Broad betacoronavirus neutralization by a stem helix–specific human antibody [PDF]
Science, 2021 Targeting a range of betacoranaviruses In the past 20 years, three highly pathogenic β-coronaviruses have crossed from animals to humans, including the most recent: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A spike protein that decorates these viruses has an S1 domain that binds host cell receptors and an S2 ...
Nadine Czudnochowski +71 more
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Discovery of a Novel Coronavirus, China Rattus Coronavirus HKU24, from Norway Rats Supports the Murine Origin of Betacoronavirus 1 and Has Implications for the Ancestor of Betacoronavirus Lineage A [PDF]
Journal of Virology, 2015 ABSTRACTWe discovered a novelBetacoronaviruslineage A coronavirus, ChinaRattuscoronavirus (ChRCoV) HKU24, from Norway rats in China. ChRCoV HKU24 occupied a deep branch at the root of members ofBetacoronavirus 1, being distinct from murine coronavirus and human coronavirus HKU1.
Susanna K. P. Lau +10 more
openalex +7 more sources
Study of the Antiviral Activity of Adamantane-Containing Chemical Compounds
Антибиотики и Химиотерапия, 2022 Influenza and coronavirus infections are especially dangerous due to being capable of causing pandemics and clinical complications in the nervous and cardiovascular systems, as well as exacerbation of chronic diseases (diabetes mellitus, heart failure ...
I. I. LYUBIMOV +7 more
doaj +1 more source
Vaccines, 2021 We developed a SARS-CoV-2 vaccine candidate (CoV-RBD121-NP) comprised of a tobacco mosaic virus-like nanoparticle conjugated to the receptor-binding domain of the spike glycoprotein of SARS-CoV-2 fused to a human IgG1 Fc domain.
Jennifer K. DeMarco +11 more
doaj +1 more source
Alpha and Betacoronavirus Detection in Neotropical Bats from Northeast Brazil Suggests Wide Geographical Distribution and Persistence in Natural Populations. [PDF]
Animals (Basel)Figueiroa T +11 more
europepmc +2 more sources
The coevolutionary mosaic of bat betacoronavirus emergence risk
Virus Evolution, 2022 Abstract Pathogen evolution is one of the least predictable components of disease emergence, particularly in nature. Here, building on principles established by the geographic mosaic theory of coevolution, we develop a quantitative, spatially explicit framework for mapping the evolutionary risk of viral emergence.
Seifert, Stephanie +6 more
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COVID-19: perspectivas terapéuticas en IL-17/Th17
Iatreia, 2021 Las células T helper-17 (Th17) y la interleuquina (IL) IL-17 desempeñan funciones biológicas relacionadas con la protección contra infecciones por bacterias extracelulares y hongos.
Franky Úsuga-Úsuga +2 more
doaj +1 more source
COVID-19: a perspective focus on IL-17/Th17
Iatreia, 2022 Interleukin 17 (IL-17)-producing helper T cells (Th17) and IL-17 play an important role in the defense against extracellular bacteria and fungi; however, persistent secretion of IL-17 is also an important component in the pathogenesis of many ...
Úsuga-Úsuga, Franky +2 more
doaj +1 more source
Novel Betacoronavirus in Dromedaries of the Middle East, 2013 [PDF]
Emerging Infectious Diseases, 2014 In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were detected in 52% of 59 dromedary serum samples tested.
Mareena, R +13 more
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Structural mapping of antibody landscapes to human betacoronavirus spike proteins [PDF]
Science Advances, 2021 AbstractPreexisting immunity against seasonal coronaviruses (CoV) represents an important variable in predicting antibody responses and disease severity to Severe Acute Respiratory Syndrome CoV-2 (SARS-2) infections. We used electron microscopy based polyclonal epitope mapping (EMPEM) to characterize the antibody specificities against β-CoV spike ...
Zhan X +12 more
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