Metabolomic Biomarkers of Pulmonary Fibrosis in COVID‐19 Patients One Year After Hospital Discharge
ABSTRACT Coronavirus disease 2019 (COVID‐19) global pandemic has affected more than 600 million people up to date. The symptomatology and severity of COVID‐19 are very broad, and there are still concerns about the long‐term sequelae that it can have on discharged patients.
Marina Botello‐Marabotto+11 more
wiley +1 more source
Torsional twist of the SARS‐CoV and SARS‐CoV‐2 SUD‐N and SUD‐M domains
Abstract Coronavirus non‐structural protein 3 (nsp3) forms hexameric crowns of pores in the double membrane vesicle that houses the replication–transcription complex. Nsp3 in SARS‐like viruses has three unique domains absent in other coronavirus nsp3 proteins.
Monica Rosas‐Lemus+13 more
wiley +1 more source
Investigation of the Blood Microbiome in Horses With Fever of Unknown Origin
ABSTRACT Background Fever of unknown origin (FUO) without a respiratory component is a frequent clinical presentation in horses. Multiple pathogens, both tick‐borne and enteric, can be involved as etiologic agents. An additional potential mechanism is intestinal barrier dysfunction.
Yining Sun+18 more
wiley +1 more source
A framework to predict zoonotic hosts under data uncertainty: A case study on betacoronaviruses
Abstract Modelling approaches aimed at identifying unknown hosts of zoonotic pathogens have the potential to make high‐impact contributions to global strategies for zoonotic risk surveillance. However, geographical and taxonomic biases in host–pathogen associations affect the reliability of models and their predictions.
Andrea Tonelli+3 more
wiley +1 more source
ABSTRACT HCoV‐HKU1 diversity and evolution were scarcely studied. We performed next‐generation sequencing (NGS) and analysis of HCoV‐HKU1 genomes over 5 years. NGS used Illumina technology on NovaSeq 6000 following whole genome PCR amplification by an in‐house set of primers designed using Gemi and PrimalScheme.
Houmadi Hikmat+9 more
wiley +1 more source
Novel coronavirus SARS-CoV-2 in the context of global epidemiology of coronavirus infections
The seemingly unexpected appearance of SARS-CoV-2 in China and its subsequent rapid spread throughout the world make us think seriously about the coronavirus threat emanating from natural foci in the territory of our country.
M. V. Supotnitskiy
doaj +1 more source
Conserved host-pathogen interactions identify novel treatment options in betacoronavirus infections [PDF]
Soeren Lukassen, Roland Eils
openalex +1 more source
Dynamic Combinatorial Chemistry Unveils Nsp10 Inhibitors with Antiviral Potential Against SARS‐CoV‐2
This study investigates antiviral strategies targeting SARS‐CoV‐2 by disrupting the protein‐protein interactions of Nsp10 with Nsp14 and Nsp16, which are essential for viral survival. It employs target‐directed dynamic combinatorial chemistry for the identification and synthesis of inhibitors.
Ravindra P. Jumde+15 more
wiley +1 more source
Understanding the role of geographic exposure to coronaviruses in the development of cross‐reactive immunity is important for pandemic modeling and interpretation of serology. In this work, the reactivity of U.S. pandemic samples, pre‐pandemic Cambodian samples, and pre‐pandemic U.S.
Parinaz Fathi+21 more
wiley +1 more source
Inhibition of Human Respiratory Influenza A Virus and Human Betacoronavirus-1 by the Blend of Double-Standardized Extracts of Aronia melanocarpa (Michx.) Elliot and Sambucus nigra L. [PDF]
Michał Ochnik+6 more
openalex +1 more source