Results 241 to 250 of about 216,339 (397)

Tumor Endothelial Cells Induce M2 Macrophage Polarization via IL‐4, Enhancing Tumor Growth in Hepatocellular Carcinoma

Cancer Science, EarlyView.
Tumor endothelial cells (TECs) promote the polarization of macrophages to M2 subtype by secreting IL‐4. Downregulation of IL‐4 in TECs suppressed M2 polarization and tumor progression. A high abundance of both TECs and M2 macrophages in HCC specimens is associated with poor prognosis.
Daijiro Matoba, Takehiro Noda, Shogo Kobayashi, Yoshihiro Sakano, Kenichi Matsumoto, Chihiro Yamanaka, Kazuki Sasaki, Shinichiro Hasegawa, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Hidenori Takahashi, Tadafumi Asaoka, Junzo Shimizu, Hisashi Wada, Yuichiro Doki, Hidetoshi Eguchi   +17 more
wiley   +1 more source

Efficacy and Safety of T‐DXd in HER2+ and Low/Zero Metastatic BCBM: A Retrospective Multicenter Real‐World Study

Cancer Science, EarlyView.
This real‐world study provides critical evidence supporting the efficacy and safety of T‐DXd in HER2‐positive and HER2‐low breast cancer brain metastases (BCBM), including patients with active/symptomatic disease, leptomeningeal involvement, and poor performance status, thereby addressing unmet needs in clinical practice.
Qingru Zhou, Yuanyuan Li, Ni He, Guorong Zou, Mengqian Ni, Lulu Zhang, Shu Dun, Zhanhong Chen, Kejun Liu, Yabing Cao, Jiajia Huang, Fei Xu, Zhongyu Yuan, Shusen Wang, Yanxia Shi, Yonggao Mou, Anli Yang, Lixia Li, Xin An   +18 more
wiley   +1 more source

Combined treatment of a juxtapapillary retinal capillary haemangioma with intravitreal bevacizumab and photodynamic therapy [PDF]

, 2007
Focke Ziemssen, M. Voelker, W. Inhoffen, K. U. Bartz-Schmidt, Faik Gelişken   +4 more
openalex   +1 more source

Complete and Early Vitrectomy for Sterile Endophthalmitis After Bevacizumab: A Case Series. [PDF]

Cureus
Kudasiewicz-Kardaszewska A, Ozimek MA, Kardaszewska A, Kardaszewski P, Kapturska N, Jamontt K, Boninska K, Cisiecki S.   +7 more
europepmc   +1 more source

Intravitreal bevacizumab (Avastin) for the treatment of bilateral acquired juxtafoveal retinal telangiectasis associated with choroidal neovascular membrane [PDF]

, 2007
Joke Ruys, J. J. De Laey, Y Vanderhaeghen, Elisabeth Van Aken   +3 more
openalex   +1 more source

Impact of TP53, KRAS, and APC Mutations on Neoadjuvant Chemotherapy Outcomes in Locally Advanced Rectal Cancer

Cancer Science, EarlyView.
Genetic profiling of TP53, KRAS, and APC mutations reveals potential as predictors of neoadjuvant chemotherapy efficacy in locally advanced rectal cancer, aiding personalized treatment strategies to improve survival and reduce recurrence risks. ABSTRACT Despite recent advances in neoadjuvant strategies for locally advanced rectal cancer (LARC), optimal
Tomohiro Takeda, Tatsuya Shonaka, Mishie Tanino, Katsuro Enomoto, Shoichiro Mizukami, Masahide Otani, Mizuho Ohara, Chikayoshi Tani, Kimiharu Hasegawa, Takahiro Ishii, Ayumu Sugitani, Chiho Maeda, Yusuke Ono, Yuji Uno, Nobue Tamamura, Shin‐ichi Chiba, Yusuke Mizukami, Hideki Yokoo   +17 more
wiley   +1 more source

Bevacizumab-Associated Enterocutaneous Fistula: A Case Report and Management Review. [PDF]

Cureus
Wallace ML, Akbarshahi L, Bond M, Yangandawele T, Howdieshell T.   +4 more
europepmc   +1 more source

Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2017
A. Venook, D. Niedzwiecki, H. Lenz, F. Innocenti, B. Fruth, J. Meyerhardt, D. Schrag, C. Greene, B. O'Neil, J. Atkins, S. Berry, B. Polite, E. O’Reilly, R. Goldberg, H. Hochster, R. Schilsky, M. Bertagnolli, A. El-Khoueiry, P. Watson, A. Benson, D. Mulkerin, R. Mayer, C. Blanke   +22 more
semanticscholar   +1 more source

DNA Methylation in Ovarian and Endometrial Cancers: Predictive and Mechanistic Roles in PARP Inhibitor and ICI Response

Cancer Science, EarlyView.
Cancer treatment is shifting from an organ‐based framework to one driven by biological phenotypes, and DNA methylation is increasingly recognized as an important factor that governs tumor behavior beyond genetic mutations. In gynecologic cancers, BRCA1 and MLH1 promoter methylation–associated homologous recombination deficiency and mismatch repair ...
Shuhei Kitamura, Ayumi Taguchi, Kana Tamai, Yoko Yamamoto, Anh Quynh Duong, Daisuke Yoshimoto, Ayako Mori, Aya Ishizaka, Saki Tsuchimochi, Kenbun Sone, Masahito Kawazu, Katsutoshi Oda, Yasushi Hirota   +12 more
wiley   +1 more source

Aspiration prevention surgeries for adult patients with brainstem malignant gliomas: illustrative cases. [PDF]

J Neurosurg Case Lessons
Ikeda K, Saito K, Sasaki N, Kobayashi K, Nagane M.   +4 more
europepmc   +1 more source