Results 31 to 40 of about 51,241 (200)
Retinoic acid as a modulator of T cell immunity [PDF]
, 2016 Indexación: Scopus. DOAJ.Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual system,
Bono, M.R. +5 more
core +1 more source
Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells [PDF]
Genes & Development, 2003 The retinoid X receptor (RXR) is essential as a common heterodimerization partner of several nuclear receptors (NRs). However, its function as a bona fide receptor for endogenous ligands has remained poorly understood. Such a role would depend on the existence of RXR activating ligands in vivo and on the ability of such ligands to influence relevant ...
Asa, Wallen-Mackenzie +10 more
openaire +2 more sources
Novel Roles of Retinoid X Receptor (RXR) and RXR Ligand in Dynamically Modulating the Activity of the Thyroid Hormone Receptor/RXR Heterodimer [PDF]
Journal of Biological Chemistry, 2004 Many members of the type II nuclear receptor subfamily function as heterodimers with the retinoid X receptor (RXR). A permissive heterodimer (e.g. peroxisome proliferator-activated receptor/RXR) allows for ligand binding by both partners of the receptor complex.
Dangsheng, Li +4 more
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PPARs, RXRs, and Drug‐Metabolizing Enzymes [PDF]
PPAR Research, 2009 This special issue of PPAR Research is dedicated to “PPARs, RXRs and Drug Metabolizing Enzymes”. Knowledge of PPAR biology, over the past five years, has dramatically increased our understanding of the potential therapeutic usefulness of these receptors in metabolic alterations associated with disease process of alcoholic and non-alcoholic fatty liver ...
James P. Hardwick, John Y. L. Chiang
openaire +3 more sources
Cross-Talk between PPARs and the Partners of RXR: A Molecular Perspective
PPAR Research, 2009 The PPARs are integral parts of the RXR-dependent signaling networks. Many other nuclear receptor subfamily 1 members also require RXR as their obligatory heterodimerization partner and they are often co-expressed in any given tissue.
Lap Shu Alan Chan, Richard A. Wells
doaj +1 more source
RXR-dependent and RXR-independent transactivation by retinoic acid receptors
Nucleic Acids Research, 1993 The binding affinity of retinoic acid receptors (RARs) to their response elements is strongly enhanced in vitro by the formation of heterodimers with retinoid X receptors (RXRs) suggesting that heterodimerization with RXR may be a prerequisite for a RAR-mediated transcriptional response.
Schräder M +5 more
openaire +4 more sources
Molecular Recognition of Agonist Ligands by RXRs [PDF]
Molecular Endocrinology, 2002 The nuclear receptor RXR is an obligate partner in many signal transduction pathways. We report the high-resolution structures of two complexes of the human RXRalpha ligand-binding domain specifically bound to two different and chemically unrelated agonist compounds: docosa hexaenoic acid, a natural derivative of eicosanoic acid, present in mammalian ...
Egea, PF, Mitschler, A, Moras, D
openaire +5 more sources
Expression proteomics predicts loss of RXR-γ during progression of epithelial ovarian cancer. [PDF]
PLoS ONE, 2013 The process of cellular transformation involves cascades of molecular changes that are modulated through altered epigenetic, transcription, post-translational and protein regulatory networks.
Rajkumar S Kalra, Sharmila A Bapat
doaj +1 more source
Critical points and resonance of hyperplane arrangements [PDF]
, 2009 If F is a master function corresponding to a hyperplane arrangement A and a collection of weights y, we investigate the relationship between the critical set of F, the variety defined by the vanishing of the one-form w = d log F, and the resonance of y ...
A. Varchenko +31 more
core +5 more sources
Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis [PDF]
, 2017 Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being ...
Adamo +23 more
core +4 more sources