Results 21 to 30 of about 51,241 (200)
Molecular Cancer, 2020 Background Cisplatin is a first-line drug for the treatment of human non-small cell lung cancer (NSCLC); however, the majority of patients will develop drug resistance after treatment.
Wenjing Wang +13 more
doaj +1 more source
Development of Bexarotene Analogs for Treating Cutaneous T-Cell Lymphomas
Cells, 2023 Bexarotene, a drug approved for treatment of cutaneous T-cell lymphoma (CTCL), is classified as a rexinoid by its ability to act as a retinoid X receptor (RXR) agonist with high specificity.
Ankedo Warda +12 more
doaj +1 more source
Phytochemicals as Modulators of PPARs and RXRs [PDF]
PPAR Research, 2010 Welcome to this special issue of PPAR Research on “Phytochemicals as modulators of PPARs and RXRs.” Plants have played a crucial role in the prevention and treatment of human diseases for thousands of years. A significant number of contemporary drugs with high efficacy are derived from herbal origin.
Joshua K. Ko +2 more
openaire +3 more sources
Improved convergence estimates for the Schr\"oder-Siegel problem [PDF]
, 2017 We reconsider the Schr\"oder-Siegel problem of conjugating an analytic map in $\mathbb{C}$ in the neighborhood of a fixed point to its linear part, extending it to the case of dimension $n>1$.
Giorgilli, Antonio +2 more
core +1 more source
The RAR-RXR as well as the RXR-RXR pathway is involved in signaling growth inhibition of human CD34+ erythroid progenitor cells [PDF]
Blood, 1996 Previous studies have shown that retinoic acid (RA), similar to tumor necrosis factor-alpha (TNF-alpha), can act as a bifunctional regulator of the growth of bone marrow progenitors, in that it can stimulate granulocyte-macrophage colony-stimulating factor (GM-CSF)- or interleukin-3 (IL-3)-induced GM colony formation, but potently inhibit G-CSF-induced
L S, Rusten +5 more
openaire +3 more sources
PLoS ONE, 2022 Thyroid hormone (TH) signaling plays critical roles during vertebrate development, including regulation of skeletal and cartilage growth. TH acts through its receptors (TRs), nuclear hormone receptors (NRs) that heterodimerize with Retinoid-X receptors ...
Brenda J Mengeling +2 more
doaj +2 more sources
Frontiers in Endocrinology, 2023 PurposeMolting is a pivotal biological process regulated by the ecdysteroid signaling pathway that requires molecular coordination of two transcription factors, Ecdysone receptor (EcR) and ultraspiracle (USP) in arthropods.
Xiaowen Chen +5 more
doaj +1 more source
Metabolic interactions between vitamin A and conjugated linoleic acid [PDF]
, 2014 Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner.
BANNI, SEBASTIANO +7 more
core +2 more sources
Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA
Computational and Structural Biotechnology Journal, 2023 Farnesoid X receptor (FXR) is a ligand-activated transcription factor known as bile acid receptor (BAR). FXR plays critical roles in various biological processes, including metabolism, immune inflammation, liver regeneration and liver carcinogenesis. FXR
Longying Jiang +8 more
doaj +1 more source
PPAR Research, 2011 Peroxisome proliferator-activated receptor γ (PPARγ) forms a heterodimeric DNA-binding complex with retinoid X receptors (RXRs). It has been reported that the effect of the PPAR agonist is reduced in hepatocyte RXR-deficient mice.
Atsuki Yamamoto +3 more
doaj +1 more source