Results 1 to 10 of about 51,241 (200)

Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations [PDF]

Cells, 2019
The three subtypes (α, β, and γ) of the retinoic acid receptor (RAR) are ligand-dependent transcription factors that mediate retinoic acid signaling by forming heterodimers with the retinoid X receptor (RXR).
Albane le Maire, Catherine Teyssier, Pierre Germain   +2 more
exaly   +7 more sources

RXR-Mediated Remodeling of Transcriptional and Chromatin Landscapes in APP Mouse Brain: Insights from Integrated Single-Cell RNA and ATAC Profiling [PDF]

Cells
Ligand-activated Retinoid X Receptors (RXRs) regulate gene networks essential for neural development, neuroinflammation, and metabolism. Understanding how RXR activation influences chromatin architecture and gene expression may reveal mechanisms relevant
Yi Lu, Xuebao Wang, Carolina Saibro-Girardi, Nicholas Francis Fitz, Radosveta Koldamova, Iliya Lefterov   +5 more
doaj   +2 more sources

Cistromic insight into the association of retinoid X receptor with MyoD and CTCF in proliferating myoblasts [PDF]

Scientific Reports
In eukaryotic cells, histone acetylation and chromatin states affect gene expression programs in broad spectrum of cellular function. Comprehending the genomic signature of retinoid X receptor (RXR) will provide crucial insight into the molecular ...
Jean-Thomas Clément, Qiao Li
doaj   +2 more sources

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling. [PDF]

Glia
Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Baldassarro VA, Brassart Q, Fraulob V, Calzà L, Krezel W.   +4 more
europepmc   +2 more sources

An in silico to in vivo approach identifies retinoid-X receptor activating tert-butylphenols used in food contact materials [PDF]

Scientific Reports
The potential for food contact chemicals to disrupt genetic programs in development and metabolism raises concerns. Nuclear receptors (NRs) control many of these programs, and the retinoid-X receptor (RXR) is a DNA-binding partner for one-third of the ...
Brenda J. Mengeling, Azhagiya Singam Ettayapuram Ramaprasad, Martyn T. Smith, Dania Turkieh, Nicole C. Kleinstreuer, Kamel Mansouri, Kathleen A. Durkin, Michele A. La Merrill, J. David Furlow   +8 more
doaj   +2 more sources

Gene variants and haplotypes of Vitamin D biosynthesis, transport, and function in preeclampsia

Hypertension in Pregnancy, 2021
Objective: To find whether the gene variants and haplotypes of cytochrome (CYP) 27B1 (1α-hydroxylase), group-specific component (GC) that is a vitamin D binding protein, vitamin D receptor (VDR), peroxisome proliferator-activated receptor γ (PPARγ) and ...
Zahra Ghorbani, Mohammad Shakiba, Negin Rezavand, Ziba Rahimi, Asad Vaisi-Raygani, Zohreh Rahimi, Ebrahim Shakiba   +6 more
doaj   +1 more source

Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma. [PDF]

PLoS ONE, 2015
Genomic analysis of human hepatocellular carcinoma (HCC) is potentially confounded by the differentiation state of the hepatic cell-of-origin. Here we integrated genomic analysis of mouse HCC (with defined cell-of-origin) along with normal development ...
Jinyu Li, Maia Chanrion, Eric Sawey, Tim Wang, Edward Chow, Aaron Tward, Yi Su, Wen Xue, Robert Lucito, Lars Zender, Scott W Lowe, J Michael Bishop, Scott Powers   +12 more
doaj   +1 more source

Thyroid hormone response element half-site organization and its effect on thyroid hormone mediated transcription. [PDF]

PLoS ONE, 2014
Thyroid hormone (TH) exerts its effects by binding to the thyroid hormone receptor (TR), which binds to TH response elements (TREs) to regulate target gene expression. We investigated the relative ability of liganded homodimers TR and retinoid X receptor
Martin A Paquette, Ella Atlas, Mike G Wade, Carole L Yauk   +3 more
doaj   +1 more source

9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice. [PDF]

PLoS Genetics, 2015
The retinoid X receptors (RXRs) are ligand-activated transcription factors which heterodimerize with a number of nuclear hormone receptors, thereby controlling a variety of (patho)-physiological processes. Although synthetic RXR ligands are developed for
Ralph Rühl, Agnieszka Krzyżosiak, Anna Niewiadomska-Cimicka, Natacha Rochel, Lajos Szeles, Belén Vaz, Marta Wietrzych-Schindler, Susana Álvarez, Monika Szklenar, Laszlo Nagy, Angel R de Lera, Wojciech Krężel   +11 more
doaj   +1 more source

Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia

Biology Open, 2022
Transcriptome analyses performed in both human and zebrafish indicate strong expression of Apoe and Apoc1 by microglia. Apoe expression by microglia is well appreciated, but Apoc1 expression has not been well-examined.
Whitney A. Thiel, Emma J. Esposito, Anna P. Findley, Zachary I. Blume, Diana M. Mitchell   +4 more
doaj   +1 more source