Results 101 to 110 of about 4,208,806 (276)

Beyond the Standard Model in Many Directions

open access: yes, 2004
These four lectures constitute a gentle introduction to what may lie beyond the standard model of quarks and leptons interacting through $SU(3)_c \otimes SU(2)_L \otimes U(1)_Y$ gauge bosons, prepared for an audience of graduate students in experimental ...
Quigg, Chris
core   +3 more sources

Masses Beyond the Standard Model

open access: yes, 1997
If we are to understand the pattern of fermion masses and mixing angles it is necessary to go beyond the Standard Model. One obvious possibility is that there is further structure, Grand Unification, strings etc., at a high scale which determines the Yukawa couplings responsible for the masses.
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Detecting dark matter with Aharonov-Bohm

open access: yesJournal of High Energy Physics, 2019
While the evidence for dark matter continues to grow, the nature of dark matter remains a mystery. A dark U(1) D gauge theory can have a small kinetic mixing with the visible photon which provides a portal to the dark sector.
John Terning, Christopher B. Verhaaren
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Baryogenesis, dark matter, and flavor structure in non-thermal moduli cosmology

open access: yesJournal of High Energy Physics, 2019
The appearance of scalar/moduli fields in the early universe, as motivated by string theory, naturally leads to non-thermal “moduli cosmology”. Such cosmology provides a consistent framework where the generation of radiation, baryons, and dark matter can
Mu-Chun Chen, Volodymyr Takhistov
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Impact of vacuum stability constraints on the phenomenology of supersymmetric models

open access: yesJournal of High Energy Physics, 2019
We present a fast and efficient method for studying vacuum stability constraints in multi-scalar theories beyond the Standard Model. This method is designed for a reliable use in large scale parameter scans.
Wolfgang G. Hollik   +2 more
doaj   +1 more source

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