Results 51 to 60 of about 37,714 (159)

Identification of the Fusion Peptide-Containing Region in Betacoronavirus Spike Glycoproteins [PDF]

Journal of Virology, 2016
ABSTRACT The fusion peptides (FP) play an essential role in fusion of viral envelope with cellular membranes. The location and properties of the FPs in the spike (S) glycoproteins of different coronaviruses (CoV) have not yet been determined. Through amino acid sequence analysis of S proteins of representative CoVs, we identified
Xiuyuan, Ou, Wangliang, Zheng, Yiwei, Shan, Zhixia, Mu, Samuel R, Dominguez, Kathryn V, Holmes, Zhaohui, Qian   +6 more
openaire   +2 more sources

Immunodominant antibody responses directed to SARS-CoV-2 hotspot mutation sites and risk of immune escape

Frontiers in Immunology, 2023
IntroductionConsidering the likely need for the development of novel effective vaccines adapted to emerging relevant CoV-2 variants, the increasing knowledge of epitope recognition profile among convalescents and afterwards vaccinated with identification
Jamille Ramos Oliveira, Jamille Ramos Oliveira, Jamille Ramos Oliveira, Cesar Manuel Remuzgo Ruiz, Rafael Rahal Guaragna Machado, Jhosiene Yukari Magawa, Jhosiene Yukari Magawa, Jhosiene Yukari Magawa, Isabela Pazotti Daher, Isabela Pazotti Daher, Isabela Pazotti Daher, Alysson Henrique Urbanski, Gabriela Justamante Händel Schmitz, Gabriela Justamante Händel Schmitz, Helen Andrade Arcuri, Marcelo Alves Ferreira, Greyce Luri Sasahara, Giuliana Xavier de Medeiros, Roberto Carlos Vieira Silva Júnior, Edison Luiz Durigon, Edison Luiz Durigon, Silvia Beatriz Boscardin, Daniela Santoro Rosa, Daniela Santoro Rosa, Deborah Schechtman, Helder I. Nakaya, Helder I. Nakaya, Edecio Cunha-Neto, Edecio Cunha-Neto, Edecio Cunha-Neto, Gabriele Gadermaier, Jorge Kalil, Jorge Kalil, Jorge Kalil, Verônica Coelho, Verônica Coelho, Verônica Coelho, Keity Souza Santos, Keity Souza Santos, Keity Souza Santos   +39 more
doaj   +1 more source

Structural proteins in the mechanisms of betacoronavirus virion assembly

The Ukrainian Biochemical Journal, 2022
The emergence of SARS-CoV-2 caused an urgent need to investigate the molecular mechanisms of its reproduction. However, the detailed step-by-step mechanism of SARS-CoV-2 virion assembly has not been described yet. In the presented review the data on the role of structural proteins in the efficient assembly of betacoronavirus particles are analyzed.
I. Zaloilo, О. Zaloilo, Y. Rud, L. Buchatskyi   +3 more
openaire   +1 more source

COVID-19 y la pandemia global causada por un nuevo coronavirus

Universidad y Salud, 2020
Introducción: COVID-19 es una enfermedad respiratoria inédita que se reportó inicialmente como una neumonía atípica en diciembre de 2019. SARS-CoV-2, agente etiológico de esta patología, probablemente originado a partir de un virus de murciélago.
Mario Fernando Benavides-Rosero
doaj   +1 more source

Detecting and Monitoring Porcine Hemagglutinating Encephalomyelitis Virus, an Underresearched Betacoronavirus

mSphere, 2020
There is a paucity of information concerning the ecology of porcine hemagglutinating encephalomyelitis virus (PHEV) in commercial swine herds. This study provided evidence that PHEV infection is endemic and highly prevalent in U.S. swine herds. These results raised questions for future studies regarding the impact of endemic PHEV on swine health and ...
Mora-Díaz, Juan Carlos, Magtoto, Ronaldo, Houston, Elizabeth, Baum, David, Carrillo-Ávila, José Antonio, Temeeyasen, Gun, Zimmerman, Jeff, Piñeyro, Pablo, Giménez-Lirola, Luis   +8 more
openaire   +5 more sources

Crystal structure of the membrane (M) protein from a bat betacoronavirus

PNAS Nexus, 2023
Abstract The membrane (M) protein is the most abundant structural protein of coronaviruses including MERS-CoV, SARS-CoV, and SARS-CoV-2, and plays a central role in virus assembly through its interaction with various partner proteins. However, mechanistic details about how M protein interacts with others remain elusive due to lack of ...
Xiaodong Wang, Yuwei Yang, Ziyi Sun, Xiaoming Zhou   +3 more
openaire   +2 more sources

The effect of early-stage public health policies in the transmission of COVID-19 for South American countries

Revista Panamericana de Salud Pública, 2020
Objectives. The analysis of transmission dynamics is crucial to determine whether mitigation or suppression measures reduce the spread of coronavirus disease 2019 (COVID-19). This study sought to estimate the basic (R0) and time-varying (Rt) reproduction
Bryan Valcarcel, Jose L. Avilez, J. Smith Torres-Roman, Julio A. Poterico, Janina Bazalar-Palacios, Carlo La Vecchia   +5 more
doaj   +1 more source

Porcine Hemagglutinating Encephalomyelitis Virus Co-Opts Multivesicular-Derived Exosomes for Transmission

mBio, 2023
Porcine hemagglutinating encephalomyelitis virus (PHEV) is a member of the family Coronaviridae, genus Betacoronavirus, and subgenus Embecovirus that causes neurological disorders, vomiting and wasting disease (VWD), or influenza-like illness (ILI) in ...
Zi Li, Shaoqian Mu, Yihan Tian, Junchao Shi, Yungang Lan, Jiyu Guan, Kui Zhao, Feng Gao, Wenqi He   +8 more
doaj   +1 more source

Sars-Cov-2 And Betacoronavirus : What Have We Learned In 8 Months? [PDF]

Postępy Mikrobiologii - Advancements of Microbiology, 2020
Abstract In 2019, a new human pandemic coronavirus (SARS-CoV-2) emerged in Wuhan, China. We present the knowledge about SARS-CoV-2 compared to SARS-CoV and MERS-CoV. The SARS-CoV-2 is similar to other coronaviruses, nevertheless, differences were observed.
Kwiatek, Agnieszka, Adamczyk-Popławska, Monika   +1 more
openaire   +2 more sources

Recombination and Positive Selection Differentially Shaped the Diversity of Betacoronavirus Subgenera [PDF]

Viruses, 2020
The Betacoronavirus genus of mammal-infecting viruses includes three subgenera (Sarbecovirus, Embecovirus, and Merbecovirus), in which most known human coronaviruses, including SARS-CoV-2, cluster. Coronaviruses are prone to host shifts, with recombination and positive selection possibly contributing to their high zoonotic potential.
Forni D, Cagliani R, Sironi M
openaire   +4 more sources