Results 231 to 240 of about 104,823 (289)

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Phase II randomised study of magrolimab combined with bevacizumab-FOLFIRI in patients with previously treated advanced inoperable metastatic colorectal cancer. [PDF]

ESMO Gastrointest Oncol
Fakih M, Gill S, Sampat K, Chan DL, Fisher G, Cruz-Correa M, Lenz HJ, Garcia-Alfonso P, Forget F, Lonardi S, Krauss J, Chen E, Cubillo Gracian A, Liu Y, van Buuren N, Shao J, Dong M, Chen A, Tejani M, Hecht JR.   +19 more
europepmc   +1 more source

A Comprehensive Disproportionality Analysis of Drug‐Related Head Injury Reports Using the FAERS Database

Brain and Behavior, Volume 16, Issue 6, June 2026.
ABSTRACT Objective This study aimed to identify and characterize drugs associated with reports of head injury through a comprehensive analysis of the FDA Adverse Event Reporting System (FAERS) database. Methods A retrospective disproportionality analysis was conducted on FAERS reports from 2004 to 2023.
Jiaqi Guo, Luming Wei, Junfeng Liu, Jimei Zhang, He Wang, Wanjun Lu   +5 more
wiley   +1 more source

Advances in Phase III Clinical Trials and Future Challenges of Targeted Therapy in Advanced Ovarian Cancer. [PDF]

Cancer Manag Res
Zhang L, Qiao R, Chen M, Yang Z, Gong M, Yu R.   +5 more
europepmc   +1 more source

Treatment Advances in Gynecologic Cancers: Insights From Recent Clinical Trials

Cancer Innovation, Volume 5, Issue 3, June 2026.
Overview of immunotherapy and antibody‐drug conjugates, and their mechanism against cancer. (The Graphical Abstract Image was created with BioRender.) ABSTRACT Gynecologic cancers remain a major global health burden for women. Their management has evolved toward a gynecologic oncologist‐led multimodal paradigm.
Yiyang Shen, Xiaofei Jiao, Yuanjia Wen, Zikun Peng, Xuejiao Zhao, Jiahao Liu, Qinglei Gao   +6 more
wiley   +1 more source

Poly(ADP-ribose) polymerase inhibitor maintenance therapy in ovarian cancer: a single-center retrospective study. [PDF]

Front Oncol
Pence S, Dyson K, Waters K, Elliott JO, Rath K, Pierce S, Harper A, Calo C, Clements AE.   +8 more
europepmc   +1 more source

Safely Treating a Pulmonary Embolism in a Patient With Hereditary Hemorrhagic Telangiectasia: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Hereditary Hemorrhagic Telangiectasia (HHT) is a rare autosomal dominant bleeding disorder. The incidence of venous thromboembolisms among HHT patients is significantly greater than the general population. However, providing therapeutic anticoagulation in patients with an increased propensity for bleeding creates a clinical dilemma.
Christina Carfagnini, Manasa Kandula
wiley   +1 more source

Bevacizumab withdrawal-associated cortical hyperperfusion in recurrent high-grade astrocytoma: An underrecognized MRI pitfall. [PDF]

Radiol Case Rep
Coelho A, Chen Z, Sidani C, Abrams KJ, Freitas LF.   +4 more
europepmc   +1 more source

Docetaxel‐Induced Serositis Mimicking Malignant Pleural Effusion

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Pleural effusions are common in patients with cancer. Although their development may signal progressive malignant disease, drug‐induced effusions are a rare and often overlooked cause of exudative pleural effusions. We describe a 50‐year‐old woman with recurrent granulosa cell tumor of the ovary who developed bilateral pleural and pericardial ...
Muhammad Anees, Kevin Chiu, Stephen Goertzen, Carlos A. Jimenez, Saadia A. Faiz   +4 more
wiley   +1 more source