Results 101 to 110 of about 1,076,028 (306)

restrepo/beyond-the-standard-model untagged-43ac5021cf1c4cf698da

, 2018
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longas14, rescolo, Diego Restrepo
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Beyond the Standard Model’ 17

, 2018
We discuss the status of the Standard Model (SM): the principles; the Lagrangian; the problems; open questions and the ways beyond. Then we consider possible physics beyond the SM: New symmetries (Gauge, SUSY); New particles (gauge, axion, superpartners); New dimensions (extra, large, compact, etc) or a New Paradigm (strings, branes, gravity).
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

restrepo/beyond-the-standard-model untagged-1443efbc9349b590e6c6

, 2017
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longas14, rescolo, Diego Restrepo
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Saxion cosmology for thermalized gravitino dark matter

Journal of High Energy Physics, 2017
In all supersymmetric theories, gravitinos, with mass suppressed by the Planck scale, are an obvious candidate for dark matter; but if gravitinos ever reached thermal equilibrium, such dark matter is apparently either too abundant or too hot, and is ...
Raymond T. Co, Francesco D’Eramo, Lawrence J. Hall, Keisuke Harigaya   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Lattice gauge theory for physics beyond the Standard Model [PDF]

, 2019
This document is one of a series of white papers from the USQCD Collaboration. Here, we discuss opportunities for lattice field theory research to make an impact on models of new physics beyond the Standard Model, including composite Higgs, composite ...
Fleming, G, Giedt, Joel, Schaich, D, Hasenfratz, Anna, Brower, Richard C., Schaich, David, Neil, Ethan T., Weinberg, Evan, Brower, RC, Weinberg, E, Rinaldi, Enrico, Giedt, J, Catterall, Simon, Hasenfratz, A, Witzel, Oliver, Fleming, George, Rinaldi, E, Neil, ET, Witzel, O, Catterall, S   +19 more
core   +1 more source