Results 11 to 20 of about 37,714 (159)

Betacoronavirus Infection Outbreak, São Paulo, Brazil, Fall 2023

Emerging Infectious Diseases
We report a human coronavirus OC43 infection outbreak in hospitalized patients and healthcare workers in São Paulo, Brazil, occurring after SARS-CoV-2 cases disappeared. Infection was associated with healthcare workers in 5 (29.4%) patients.
Tânia do Socorro Souza Chaves, Ana H. Perosa, Gabriela Barbosa, Diogo B. Ferreira, Nancy Bellei   +4 more
doaj   +3 more sources

Identification, Isolation, and Molecular Characterization of Betacoronavirus in Oryx leucoryx

Microbiology Spectrum, 2023
Coronaviruses (CoVs) are enveloped viruses with a large RNA genome (26 to 32 kb) and are classified into four genera: Alphacoronavirus, Betacoronavirus, Gammacoronavirus, and Deltacoronavirus.
Dan David, Jimmy Asiku, Nick Storm, Katya Lapin, Asaf Berkowitz, Anita Kovtunenko, Nir Edery, Roni King, Asaf Sol   +8 more
doaj   +3 more sources

Betacoronavirus-specific alternate splicing [PDF]

Genomics, 2021
AbstractViruses can subvert a number of cellular processes in order to block innate antiviral responses, and many viruses interact with cellular splicing machinery. SARS-CoV-2 infection was shown to suppress global mRNA splicing, and at least 10 SARS-CoV-2 proteins bind specifically to one or more human RNAs.
Guy Karlebach, Bruce Aronow, Stephen B. Baylin, Daniel Butler, Jonathan Foox, Shawn Levy, Cem Meydan, Christopher Mozsary, Amanda M Saravia-Butler, Deanne M Taylor, Eve Wurtele, Christopher E Mason, Afshin Beheshti, Peter N Robinson   +13 more
openaire   +4 more sources

Broad betacoronavirus neutralization by a stem helix–specific human antibody [PDF]

Science, 2021
Targeting a range of betacoranaviruses In the past 20 years, three highly pathogenic β-coronaviruses have crossed from animals to humans, including the most recent: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A spike protein that decorates these viruses has an S1 domain that binds host cell receptors and an S2 ...
Dora Pinto, Maximilian M. Sauer, Nadine Czudnochowski, Jun Siong Low, M. Alejandra Tortorici, Michael P. Housley, Julia Noack, Alexandra C. Walls, John E. Bowen, Barbara Guarino, Laura E. Rosen, Julia di Iulio, Josipa Jerak, Hannah Kaiser, Saiful Islam, Stefano Jaconi, Nicole Sprugasci, Katja Culap, Rana Abdelnabi, Caroline Foo, Lotte Coelmont, Istvan Bartha, Siro Bianchi, Chiara Silacci-Fregni, Jessica Bassi, Roberta Marzi, Eneida Vetti, Antonino Cassotta, Alessandro Ceschi, Paolo Ferrari, Pietro E. Cippà, Olivier Giannini, Samuele Ceruti, Christian Garzoni, Agostino Riva, Fabio Benigni, Elisabetta Cameroni, Luca Piccoli, Matteo S. Pizzuto, Megan Smithey, David Hong, Amalio Telenti, Florian A. Lempp, Johan Neyts, Colin Havenar-Daughton, Antonio Lanzavecchia, Federica Sallusto, Gyorgy Snell, Herbert W. Virgin, Martina Beltramello, Davide Corti, David Veesler   +51 more
openaire   +6 more sources

The coevolutionary mosaic of bat betacoronavirus emergence risk

Virus Evolution, 2022
Abstract Pathogen evolution is one of the least predictable components of disease emergence, particularly in nature. Here, building on principles established by the geographic mosaic theory of coevolution, we develop a quantitative, spatially explicit framework for mapping the evolutionary risk of viral emergence.
Seifert, Stephanie, Poisot, Timothée, Carlson, Colin, Muylaert, Renata, Forero, Norma, Albery, Gregory, Becker, Daniel   +6 more
openaire   +3 more sources

Structural mapping of antibody landscapes to human betacoronavirus spike proteins [PDF]

Science Advances, 2021
AbstractPreexisting immunity against seasonal coronaviruses (CoV) represents an important variable in predicting antibody responses and disease severity to Severe Acute Respiratory Syndrome CoV-2 (SARS-2) infections. We used electron microscopy based polyclonal epitope mapping (EMPEM) to characterize the antibody specificities against β-CoV spike ...
Sandhya Bangaru, Aleksandar Antanasijevic, Nurgun Kose, Leigh M. Sewall, Abigail M. Jackson, Naveenchandra Suryadevara, Xiaoyan Zhan, Jonathan L. Torres, Jeffrey Copps, Alba Torrents de la Peña, James E. Crowe, Andrew B. Ward   +11 more
openaire   +2 more sources

CoV-RBD121-NP Vaccine Candidate Protects against Symptomatic Disease following SARS-CoV-2 Challenge in K18-hACE2 Mice and Induces Protective Responses That Prevent COVID-19-Associated Immunopathology

Vaccines, 2021
We developed a SARS-CoV-2 vaccine candidate (CoV-RBD121-NP) comprised of a tobacco mosaic virus-like nanoparticle conjugated to the receptor-binding domain of the spike glycoprotein of SARS-CoV-2 fused to a human IgG1 Fc domain.
Jennifer K. DeMarco, Joshua M. Royal, William E. Severson, Jon D. Gabbard, Steve Hume, Josh Morton, Kelsi Swope, Carrie A. Simpson, John W. Shepherd, Barry Bratcher, Kenneth E. Palmer, Gregory P. Pogue   +11 more
doaj   +1 more source

A potential broad‐spectrum neutralizing antibody against Betacoronavirus

Journal of Medical Virology, 2023
AbstractThree pandemics caused by human Betacoronavirus had broken out in the past two decades. Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) was one of the novel epidemic strains which caused the third pandemic, coronavirus disease 2019 (COVID‐19), a global public health crisis.
Rong Wang, Jiazheng Guo, Jiansheng Lu, Peng Du, Jun Zhang, YunZhou Yu, Lei Chen, Zhiqi Xiong, Yuning Xiang, Xiaodan Ni, Junjie Xu, Zhixin Yang   +11 more
openaire   +2 more sources

Conserved host-pathogen interactions identify novel treatment options in betacoronavirus infections [PDF]

Signal Transduction and Targeted Therapy, 2021
Hypoxia is an underlying pathophysiological condition of a variety of devastating diseases, including acute ischemic stroke (AIS). We are faced with limited therapeutic options for AIS patients, and even after successful restoration of cerebral blood flow, the poststroke mortality is still high.
Lukassen, Soeren, Eils, Roland
openaire   +4 more sources

Comparative Study of Blue Light with Ultraviolet (UVC) Radiation on Betacoronavirus 1

Applied Sciences, 2023
The ongoing coronavirus pandemic requires more effective disinfection methods. Disinfection using ultraviolet light (UV), especially longer UVC wavelengths, such as 254 and 270/280 nm, has been proven to have virucidal properties, but its adverse effects
Kritika Vashishtha, Fengfeng Xi, Priya Dharmalingam, Alexandre Douplik   +3 more
doaj   +1 more source