Results 131 to 140 of about 2,336,278 (343)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Journal of High Energy Physics, 2017 It is well known that the annihilation of Majorana dark matter into fermions is helicity suppressed. Here, we point out that the underlying mechanism is a subtle combination of two distinct effects, and we present a comprehensive analysis of how the ...
Torsten Bringmann +3 more
doaj +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Starobinsky-like inflation and soft-SUSY breaking
Journal of High Energy Physics, 2019 We study a version of Starobinsky-like inflation in no-scale supergravity (SUGRA) where a Polonyi term in the hidden sector breaks supersymmetry (SUSY) after inflation, providing a link between the gravitino mass and inflation.
Stephen F. King, Elena Perdomo
doaj +1 more source
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
Robustness of dark matter constraints and interplay with collider searches for New Physics
Journal of High Energy Physics, 2017 We study the implications of dark matter searches, together with collider constraints, on the phenomenological MSSM with neutralino dark matter and focus on the consequences of the related uncertainties in some detail. We consider, inter alia, the latest
A. Arbey +3 more
doaj +1 more source
Search for physics beyond the standard model [PDF]
, 1994 V. Barger, R. J. N. Phillips
openalex +1 more source
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
Dark matter casts light on the early Universe
Journal of High Energy Physics, 2018 We show how knowledge of the cold dark matter (CDM) density can be used, in conjunction with measurements of the parameters of a scenario for beyond the Standard Model (BSM) physics, to provide information about the evolution of the Universe before Big ...
A. Arbey +3 more
doaj +1 more source