Results 31 to 40 of about 6,009 (196)

Targeted therapy for breast cancer prevention. [PDF]

, 2013
With a better understanding of the etiology of breast cancer, molecularly targeted drugs have been developed and are being testing for the treatment and prevention of breast cancer.
Brown, Powel H, den Hollander, Petra, Savage, Michelle I   +2 more
core   +2 more sources

Triggering of Suicidal Erythrocyte Death by Bexarotene

Cellular Physiology and Biochemistry, 2016
Background/Aims: The retinoid X receptor agonist bexarotene is utilized for the treatment of cutaneous T-cell lymphoma and is effective in several further malignancies.
Abdulla Al Mamun Bhuyan, Rosi Bissinger, Hang Cao, Florian Lang   +3 more
doaj   +1 more source

The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation In Vitro

Frontiers in Immunology, 2021
The retinoid X receptor agonist bexarotene promotes remyelination in patients with multiple sclerosis. Murine studies have also demonstrated that RXR agonists have anti-inflammatory effects by enhancing the ability of all-trans-retinoic acid (atRA) to ...
Christopher M. Gaunt, Daniel B. Rainbow, Daniel B. Rainbow, Ruairi J. Mackenzie, Lorna B. Jarvis, Hani S. Mousa, Nicholas Cunniffe, Zoya Georgieva, J. William Brown, Alasdair J. Coles, Joanne L. Jones   +10 more
doaj   +1 more source

Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations. [PDF]

, 2020
"Quantile-dependent expressivity" is a dependence of genetic effects on whether the phenotype (e.g., triglycerides) is high or low relative to its distribution in the population.
Williams, Paul T
core   +1 more source

Early Treatment Critical: Bexarotene Reduces Amyloid-Beta Burden In Silico. [PDF]

PLoS ONE, 2016
Amyloid-beta peptides have long been implicated in the pathology of Alzheimer's disease. Bexarotene, a drug approved by the U.S. Food and Drug Administration for treating a class of non-Hodgkin's lymphoma, has been reported to facilitate the removal of ...
Joseph Rosenthal, Georges Belfort, David Isaacson   +2 more
doaj   +1 more source

Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy [PDF]

, 2016
Fibrosis is a shared end-stage pathway to lung, liver, and heart failure. In the ocular mucosa (conjunctiva), fibrosis leads to blindness in trachoma, pemphigoid, and allergy.
Ahadome, SD, Calder, VL, Cousins, SW, Mathew, R, Mettu, PS, Reyes, NJ, Saban, DR   +6 more
core   +1 more source

Bexarotene-induced hypothyroidism and dyslipidemia; a nation-wide study

Endocrine Journal
Central hypothyroidism and dyslipidemia are well-known adverse events (AEs) of bexarotene therapy. Although hypothyroidism is known to cause dyslipidemia, no study has examined the association between hypothyroidism and dyslipidemia in patients ...
Katsunori Manaka, Junichiro Sato, Yusuke Hikima, Hirofumi Horikoshi, Maho Taguchi, Akimichi Morita, Hiraku Suga, Hikari Boki, Taku Fujimura, Yoji Hirai, Takatoshi Shimauchi, Chiharu Tateishi, Eiji Kiyohara, Ikko Muto, Hideki Nakajima, Riichiro Abe, Kazuyasu Fujii, Chikako Nishigori, Eiji Nakano, Kentaro Yonekura, Takeru Funakoshi, Masahiro Amano, Tomomitsu Miyagaki, Reiko Yamashita, Makoto Sugaya, Toshihisa Hamada, Masaomi Nangaku, Taroh Iiri, Noriko Makita   +28 more
doaj   +1 more source

Gene expression profiling discerns molecular pathways elicited by ligand signaling to enhance the specification of embryonic stem cells into skeletal muscle lineage

Cell & Bioscience, 2017
Regulation of lineage specification and differentiation in embryonic stem (ES) cells can be achieved through the activation of endogenous signaling, an avenue for potential application in regenerative medicine.
Katherine Dixon, Jihong Chen, Qiao Li
doaj   +1 more source

Bexarotene-Induced Hypertriglyceridemia: A Case Report

Case Reports in Oncology, 2018
We present a case of a patient with cutaneous T-cell lymphoma started on bexarotene 300 mg/m2 due to progressing disease. The patient experienced good clinical response, but unfortunately, she developed rapid and profound hypertriglyceridemia.
Chris Maminakis, Arin C. Whitman, Nahida Islam   +2 more
doaj   +1 more source

Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice [PDF]

, 2013
BACKGROUND: Though the precise cause(s) of Alzheimer’s disease (AD) remain unknown, there is strong evidence that decreased clearance of β-amyloid (Aβ) from the brain can contribute to the disease.
Alena V Savonenko, Dexter L Lee, Joanne S Allard, Juan C Troncoso, Katherine D LaClair, Kebreten F Manaye, Philip C Wong   +6 more
core   +1 more source