Results 21 to 30 of about 46,357 (231)

A potential broad‐spectrum neutralizing antibody against Betacoronavirus

Journal of Medical Virology, 2023
Three pandemics caused by human Betacoronavirus had broken out in the past two decades. Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) was one of the novel epidemic strains which caused the third pandemic, coronavirus disease 2019 (COVID‐19)
Rong Wang, Jiazheng Guo, Jiansheng Lu, Peng Du, Jun Zhang, Yunzhou Yu, Lei Chen, Zhiqi Xiong, Yuning Xiang, Xiaodan Ni, Junjie Xu, Zhixin Yang   +11 more
semanticscholar   +3 more sources

Loading of Oregano Oil in Natural Nanogel and Preliminary Studies on Its Antiviral Activity on Betacoronavirus 1. [PDF]

Molecules
Oregano oil was successfully encapsulated into chitosan–albumin nanogel via emulsification and electrostatic gelation. The system was characterized with a mean diameter around 26 nm, narrow size distribution (PDI = 0.242) and approximately 40 ...
Radeva L, Zaharieva MM, Naydenska S, Foka P, Karamichali E, Koufogeorgou EI, Georgopoulou U, Philipov S, Kroumov A, Najdenski H, Spassova I, Kovacheva D, Yoncheva K.   +12 more
europepmc   +2 more sources

Pre-pandemic artificial MERS analog of polyfunctional SARS-CoV-2 S1/S2 furin cleavage site domain is unique among spike proteins of genus Betacoronavirus. [PDF]

BMC Genom Data
SARS-CoV-2 spike (S) glycoprotein furin cleavage site is a key determinant of SARS-CoV-2 virulence and COVID-19 pathogencity. Located at the S1/S2 junction, it is unique among sarbecoviruses but frequently found among betacoronaviruses.
Lisewski AM.
europepmc   +2 more sources

Discovery and characterization of a pan-betacoronavirus S2-binding antibody.

Structure
Three coronaviruses have spilled over from animal reservoirs into the human population and caused deadly epidemics or pandemics. The continued emergence of coronaviruses highlights the need for pan-coronavirus interventions for effective pandemic ...
N. Johnson, Steven C. Wall, Kevin J. Kramer, Clinton M. Holt, S. Periasamy, S. Richardson, N. Manamela, Naveenchandra Suryadevara, Emanuele Andreano, Ida Paciello, Giulio Pierleoni, Giulia Piccini, Ying Huang, Pan Ge, James D. Allen, Naoko Uno, Andrea R. Shiakolas, Kelsey A. Pilewski, Rachel S. Nargi, Rachel E. Sutton, Alexandra A. Abu-Shmais, R. Parks, B. Haynes, R. Carnahan, James E. Crowe, E. Montomoli, R. Rappuoli, A. Bukreyev, Ted M. Ross, G. Sautto, J. McLellan, Ivelin S. Georgiev   +31 more
semanticscholar   +6 more sources

Betacoronavirus Infection Outbreak, São Paulo, Brazil, Fall 2023

Emerging Infectious Diseases
We report a human coronavirus OC43 infection outbreak in hospitalized patients and healthcare workers in São Paulo, Brazil, occurring after SARS-CoV-2 cases disappeared. Infection was associated with healthcare workers in 5 (29.4%) patients.
Tânia do Socorro Souza Chaves, Ana H. Perosa, Gabriela Barbosa, Diogo B. Ferreira, Nancy Bellei   +4 more
doaj   +3 more sources

Detection of avian, murine, bovine, shrew, and bat coronaviruses in wild mammals from Mexico [PDF]

Virology Journal
Coronaviruses infect a wide range of animal and human hosts. Some human coronaviruses, such as SARS-CoV, MERS-CoV, and SARS-CoV-2, originated in animals, with bats often serving as ancestral hosts.
Jocelyn Medina-Gudiño, Yolanda López-Vidal, J. Adolfo Pardo-Tovar, Lauro Velázquez-Salinas, Francisco Javier Basurto-Alcántara   +4 more
doaj   +2 more sources

DNA vaccine targeting betacoronavirus spike protein blocks neuroinvasion and neuroinflammation in swine via dual antiviral-immunomodulatory action. [PDF]

NPJ Vaccines
Porcine hemagglutinating encephalomyelitis virus (PHEV), a neurotropic betacoronavirus, causes fatal neurological disease in piglets, yet no licensed vaccines exist.
Yu H, Shi J, Fu G, Cao Z, Qiu R, Zhao T, Zhang J, Lan Y, Guan J, Zhao K, Gao F, He W, Li Z.   +12 more
europepmc   +2 more sources

Paradoxical G-quadruplex distribution in coronavirus genomes reveals functional constraints and antiviral therapeutic opportunities [PDF]

Virus Research
We computationally characterized G-quadruplex (G4) distributions across 31 coronavirus genomes to identify conserved structural features as potential antiviral therapeutic targets.
Masato Tanigawa, Takafumi Iwaki
doaj   +2 more sources

E3 Ubiquitin Ligase Smurf1 Regulates the Inflammatory Response in Macrophages and Attenuates Hepatic Damage during Betacoronavirus Infection. [PDF]

Pathogens
The E3 ubiquitin ligase Smurf1 catalyzes the ubiquitination and proteasomal degradation of several protein substrates related to inflammatory responses and antiviral signaling. This study investigated the role of Smurf1 in modulating inflammation induced
Souza-Costa LP, Santos FRS, Pimenta JC, Queiroz-Junior CM, Tana FL, Teixeira DC, Couto MGG, Oliveira NFM, Pereira RD, Beltrami VA, Costa PAC, Lacerda LSB, Andrade-Chaves JT, Guimarães PPG, Aguiar RS, Teixeira MM, Costa VV, Franco LH.   +17 more
europepmc   +2 more sources

Crystal structure of the membrane (M) protein from a bat betacoronavirus

PNAS Nexus, 2023
The membrane (M) protein is the most abundant structural protein of coronaviruses including MERS-CoV, SARS-CoV, and SARS-CoV-2, and plays a central role in virus assembly through its interaction with various partner proteins. However, mechanistic details
Xiaodong Wang, Yuwei Yang, Ziyi Sun, Xiaoming Zhou   +3 more
semanticscholar   +3 more sources