Results 191 to 200 of about 41,690 (230)

Computational Prediction of RNA–RNA Interactions Between Small RNA Tracks From Betacoronavirus Nonstructural Protein 3 and Neurotrophin Genes During Infection of an Epithelial Lung Cancer Cell Line: Potential Role of Novel Small Regulatory RNA

Viruses, 2023
Whether RNA–RNA interactions of cytoplasmic RNA viruses, such as Betacoronavirus, might end in the biogenesis of putative virus-derived small RNAs as miRNA-like molecules has been controversial.
Clara Isabel Bermudez-Santana, Alexis Felipe Rojas-Cruz   +1 more
exaly   +3 more sources

A Potential Broad-Spectrum Neutralizing Antibody Against Betacoronavirus

Journal of Medical Virology, 2023
Three pandemics caused by human Betacoronavirus had broken out in the past two decades. Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) was one of the novel epidemic strains which caused the third pandemic, coronavirus disease 2019 (COVID‐19)
Jiazheng Guo, Zhixin Yang, Jiansheng Lu
exaly   +4 more sources

A Universal Design of Betacoronavirus Vaccines Against COVID-19, MERS, and SARS

Cell, 2020
Vaccines are urgently needed to control the ongoing pandemic COVID-19 and previously emerging MERS/SARS caused by coronavirus (CoV) infections. The CoV spike receptor-binding domain (RBD) is an attractive vaccine target but is undermined by limited ...
Gary W K Wong, Yuan Yuan, Mi Yang
exaly   +2 more sources

RNA Structure-Altering Mutations Underlying Positive Selection on Spike Protein Reveal Novel Putative Signatures to Trace Crossing Host-Species Barriers in Betacoronavirus

RNA Biology, 2022
: Similar to other RNA viruses, the emergence of Betacoronavirus relies on cross-species viral transmission, which requires careful health surveillance monitoring of protein-coding information as well as genome-wide analysis.
Juan C Gallego-Gomez, Clara Isabel Bermudez-Santana, Alexis Felipe Rojas-Cruz   +2 more
exaly   +2 more sources

Conserved Molecular Signatures in the Spike, Nucleocapsid, and Polymerase Proteins Specific for the Genus Betacoronavirus and Its Different Subgenera [PDF]

Genes, 2022
The genus Betacoronavirus, consisting of four main subgenera (Embecovirus, Merbecovirus, Nobecovirus, and Sarbecovirus), encompasses all clinically significant coronaviruses (CoVs), including SARS, MERS, and the SARS-CoV-2 virus responsible for current ...
Radhey S. Gupta, Bijendra Khadka
exaly   +2 more sources

Highly Conserved Betacoronavirus Sequences Are Broadly Recognized by Human T Cells

Cell
SUMMARY The COVID-19 pandemic highlighted the critical need for vaccine strategies capable of addressing emerging viral threats. Betacoronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome (MERS)
Alba Grifoni
exaly   +2 more sources

Is the Discovery of the Novel Human Betacoronavirus 2c EMC/2012 (HCoV-EMC) the Beginning of Another SARS-Like Pandemic?

Journal of Infection, 2012
Fouchier et al. reported the isolation and genome sequencing of a novel coronavirus tentatively named " human betacoronavirus 2c EMC/2012 (HCoV-EMC)" from a Saudi patient presenting with pneumonia and renal failure in June 2012.
Honglin Chen, Jasper Fuk-Woo Chan, Kwok-Yung Yuen   +2 more
exaly   +2 more sources

Loading of Oregano Oil in Natural Nanogel and Preliminary Studies on Its Antiviral Activity on Betacoronavirus 1

Molecules
Oregano oil was successfully encapsulated into chitosan–albumin nanogel via emulsification and electrostatic gelation. The system was characterized with a mean diameter around 26 nm, narrow size distribution (PDI = 0.242) and approximately 40 ...
Maya Margaritova Zaharieva, Daniela Kovacheva, Urania Georgopoulou   +2 more
exaly   +2 more sources

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Microtubule depolymerization limits porcine betacoronavirus PHEV replication

Veterinary Microbiology, 2022
Porcine hemagglutinating encephalomyelitis virus (PHEV) is a typical neurotropic betacoronavirus causing digestive disease and/or neurological dysfunction in neonatal pigs. Actin filaments have been identified to implicate in PHEV invasion, but the effects of viral infection on microtubules (MTs) cytoskeleton are unknown.
Qianyu, Zhou, Yungang, Lan, Yifei, Tang, Jiyu, Guan, Kui, Zhao, Feng, Gao, Wenqi, He, Zi, Li   +7 more
openaire   +2 more sources

First Molecular Evidence for Bat Betacoronavirus in Mindanao

Philippine Journal of Science, 2019
Coronaviruses (CoVs) are common agents of respiratory and gastrointestinal tract infections but are also considered as important emerging infectious disease (EID) agents that have led to global epidemics of severe respiratory disease. Human CoV EIDs have been proposed to have originated from bat CoVs (BtCoV).
Tampon, Nikki Vanesa, Rabaya, Ysabela Marie, Malbog, Kameela Monique, Burgos, Sammer, Bacus, Michael, Libre, Kemuel, Valila, Agape Shelley, Achondo, Marion John Michael, Siarot Onggo, Lowela, E. Murao, Lyre Anni   +9 more
openaire   +2 more sources