Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer’s disease [PDF]
Journal of Neuroinflammation, 2018 Background Alzheimer’s disease (AD) is a highly prevalent neurodegenerative disorder characterized by pathological hallmarks of beta-amyloid plaque deposits, tau pathology, inflammation, and cognitive decline. Treatment remains a clinical obstacle due to
Brad T. Casali +2 more
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Transcriptomic signature of Bexarotene (Rexinoid LGD1069) on mammary gland from three transgenic mouse mammary cancer models [PDF]
BMC Medical Genomics, 2008 Background The rexinoid bexarotene (LGD1069, Targretin) is a highly selective retinoid × receptor (RXR) agonist that inhibits the growth of pre-malignant and malignant breast cells.
Bissonnette Reid P +10 more
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Comparison of the efficacy of treatment with clobetasol propionate or bexarotene in early-stage mycosis fungoides [PDF]
Anais Brasileiros de DermatologiaBackground: There are few studies in the literature comparing the effectiveness of topical treatments in early-stage mycosis fungoides (MF). Objectives: It was aimed to evaluate the clinical efficacy, side effects and topical treatment compliance with ...
Aslı Aksu Çerman +4 more
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RXR Agonist V-125 Induces Distinct Transcriptional and Immunomodulatory Programs in Mammary Tumors of MMTV-Neu Mice Compared to Bexarotene [PDF]
BiomedicinesBackground: The retinoid X receptor (RXR) is a ligand-activated nuclear receptor that heterodimerizes with numerous partners to regulate diverse transcriptional programs.
Afrin Sultana Chowdhury +4 more
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Frontiers in Oncology, 2019 Bexarotene is a third-generation retinoid X receptor-selective retinoid that has been approved for use in the treatment of both early and advanced cutaneous T-cell lymphoma (CTCL).
Taku Fujimura +2 more
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Bexarotene ameliorated the pulmonary inflammation and M1 polarization of alveolar macrophages induced by cigarette smoke via PPARγ/HO-1 [PDF]
Respiratory ResearchBackground Alveolar macrophages (AMs) modulate pulmonary inflammation in chronic obstructive pulmonary disease (COPD), contributing to its progression. The PPARγ/RXRα heterodimer influences AM polarization induced by cigarette smoke (CS).
Haoshen Feng, Zhe Li, Rui Zheng
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Bexarotene signaling in human B and T lymphocytes induces gut-homing receptor expression [PDF]
Frontiers in ImmunologyBackgroundRetinoic acid (RA) receptors (RARs) in human lymphocytes modulate the humoral and intestinal immune response by regulating target genes, including CD38, TGM2, and gut-homing markers.
Sina Kaiser +6 more
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RXR-Mediated Remodeling of Transcriptional and Chromatin Landscapes in APP Mouse Brain: Insights from Integrated Single-Cell RNA and ATAC Profiling [PDF]
CellsLigand-activated Retinoid X Receptors (RXRs) regulate gene networks essential for neural development, neuroinflammation, and metabolism. Understanding how RXR activation influences chromatin architecture and gene expression may reveal mechanisms relevant
Yi Lu +5 more
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Pharmaceutics, 2020 Bexarotene (BEX), a specific retinoic acid X receptor (RXR) agonist granted by Food and Drug Administration (FDA) approval for the clinical treatment of T cell lymphoma, has now been found to exert pharmacological effects in the nervous system, with low ...
Shiying Yang, Jun-Ke Song, Lan Sun
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RXRα agonist bexarotene attenuates radiation-induced skin injury by relieving oxidative stress
Radiation Medicine and Protection, 2022 Objective: To investigate the protective effect of bexarotene in radiation-induced skin injury and elucidate underlying mechanism. Methods: Irradiated cellular and animal models were established using an X-ray linear accelerator.
Sheng Jiang +10 more
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