Results 11 to 20 of about 45,973 (258)

Identification, Isolation, and Molecular Characterization of Betacoronavirus in Oryx leucoryx

Microbiology Spectrum, 2023
Coronaviruses (CoVs) are enveloped viruses with a large RNA genome (26 to 32 kb) and are classified into four genera: Alphacoronavirus, Betacoronavirus, Gammacoronavirus, and Deltacoronavirus.
Dan David, Jimmy Asiku, Nick Storm, Katya Lapin, Asaf Berkowitz, Anita Kovtunenko, Nir Edery, Roni King, Asaf Sol   +8 more
doaj   +4 more sources

Broad betacoronavirus neutralization by a stem helix–specific human antibody [PDF]

Science, 2021
Description Targeting a range of betacoranaviruses In the past 20 years, three highly pathogenic β-coronaviruses have crossed from animals to humans, including the most recent: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A spike protein
D. Pinto, M. M. Sauer, N. Czudnochowski, J. Low, M. A. Tortorici, M. P. Housley, Julia Noack, A. Walls, John E. Bowen, B. Guarino, Laura E. Rosen, J. di Iulio, Josipa Jerak, Hannah Kaiser, S. Islam, S. Jaconi, Nicole Sprugasci, K. Culap, R. Abdelnabi, C. Foo, Lotte Coelmont, I. Bartha, S. Bianchi, C. Silacci-Fregni, J. Bassi, R. Marzi, Eneida Vetti, Antonino Cassotta, A. Ceschi, P. Ferrari, Pietro E. Cippà, O. Giannini, S. Ceruti, C. Garzoni, A. Riva, F. Benigni, E. Cameroni, L. Piccoli, M. Pizzuto, M. Smithey, David Hong, A. Telenti, Florian A. Lempp, J. Neyts, C. Havenar-Daughton, A. Lanzavecchia, F. Sallusto, G. Snell, H. Virgin, M. Beltramello, D. Corti, D. Veesler   +51 more
semanticscholar   +8 more sources

A potential broad‐spectrum neutralizing antibody against Betacoronavirus [PDF]

Journal of Medical Virology, 2023
Three pandemics caused by human Betacoronavirus had broken out in the past two decades. Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) was one of the novel epidemic strains which caused the third pandemic, coronavirus disease 2019 (COVID‐19)
Rong Wang, Jiazheng Guo, Jiansheng Lu, Peng Du, Jun Zhang, Yun‐Zhou Yu, Lei Chen, Zhi‐Qi Xiong, Yuning Xiang, Xiaodan Ni, Junjie Xu, Zhi-Xin Yang   +11 more
semanticscholar   +4 more sources

The coevolutionary mosaic of bat betacoronavirus emergence risk

Virus Evolution, 2023
Pathogen evolution is one of the least predictable components of disease emergence, particularly in nature. Here, building on principles established by the geographic mosaic theory of coevolution, we develop a quantitative, spatially explicit framework ...
Norma R. Forero-Muñoz, R. Muylaert, Stephanie N. Seifert, Gregory F. Albery, Daniel J. Becker, Colin J. Carlson, T. Poisot   +6 more
semanticscholar   +4 more sources

Discovery and characterization of a pan-betacoronavirus S2-binding antibody.

Structure
Three coronaviruses have spilled over from animal reservoirs into the human population and caused deadly epidemics or pandemics. The continued emergence of coronaviruses highlights the need for pan-coronavirus interventions for effective pandemic ...
N. Johnson, Steven C. Wall, Kevin J. Kramer, Clinton M. Holt, S. Periasamy, S. Richardson, N. Manamela, Naveenchandra Suryadevara, Emanuele Andreano, Ida Paciello, Giulio Pierleoni, Giulia Piccini, Ying Huang, Pan Ge, James D. Allen, Naoko Uno, Andrea R. Shiakolas, Kelsey A. Pilewski, Rachel S. Nargi, Rachel E. Sutton, Alexandra A. Abu-Shmais, R. Parks, B. Haynes, R. Carnahan, James E. Crowe, E. Montomoli, R. Rappuoli, A. Bukreyev, Ted M. Ross, G. Sautto, J. McLellan, Ivelin S. Georgiev   +31 more
semanticscholar   +6 more sources

Cell surface nucleocapsid protein expression: A betacoronavirus immunomodulatory strategy

Proceedings of the National Academy of Sciences, 2023
Significance Despite the unprecedented global response to the COVID-19 pandemic, critical aspects of HCoV pathogenesis remain unclear, including mechanisms underlying immune evasion and viral manipulation of the cytokine network.
A. López-Muñoz, Jefferson J. S. Santos, J. Yewdell   +2 more
semanticscholar   +5 more sources

Alpha- and betacoronavirus cis-acting RNA elements

Current Opinion in Microbiology
Coronaviruses have exceptionally large RNA genomes and employ multiprotein replication/transcription complexes to orchestrate specific steps of viral RNA genome replication and expression. Most of these processes involve viral cis-acting RNA elements that are engaged in vital RNA-RNA and/or RNA-protein interactions.
Ramakanth Madhugiri, Nguyễn Hoàng Việt, Heiko Slanina, John Ziebuhr   +3 more
semanticscholar   +4 more sources

Betacoronavirus internal protein: role in immune evasion and viral pathogenesis. [PDF]

J Virol
ABSTRACT Betacoronaviruses express a small internal (I) protein that is encoded by the same subgenomic RNA (sgRNA) as the nucleocapsid (N) protein. Translation of the +1 reading frame of the N sgRNA through leaky ribosomal scanning leads to expression of the I protein.
Gunawardene CD, Wong L-YR.
europepmc   +4 more sources

Crystal structure of the membrane (M) protein from a bat betacoronavirus

PNAS Nexus, 2023
The membrane (M) protein is the most abundant structural protein of coronaviruses including MERS-CoV, SARS-CoV, and SARS-CoV-2, and plays a central role in virus assembly through its interaction with various partner proteins. However, mechanistic details
Xiaodong Wang, Yuwei Yang, Ziyi Sun, Xiaoming Zhou   +3 more
semanticscholar   +3 more sources

The role of lysosomes as intermediates in betacoronavirus PHEV egress from nerve cells

Journal of Virology, 2023
The traditional view that betacoronaviruses exit occurs via the constitutive secretory route has recently been questioned by studies suggesting that this process involves lysosomal exocytosis.
Zhenzhen Wang, Wenqi He, Caili Li, Yuzhu Chen, Zi Li, Yubo Jiao, Jing Zhang, Junchao Shi, Gaili Wang, Jiyu Guan, Kui Zhao, Deguang Song, Feng Gao, Yungang Lan   +13 more
semanticscholar   +4 more sources