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Alpha- and betacoronavirus cis-acting RNA elements.

Current Opinion in Microbiology
Coronaviruses have exceptionally large RNA genomes and employ multiprotein replication/transcription complexes to orchestrate specific steps of viral RNA genome replication and expression. Most of these processes involve viral cis-acting RNA elements that are engaged in vital RNA-RNA and/or RNA-protein interactions.
Ramakanth Madhugiri, Hoang Viet Nguyen, H. Slanina, J. Ziebuhr   +3 more
semanticscholar   +4 more sources

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Microtubule depolymerization limits porcine betacoronavirus PHEV replication

Veterinary Microbiology, 2022
Porcine hemagglutinating encephalomyelitis virus (PHEV) is a typical neurotropic betacoronavirus causing digestive disease and/or neurological dysfunction in neonatal pigs. Actin filaments have been identified to implicate in PHEV invasion, but the effects of viral infection on microtubules (MTs) cytoskeleton are unknown.
Qianyu, Zhou, Yungang, Lan, Yifei, Tang, Jiyu, Guan, Kui, Zhao, Feng, Gao, Wenqi, He, Zi, Li   +7 more
openaire   +2 more sources

Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals.

Journal of Proteome Research, 2023
Host kinases play essential roles in the host cell cycle, innate immune signaling, the stress response to viral infection, and inflammation. Previous work has demonstrated that coronaviruses specifically target kinase cascades to subvert host cell ...
Ethan J. Fritch, Angie L. Mordant, T. S. Gilbert, C. Wells, Xuan Yang, Natalie K Barker, E. A. Madden, K. Dinnon, Yixuan J. Hou, Longping V. Tse, I. Castillo, A. Sims, Nathaniel J. Moorman, Premkumar Lakshmanane, T. Willson, Laura E. Herring, L. Graves, R. Baric   +17 more
semanticscholar   +1 more source

First Molecular Evidence for Bat Betacoronavirus in Mindanao

Philippine Journal of Science, 2019
Coronaviruses (CoVs) are common agents of respiratory and gastrointestinal tract infections but are also considered as important emerging infectious disease (EID) agents that have led to global epidemics of severe respiratory disease. Human CoV EIDs have been proposed to have originated from bat CoVs (BtCoV).
Tampon, Nikki Vanesa, Rabaya, Ysabela Marie, Malbog, Kameela Monique, Burgos, Sammer, Bacus, Michael, Libre, Kemuel, Valila, Agape Shelley, Achondo, Marion John Michael, Siarot Onggo, Lowela, E. Murao, Lyre Anni   +9 more
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Decision Tree for Classifying Betacoronavirus Species Using Amino Acid Frequencies

2021 IEEE International Conference on Artificial Intelligence and Computer Applications (ICAICA), 2021
Emerging infectious diseases have received significant global attention due to Betacoronaviruses. Researchers have used different names for the same Betacoronavirus genome or the same name for different genomes, resulting in erroneous identification.
Manal A. Alshehri, Manee M. Manee, Ghaida G. Alharthi, Mohanad A. Ibrahim, Badr M. Al-shomrani, Fahad H. Alqahtani   +5 more
openaire   +1 more source

The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation

Science Signaling
Coronaviruses rely on host proteases to activate the viral spike protein, which facilitates fusion with the host cell membrane and the release of viral genomic RNAs into the host cell cytoplasm.
Hyunjoon Kim, Yeonglim Kang, Semi Kim, Dongbin Park, Seo-Young Heo, Ji-Seung Yoo, Isaac Choi, Monford Paul Abishek N, Jae-Woo Ahn, Jeong-Sun Yang, Nayeon Bak, Kyeong Kyu Kim, Joo-Yeon Lee, Y. Choi   +13 more
semanticscholar   +1 more source

Modeling Inducible Epithelial Resistance Against Murine Betacoronavirus

C66. VIRAL INFECTIONS, COVID, AND BEYOND, 2023
M.K. Longmire, J. Pantaleón García, S.E. Evans   +2 more
openaire   +1 more source

Characterization of betacoronavirus HKU-1 and OC43 internal proteins using a prototypic coronavirus

bioRxiv
Chaminda D. Gunawardene, Isha Pandey, S. Chatterjee, Yoatzin Peñaflor-Téllez, Abby Odle, Adriana Messyasz, Ricardo Rajsbaum, Alan Sariol, L. Wong   +8 more
semanticscholar   +1 more source

Angiotensin-(1–7) decreases inflammation and lung damage caused by betacoronavirus infection in mice

Inflammation Research
E. B. S. Lima, A. F. Carvalho, Isabella Zaidan, A. H. A. Monteiro, Camila Cardoso, Edvaldo S Lara, F. S. Carneiro, L. C. Oliveira, Filipe Resende, F. R. Santos, L. P. Souza-Costa, I. Chaves, C. Queiroz-Junior, R. C. Russo, Robson A S Santos, Luciana P. Tavares, M. M. Teixeira, Vivian V Costa, L. Sousa   +18 more
semanticscholar   +1 more source

Inducible Epithelial Resistance Against Murine Betacoronavirus Lung Infection

B67. VIRAL RESPIRATORY INFECTIONS INSIGHTS
M.K. Longmire, J. Pantaleón García, S.E. Evans   +2 more
openaire   +1 more source