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Betahistine for Menière's disease
Audiological Medicine, 2012Betahistine, a histamine H1 agonist and H3 antagonist, has been used for the pharmacotherapy of Meniere's disease for many decades. Earlier its mode of action and efficacy, in particular in low dosages, were the subject of controversy mainly because valid experimental or clinical data were not available.
Michael Strupp +5 more
openaire +1 more source
Otology and Neurotology
HYPOTHESIS Intratympanic (IT) application of betahistine diffuses to the inner ear after 15 minutes of exposure and exhibits no ototoxicity. BACKGROUND Management of Menière disease involves oral treatment with betahistine; however, is mitigated by a ...
Jennifer L. Spiegel +6 more
semanticscholar +1 more source
HYPOTHESIS Intratympanic (IT) application of betahistine diffuses to the inner ear after 15 minutes of exposure and exhibits no ototoxicity. BACKGROUND Management of Menière disease involves oral treatment with betahistine; however, is mitigated by a ...
Jennifer L. Spiegel +6 more
semanticscholar +1 more source
Neuroscience Letters
Dysfunction of the vestibular nuclei, which can arise from various causes, is a common problem, affecting more than a third of people over 40. Its characteristic symptom is vestibular vertigo.
N. Zhuikova +5 more
semanticscholar +1 more source
Dysfunction of the vestibular nuclei, which can arise from various causes, is a common problem, affecting more than a third of people over 40. Its characteristic symptom is vestibular vertigo.
N. Zhuikova +5 more
semanticscholar +1 more source
Betahistine Normalizes the State of Mitochondria in Deiters Neurons during Vestibular Stimulation
BiophysicsI. Mikheeva +5 more
semanticscholar +1 more source