Results 211 to 220 of about 152,115 (284)

Durvalumab–Tremelimumab in Advanced Hepatocellular Carcinoma: Real‐World Data From the LOR‐HCC (Lombardy Real‐World HCC Group)

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background and Aim Dual immune checkpoint blockade with tremelimumab plus durvalumab (STRIDE) is an established first‐line therapy for unresectable hepatocellular carcinoma (uHCC); however, real‐world evidence on its safety, toxicity kinetics and liver function dynamics remains limited.
Andrea Casadei‐Gardini, Lorenzo Canova, Federica Tosi, Silvia Camera, Elisa Bocchero, Pietro Pozzoni, Martina Torchio, Salvatore Corallo, Daniela Costantino, Annamaria Stagno, Giulia Grizzi, Rita Gengarle, Gianluca Tomasello, Nasim Ansarin, Mariangela Bruccoleri, Katia Bencardino, Mara Persano, Martina Pino, Alessia Riva, Sara Vavassori, Lorenzo Argiento, Chiara Mazzarelli, Massimo De Giorgio, Elena Rota Caremoli, Margherita Rimini, Tiziana Pressiani, Lorenza Rimassa, Massimo Iavarone   +27 more
wiley   +1 more source

Biomarkers of Diabetic Macular Edema on Optical Coherence Tomography After Cataract Surgery. [PDF]

J Vitreoretin Dis
Tran T, Goh J, Rogers S, Qureshi S, Lim LL.   +4 more
europepmc   +1 more source

The Prognostic and Biological Value of PGF‐Based H&E Pathomics in Hepatocellular Carcinoma

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Purpose Placental growth factor (PGF) is associated with the progression of hepatocellular carcinoma (HCC), but current research on this relationship remains limited. This study aims to establish a pathomics model for predicting PGF expression levels in H&E‐stained HCC sections, and to explore its prognostic relevance and underlying molecular ...
Long Chen, Xusheng Zhang, Kejun Liu, Weihu Ma, Ling Ding, Shicai Liang, Xuebo Wang, Bendong Chen   +7 more
wiley   +1 more source

Multi‐Omics and Machine Learning‐Uncovered FLT1‐Mediated Epithelial‐Endothelial Crosstalk in Cellular Senescence Driving Clear Cell Renal Cell Carcinoma Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
This study integrates multi‐omics data and machine learning to reveal FLT1 as a central mediator of epithelial‐endothelial crosstalk in clear cell renal cell carcinoma (ccRCC). We demonstrate that FLT1‐associated signaling promotes a senescence‐enriched tumor microenvironment, driving malignant progression. Spatial and single‐cell analyses confirm FLT1
Mouyuan Sun, Huchao Mao, Yaxian Luo, Mei Yang, Zhixu He, Shuangyang Li, Zhichao Liu, Lianjie Peng, Quanjie Zhang, Jingyu Zhang, Yan Zhang   +10 more
wiley   +1 more source

Bevacizumab and Tocotrienol in Recurrent Platinum-Resistant Ovarian Cancer, and the Role of HOXA9 as a Prognostic Biomarker. [PDF]

Diseases
Graae EE, Faaborg L, Andersen RF, Fokdal LU, Thomsen CB.   +4 more
europepmc   +1 more source

Efficacy of the combined use of bevacizumab and irinotecan in a human colorectal cancer xenograft model analysed by SPECT imaging [PDF]

, 2011
Geboes, Karen, Laurent, Stéphanie, Peeters, Marc, Van Damme, Nancy, Van De Wiele, Christophe, VANGESTEL, CHRISTEL   +5 more
core   +1 more source

In Vitro Evaluation of PARP1 Inhibitor Olaparib‐Cyanine Dye Conjugate for the Treatment of Glioblastoma

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Inhibition of DNA damage repair is a common mechanism to induce cancer cell death and, therefore, to treat cancers such as breast, prostate and ovarian cancer. This approach, although very attractive, has not been feasible for treating brain tumours due to the stringent structural features necessary for pharmaceutical agents to cross the blood–brain ...
Carina Dumo, Faheem, Peter J. Choi, Nicholas J. Pederson, Yuge Liu, Mike Dragunow, Thomas I‐H. Park, Katharine L. Diehl, Jiney Jose   +8 more
wiley   +1 more source

Ivonescimab combined with chemotherapy for the treatment of metastatic cervical cancer: A case report and literature review. [PDF]

Hum Vaccin Immunother
Xu M, Qiu S, Zhou J, Zhang Y.
europepmc   +1 more source

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, Volume 13, Issue 20, 9 April 2026.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, Volume 13, Issue 21, 13 April 2026.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source