Results 11 to 20 of about 6,009 (196)

Brentuximab vedotin and radiotherapy for CD30-positive cutaneous T-cell lymphoma - a retrospective multicenter analysis. [PDF]

J Dtsch Dermatol Ges
Summary Background and Objectives While brentuximab vedotin (BV) and radiotherapy (RTx) are established treatment options for CD30‐positive cutaneous T‐cell lymphoma (CTCL), data on their simultaneous or sequential use regarding efficacy and tolerability remain scarce.
Schummer P, Glatzel C, Schrüfer P, Lawrenz I, Dobos G, Wehkamp U, Hüning S, Stranzenbach R, Nicolay JP, Goebeler M, Wobser M.   +10 more
europepmc   +2 more sources

Quantitative Analysis of Immune-Reactive Cells among Leukocytes Is Useful for the Diagnosis of Drug Eruptions Caused by Bexarotene

Case Reports in Oncology, 2022
Bexarotene is a third-generation retinoid X receptor-selective retinoid that has been approved for use in the treatment of cutaneous T-cell lymphomas (CTCLs). Since the objective response rate of bexarotene is relatively high, with no racial differences,
Hiromu Chiba, Yumi Kambayashi, Kentaro Ohuchi, Ryo Amagai, Erika Tamabuchi, Akira Hashimoto, Taku Fujimura   +6 more
doaj   +1 more source

Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosis

Scientific Reports, 2022
Bexarotene selectively activates retinoid X receptor, which is a commonly used anticancer agent for cutaneous T-cell lymphoma. In this study, we aimed to investigate the anticancer effect of bexarotene and its underlying mechanism in ovarian cancer in ...
Tatsuya Kobayashi, Akira Mitsuhashi, Piao Hongying, Masashi Shioya, Katsushi Kojima, Kyoko Nishikimi, Kinnosuke Yahiro, Makio Shozu   +7 more
doaj   +1 more source

Bexarotene Impairs Cognition and Produces Hypothyroidism in a Mouse Model of Down Syndrome and Alzheimer’s Disease

Frontiers in Pharmacology, 2021
All individuals with Down syndrome (DS) eventually develop Alzheimer’s disease (AD) neuropathology, including neurodegeneration, increases in β-amyloid (Aβ) expression, and aggregation and neurofibrillary tangles, between the third and fourth decade of ...
Verónica Vidal, Alba Puente, Susana García-Cerro, Susana García-Cerro, María Teresa García Unzueta, Noemí Rueda, Javier Riancho, Javier Riancho, Javier Riancho, Carmen Martínez-Cué   +9 more
doaj   +1 more source

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents [PDF]

, 2014
The NRF2 signalling cascade provides a primary response against electrophilic chemicals and oxidative stress. The activation of NRF2-signaling is anticipated to have adverse clinical consequences; NRF2 is activated in a number of cancers and ...
Campbell, Kathryn H., Henderson, Colin J., MacLeod, A. Kenneth, McLaughlin, Lesley A., McMahon, Michael, Wolf, C. Roland   +5 more
core   +8 more sources

Bexarotene improves motor function after spinal cord injury in mice

Neural Regeneration Research, 2023
[INLINE:1] Spinal cord injury is a challenge in orthopedics because it causes irreversible damage to the central nervous system. Therefore, early treatment to prevent lesion expansion is crucial for the management of patients with spinal cord injury ...
Xingyu Wang, Zhihao Shen, Haojie Zhang, Hao-Jie Zhang, Feida Li, Letian Yu, Hua Chen, Kailiang Zhou, Hui Xu, Sunren Sheng   +9 more
doaj   +1 more source

iTRAQ-derived quantitative proteomics uncovers the neuroprotective property of bexarotene in a mice model of cerebral ischemia–reperfusion injury

Saudi Pharmaceutical Journal, 2022
Bexarotene, a FDA-approved drug for cutaneous lymphoma, has been shown to exert brain protective effects. In previous study, we demonstrated that Bexarotene protects against cerebral ischemic stroke by suppressing the JNK/Caspase-3 signaling pathway ...
Hailin Liu, Hu Wang, Sisi Chen, Shengwei Liu, Xiaocui Tian, Zhi Dong, Lu Xu   +6 more
doaj   +1 more source

NRF2 regulates HER1 signaling pathway to modulate the sensitivity of ovarian cancer cells to lapatinib and erlotinib [PDF]

, 2017
NF-E2-related factor 2 (NRF2) regulates the transcription of a battery of metabolic and cytoprotective genes. NRF2 and epidermal growth factor receptors (EGFRs/HERs) are regulators of cellular proliferation and determinants of cancer initiation and ...
Bown, James L., Deeni, Yusuf Y., Hamza Kankia, Ibrahim, Khalil, Hilal S., Langdon, Simon P., Moult, Peter R.   +5 more
core   +6 more sources

Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer. [PDF]

, 2014
Preventing breast cancer is an effective strategy for reducing breast cancer deaths. The purpose of chemoprevention (also termed preventive therapy) is to reduce cancer incidence by use of natural, synthetic, or biological agents.
Brown, Powel H, Litzenburger, Beate C
core   +1 more source

Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury

Neurobiology of Disease, 2018
Traumatic brain injury (TBI) causes a high rate of mortality and disability worldwide, and there exists almost none effective drugs to protect against TBI.
Junchi He, Han Liu, Jianjun Zhong, Zongduo Guo, Jingchuan Wu, Hongrong Zhang, Zhijian Huang, Li Jiang, Hui Li, Zhaosi Zhang, Liu Liu, Yue Wu, Lingjun Qi, Xiaochuan Sun, Chongjie Cheng   +14 more
doaj   +1 more source