T. Herrera Sepúlveda, Helena Rodríguez, Marisol Galindo, Martha Lucía Ospina Ramírez   +16 more
doaj   +1 more source

Avoiding Regions Symptomatic of Conformational and Functional Flexibility to Identify Antiviral Targets in Current and Future Coronaviruses [PDF]

, 2016
Within the last 15 years, two related coronaviruses (Severe Acute Respiratory Syndrome [SARS]-CoV and Middle East Respiratory Syndrome [MERS]-CoV) expanded their host range to include humans, with increased virulence in their new host. Coronaviruses were
Rahaman, Jordon, Siltberg-Liberles, Jessica   +1 more
core   +1 more source

Structural insights into SARS‐CoV‐2 nonstructural protein 4 (nsp4) biogenesis

Protein Science, Volume 34, Issue 11, November 2025.
Abstract The SARS‐CoV‐2 virus—responsible for the COVID‐19 pandemic—requires a replication–transcription complex (RTC) for efficient RNA synthesis and viral propagation. One critical RTC component is nonstructural protein 4 (nsp4), a multipass transmembrane (TM) protein implicated in endoplasmic reticulum (ER) membrane rearrangements and double ...
José M. Acosta‐Cáceres, Fabio Lolicato, Laura Gadea‐Salom, Juan Ortiz‐Mateu, Diego Belda, Luis Martínez‐Gil, María Jesús García‐Murria, Ismael Mingarro   +7 more
wiley   +1 more source

A Narrative Review on the Recent Insights Into the Pathogenicity and Potential Role of Middle East Respiratory Syndrome Coronavirus (MERS‐CoV) in the Emergence of “Disease X”

Health Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background and Aims Following the end of the COVID‐19 global emergency, concern has shifted to “Disease X,” a hypothetical, highly transmissible, and deadly pathogen, and Middle East Respiratory Syndrome Coronavirus (MERS‐CoV) is a prime candidate for this. This review explores its epidemiology, mutations, transmission, and potential to become
Zubaier Ahmed, Kazi Milenur Rahman Prattay, Sabrina Sharmin, Fatema‐Tuz‐Zohora, Asef Raj, Forhad Bin Faruk, Bagdad Ahmed, Humair Bin Md Omer, Anika Awal Omi, Fazle Rabbi, Nasiba Binte Bahar, Sumiya Sharmin Mou, Mehedi Islam, Eshaba Karim, Md. Elias Al‐Mamun   +14 more
wiley   +1 more source

Specific serology for emerging human coronaviruses by protein microarray [PDF]

, 2013
We present a serological assay for the specific detection of IgM and IgG antibodies against the emerging human coronavirus hCoV-EMC and the SARS-CoV based on protein microarray technology.
Bedrijfsvoering, Bosch, B J, de Sousa, R, Dep Infectieziekten Immunologie, Dittmer, U, Drosten, C, Godeke, G J, Haagmans, B, Koopmans, M, LS Virologie, Meyer, B, Mou, H, Müller, M A, Osterhaus, A, Reusken, C, Rottier, P, Schuurman, Nancy, van der Hoek, L   +17 more
core   +3 more sources

2019 Novel Coronavirus (COVID-19) Pandemic: Built Environment Considerations To Reduce Transmission. [PDF]

, 2020
With the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in coronavirus disease 2019 (COVID-19), corporate entities, federal, state, county, and city governments, universities, school districts, places of worship,
Coil, David A, Dietz, Leslie, Eisen, Jonathan A, Fretz, Mark, Horve, Patrick F, Van Den Wymelenberg, Kevin   +5 more
core   +2 more sources

[Genetic diversity of Siberian bovine coronavirus isolates (Coronaviridae: Coronavirinae: Betacoronavirus-1: Bovine-Like coronaviruses)].

Voprosy virusologii, 2023
INTRODUCTION Bovine coronaviruses (BCoVs) are causative agents of diarrhea, respiratory diseases in calves and winter cow dysentery. The study of genetic diversity of these viruses is topical issue.
A. Glotov, A. V. Nefedchenko, A. Yuzhakov, S. Koteneva, T. Glotova, A. Komina, N. Krasnikov   +6 more
semanticscholar   +1 more source