Results 111 to 120 of about 38,196 (216)

Coronavirus Disease (COVID-19) Outbreak and Adaptive Immune System of the Body: A Review [PDF]

Journal of Clinical and Diagnostic Research, 2020
In December 2019, a severe disease with an unknown aetiology has appeared in a Wuhan City, Hubei province, China. Immediately, it was identified as novel Coronavirus Disease (COVID-19) that has spread globally and also called Severe Acute Respiratory ...
Amar Deep, SUCHIT SWAROOP, Ajay Kumar, Sumit Rungta   +3 more
doaj   +1 more source

Organic Transistor‐Based Biosensors for Viral RNA Detection and Variant Monitoring: From SARS‐CoV‐2 to Effective Management of Future Pandemics

Advanced Sensor Research, Volume 4, Issue 6, June 2025.
A novel approach for direct sensing of viral RNA is proposed, allowing PCR‐free detection of viral RNA from genomic material, and variants screening by discrimination of polymorphic amplicons. The device is a cost‐effective, user‐friendly platform suitable for both mass screening kits and as a laboratory tool for an optimized management of resources ...
Stefano Lai, Roberto Cusano, Alessandra Scano, Giorgio Fotia, Annalisa Bonfiglio   +4 more
wiley   +1 more source

Betacoronavirus 1 in alpacas (Vicugna pacos) in the High Peruvian Andes

Small Ruminant Research, 2015
Genetic sequences highly related to Bovine coronavirus (BCoV) were detected in fecal samples from Peruvian 1-3 week old alpaca crias located on six farms in Puno department, some of which shared pastures with cattle. A total of 60 samples were screened for coronavirus using a nested PCR amplification of a fragment of the RNA-dependent RNA polymerase ...
L. Luna, Lenin Maturrano, Raúl Rosadio, Fernanda Dornelas Florentino Silva, Fábio Gregori, Paulo Eduardo Brandão, Rodrigo Martins Soares   +6 more
openaire   +3 more sources

Phylogenetic analysis of the betacoronavirus S1 subunit [PDF]

F1000Research, 2020
The ongoing pandemic outbreak of coronavirus disease 2019 (COVID-19) has been caused by the new betacoronavirus (BetaCoV) severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Together with other epidemic outbreaks of BetaCoV infectious diseases (Severe Acute Respiratory Syndrome (SARS) in 2002-2003 in China and Middle East Respiratory ...
openaire   +2 more sources

Evaluation of Betacoronavirus OC43 and SARS-CoV-2 Elimination by Zefero Air Sanitizer Device in a Novel Laboratory Recirculation System

Pathogens, 2022
Indoor air sanitizers contrast airborne diseases and particularly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/Coronavirus disease 2019 (COVID-19).
M. Nicolò, M. Rizzo, Nicole Palermo, C. Gugliandolo, S. Cuzzocrea, S. Guglielmino   +5 more
semanticscholar   +1 more source

Identification of potential SARS‐CoV‐2 genomic regions representing hallmarks for adaptation to different hosts

iMetaOmics, Volume 2, Issue 2, June 2025.
The k‐mer‐based pipeline, namely the Pathogen Origin Recognition Tool using Enriched K‐mers (PORT‐EK) identifies genomic regions enriched in the respective hosts after the comparison of multi‐genomes of isolates between different host species. The enriched k‐mer counts, which may serve as a potential marker, enable the classification and prediction of ...
Janusz Wiśniewski, Heng‐Chang Chen
wiley   +1 more source

Optimization of Structure‐Guided Development of Chemical Probes for the Pseudoknot RNA of the Frameshift Element in SARS‐CoV‐2

Angewandte Chemie, Volume 137, Issue 9, February 24, 2025.
The SARS‐CoV‐2 frameshift element pseudoknot plays a crucial role in viral replication. Using various techniques, especially NMR spectroscopy and in vitro frameshift assays, we have developed and optimized chemical probes that serve as fundamental structures for potential inhibitors targeting viral RNAs.
Betül Ceylan, Jennifer Adam, Sabrina Toews, Frank Kaiser, Jonas Dörr, Daniel Scheppa, Jan‐Niklas Tants, Alexandria Smart, Julian Schoth, Susanne Philipp, Elke Stirnal, Jan Ferner, Christian Richter, Sridhar Sreeramulu, Neva Caliskan, Andreas Schlundt, Julia E. Weigand, Michael Göbel, Anna Wacker, Harald Schwalbe   +19 more
wiley   +2 more sources

The glycosaminoglycan-binding chemokine fragment CXCL9(74–103) reduces inflammation and tissue damage in mouse models of coronavirus infection

Frontiers in Immunology
IntroductionPulmonary diseases represent a significant burden to patients and the healthcare system and are one of the leading causes of mortality worldwide.
Vivian Louise Soares Oliveira, Vivian Louise Soares Oliveira, Celso Martins Queiroz-Junior, Delphine Hoorelbeke, Felipe Rocha da Silva Santos, Ian de Meira Chaves, Mauro Martins Teixeira, Remo de Castro Russo, Paul Proost, Vivian Vasconcelos Costa, Sofie Struyf, Flávio Almeida Amaral   +11 more
doaj   +1 more source

A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses

npj Vaccines
The development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of SARS-CoV, MERS-CoV ...
S. Thimmiraju, R. Adhikari, J. R. Redd, Maria José Villar, Jungsoon Lee, Zhuyun Liu, Yi-Lin Chen, Suman Sharma, Amandeep Kaur, Nestor L. Uzcategui, S. Ronca, Wen-Hsiang Chen, J. Kimata, Bin Zhan, U. Strych, M. Bottazzi, P. Hotez, Jeroen Pollet   +17 more
semanticscholar   +1 more source

RNA structure-altering mutations underlying positive selection on Spike protein reveal novel putative signatures to trace crossing host-species barriers in Betacoronavirus

RNA Biology, 2022
Similar to other RNA viruses, the emergence of Betacoronavirus relies on cross-species viral transmission, which requires careful health surveillance monitoring of protein-coding information as well as genome-wide analysis. Although the evolutionary jump
Alexis Felipe Rojas-Cruz, J. Gallego-Gómez, C. Bermúdez-Santana   +2 more
semanticscholar   +1 more source