Results 31 to 40 of about 104,823 (289)

Metformin alleviates bevacizumab-induced vascular endothelial injury in mice through growth differentiation factor 15 upregulation [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Bevacizumab is a commonly used anticancer drug in clinical practice, but it often leads to adverse reactions such as vascular endothelial damage, hypertension, arterial and venous thrombosis, and bleeding.
Liqiang Chen, Yajuan Yin, Chunmiao Liu, Junying Liu, Mingqi Zheng, Yida Tang, Qing Yang, Jing Liu, Fan Chen, Lanbo Liu, Gang Liu   +10 more
doaj   +1 more source

Similar overall survival with reduced vs. standard dose bevacizumab monotherapy in progressive glioblastoma

Cancer Medicine, 2020
Introduction Bevacizumab has demonstrated activity in glioblastoma (GBM), but the true benefits and optimal dose‐schedule are debated. A lower dose‐schedule than standard‐dose bevacizumab (10 mg/kg 2‐weekly) might offer similar benefits with lower costs.
Jack Patrick Gleeson, Fergus Keane, Niamh M. Keegan, Emin Mammadov, Emily Harrold, Abdullah Alhusaini, Jeffrey Harte, Austin Eakin‐Love, Philip J. O'Halloran, Stephen MacNally, Bryan T. Hennessy, Oscar S. Breathnach, Liam Grogan, Patrick G. Morris   +13 more
doaj   +1 more source

Bevacizumab Efficiently Inhibits VEGF-Associated Cellular Processes in Equine Umbilical Vein Endothelial Cells: An In Vitro Characterization

Veterinary Sciences, 2023
Anti-VEGF agents were found to have clinical implications for the successful treatment of vascular-driven diseases in humans. In this study, a detailed biological characterization of bevacizumab in a variety of in vitro assays was carried out to ...
Ulrike Lessiak, Barbara Pratscher, Alexander Tichy, Barbara Nell   +3 more
doaj   +1 more source

Comparing the Efficacy of Bevacizumab and Ranibizumab in Patients with Retinal Vein Occlusion [PDF]

, 2020
Purpose: Comparing the efficacy of intravitreal injections of bevacizumab to ranibizumab in the treatment of macular edema (ME) resulting from retinal vein occlusion (RVO).
Verbraak, F.D. (Frank), Schauwvlieghe, AME, Hoyng, C.B., Los, LI, Jong-Hesse, Y. de, Hoyng, CB, Vader, M.J.C. (Maartje J.C.), Leeuwen, R. (Redmer) van, Vingerling, Hans, Los, L.I. (Leonoor I.), Schlingemann, RO, Leeuwen, R. Van, van Leeuwen, R, Vingerling, J.R. (Hans), Dijkgraaf, M.G., de Jong-Hesse, Y, Schlingemann, R.O. (Reinier), Dijkman, G., Zwinderman, AH, Hoyng, C.B. (Carel), Lith-Verhoeven, J.J. van, Schlingemann, R.O., van Leeuwen, R., van Lith-Verhoeven, JJC, Vingerling, J.R., Vader, MJC, Verbraak, FD, Peto, T., de Jong-Hesse, Y. (Yvonne), Dijkman, G, Dijkgraaf, M.G.W. (Marcel), Los, L.I., Hooymans, JMM, Lith-Verhoeven, J.J.C. (Janneke) van, Schauwvlieghe, A.M., Schauwvlieghe, ASME, Verbraak, F.D., Zwinderman, A.H. (Ailko), Zwinderman, A.H., de Jong-Hesse, Y., Hooymans, J.M., Peto, T. (Tünde), Hooymans, JM, Vader, M.J.C., Hooymans, J.M.M. (Johanna), Peto, T, Dijkgraaf, MG, Schauwvlieghe, A.M.E. (Ann-Sofie), Dijkgraaf, MGW   +48 more
core   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

A five arm natural history study of nasal vestibulitis

Cancer Medicine, 2023
Introduction Nasal symptoms are frequently reported by patients undergoing chemotherapy. Methods Eligible patients planning to receive paclitaxel, docetaxel, nab‐paclitaxel, bevacizumab without a concomitant taxane, or “other” (non‐taxane, non ...
Elizabeth J. Cathcart‐Rake, David Zahrieh, Deanne Smith, Susan Young, Shaylene McCue, Amanda O'Connor, Stephan Thomé, Mario Lacouture, Terra Register, Jill Piens, Bret B. Friday, Charles L. Loprinzi   +11 more
doaj   +1 more source

Bevacizumab-induced tracheoesophageal fistula in a patient suffering from lung cancer with bulky subcarinal lymph node: a case report [PDF]

, 2018
2018-02A 66-year-old male with advanced non-small-cell lung cancer (NSCLC) who was previously treated with carboplatin, pemetrexed, and bevacizumab consequently suffered from severe coughing during degluti- tion. Chest computed tomography (CT) revealed a
Yasuo, Masanori, Urushihata, Kazuhisa, Kitaguchi, Yoshiaki, Yamamoto, Hiroshi, Ideura, Gen, Nishie, Kenichi, Kobayashi, Nobumitsu, Hanaoka, Masayuki, Ushiki, Atsuhito, Tateishi, Kazunari   +9 more
core   +1 more source

Evaluation of the association between bevacizumab concentration and clinical outcomes in patients with breast cancer brain metastasis

Heliyon
Bevacizumab is widely used in various clinical indications, but investigations into its optimal dosage for treating CNS metastases remain limited. The BEEP regimen, comprising bevacizumab, etoposide, and cisplatin, has recently demonstrated promising ...
Chih-Ning Cheng, Yun-Jung Tsai, Huai-Hsuan Chiu, Tom Wei-Wu Chen, Ching-Hung Lin, Yen-Sheng Lu, Ching-Hua Kuo   +6 more
doaj   +1 more source

Intravenous Bevacizumab Therapy in a Patient with Hereditary Hemorrhagic Telangiectasia, ENG E137K, Alcoholic Cirrhosis, and Portal Hypertension

Case Reports in Gastroenterology, 2017
Intravenous bevacizumab decreased mucosal bleeding in some patients with hereditary hemorrhagic telangiectasia (HHT). We treated a 47-year-old male who had HHT, severe epistaxis, and gastrointestinal bleeding, alcoholic cirrhosis, and portal hypertension
Luigi F. Bertoli, Pauline L. Lee, Lauren Lallone, James C. Barton   +3 more
doaj   +1 more source