Results 11 to 20 of about 51,241 (200)

Analysis of RXR/THR and RXR/PPARG2 heterodimerization by bioluminescence resonance energy transfer (BRET). [PDF]

PLoS ONE, 2013
BACKGROUND: Nuclear receptors (NR) regulate transcription of genes involved in many biological processes such as development, cell proliferation, differentiation and cell death.
Miquel Mulero, Julie Perroy, Carole Federici, Gérard Cabello, Vincent Ollendorff   +4 more
doaj   +8 more sources

RAR/RXR and PPAR/RXR Signaling in Spinal Cord Injury [PDF]

PPAR Research, 2007
The retinoid acid receptors (RAR) and peroxisome proliferator-activated receptors (PPAR) have been implicated in the regulation of inflammatory reactions. Both receptor families contain ligand-activated transcription factors which form heterodimers with retinoid X receptors (RXR). We review data that imply RAR/RXR and PPAR/RXR pathways in physiological
Jörg Mey, Sabien van Neerven
doaj   +4 more sources

RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable. [PDF]

Proceedings of the National Academy of Sciences, 1996
The RXR gamma (RXR, retinoid X receptor) gene was disrupted in the mouse. Homozygous mutant mice developed normally and were indistinguishable from their RXR gamma +/- or wild-type littermates with respect to growth, fertility, viability, and apparent behavior in the animal facility.
W, Krezel, V, Dupé, M, Mark, A, Dierich, P, Kastner, P, Chambon   +5 more
openaire   +2 more sources

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization [PDF]

ACS Chemical Neuroscience, 2017
ACS chemical neuroscience 8(9), 2065 - 2077 (2017).
Marcel Scheepstra, Sebastian A. Andrei, Rens M. J. M. de Vries, Femke A. Meijer, Jian-Nong Ma, Ethan S. Burstein, Roger Olsson, Christian Ottmann, Lech-Gustav Milroy, Luc Brunsveld   +9 more
openaire   +3 more sources

LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. [PDF]

, 2020
Developmental progression depends on temporally defined changes in gene expression mediated by transient exposure of lineage intermediates to signals in the progenitor niche.
Benner, Christopher W, Geusz, Ryan J, Harrington, Austin R, Jhala, Ulupi S, Matta, Ileana, Patel, Nisha A, Rosenfeld, Michael G, Sander, Maike, Shih, Hung-Ping, Vinckier, Nicholas K, Wang, Allen, Wang, Jianxun, Wang, Jinzhao, Wetton, Nichole, Wortham, Matthew   +14 more
core   +2 more sources

The nuclear receptors of Biomphalaria glabrata and Lottia gigantea: Implications for developing new model organisms [PDF]

, 2015
© 2015 Kaur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Antebi, A Aranda, A Bateman, A Daniel, A De Groot, A Heyland, A Le Maire, AC Chung, AE Lockyer, AE Lockyer, AE Lockyer, AE Lockyer, AE Lockyer, AE Sluder, AK Allen, AM Puinean, Anne E. Lockyer, AP Scott, AP Scott, B Stone, C Shiff, C Thummel, C Tyler, Catherine S. Jones, CB Burge, CJ Carter, CK Glass, CL Hultin, CM Adema, CM Adema, D Bouton, D Jones, D Lima, D Stange, DH Huson, DL Whitehead, E Enmark, Edwin J. Routledge, ER Levin, ES Ford, F Abascal, F Bonneton, F Ronquist, FM Sladek, G Benoit, G Escobedo, G Mitta, GN Eick, GV Markov, GV Markov, H Ueda, H Urushitani, H Zhang, H-R Koehler, I Letunic, J Auwerx, J Gutierrez-Mazariegos, J Keay, J Keay, J Oehlmann, J-M Wurtz, JT Bridgham, JT Bridgham, JW Thornton, K King-Jones, K King-Jones, K Tamura, L Chitsulo, L de F Tallarico, L-M Chen, LA Hertel, Leslie R. Noble, LFC Castro, LFC Castro, LN Rapado, M Garcia, M Kajiwara, M Knight, M Laguerre, M Pawlak, M Robinson-Rechavi, M Robinson-Rechavi, M Robinson-Rechavi, M Tillmann, M-JWA Schiffelers, MD Adams, ME Baker, ME Baker, MI Snow, N Raghavan, NE-SE-S Omran, O Simakov, P Matthiessen, P Matthiessen, P Thomas, PC Hanington, PC Hanington, PD Thomas, Peter P. Fong, PL Bardet, R Bannister, R Bannister, R Lafont, RA Velarde, RJ Greenspan, RM Sternberg, RM Sternberg, RT Yu, S Bertrand, S Kliewer, S Kumkate, S Pascoal, S Vogeler, SA Thomson, Satwant Kaur, SF Altschul, SH Golden, Susan Jobling, T Li, T Matsumoto, T Simoncini, TH Lindblom, TT Schug, W Wu, W Wu, W Wu, W Wu, X Ding, X Mu, Y Katsu, YG Jiang, ZD Zhang   +131 more
core   +7 more sources

RXR Agonists Enhance Lenalidomide Anti-Myeloma Activity and T Cell Functions while Retaining Glucose-Lowering Effect

Cells, 2023
Retinoid X receptor (RXR) heterodimerizes with the PPAR nuclear hormone receptor and regulates its downstream events. We investigated the effects of RXR agonists (LG100754, bexarotene, AGN194204, and LG101506) on lenalidomide’s anti-myeloma activity, T ...
Jian Wu, Xiaobei Wang, Min Zhang, Parker Mathews, Yubin Kang   +4 more
doaj   +1 more source

Myeloid differentiation mediated through retinoic acid receptor/retinoic X receptor (RXR) not RXR/RXR pathway [PDF]

Blood, 1994
Retinoids, such as all-trans-retinoic acid and 9-cis-retinoic acid, are naturally occurring ligands of the nuclear retinoic acid receptors (RARs). In concert with binding of ligand, these receptors from heterodimers with the retinoic X receptor (RXR) and transactivate RAR/RXR-responsive genes.
M I, Dawson, E, Elstner, M, Kizaki, D L, Chen, S, Pakkala, B, Kerner, H P, Koeffler   +6 more
openaire   +3 more sources

Electronic depth profiles with atomic layer resolution from resonant soft x-ray reflectivity [PDF]

, 2015
The analysis of x-ray reflectivity data from artificial heterostructures usually relies on the homogeneity of optical properties of the constituent materials.
Alff, L., Büchner, B., Geck, J., Hamann-Borrero, J. E., He, F., Komissinskiy, P., Macke, S., Sawatzky, G. A., Sutarto, R., Vafaee, M., Zwiebler, M.   +10 more
core   +2 more sources

Of Retinoids and Organotins: The Evolution of the Retinoid X Receptor in Metazoa

Biomolecules, 2020
Nuclear receptors (NRs) are transcription factors accomplishing a multiplicity of functions, essential for organismal homeostasis. Among their numerous members, the retinoid X receptor (RXR) is a central player of the endocrine system, with a singular ...
Elza Fonseca, Raquel Ruivo, Débora Borges, João N. Franco, Miguel M. Santos, L. Filipe C. Castro   +5 more
doaj   +1 more source