Results 131 to 140 of about 5,577,820 (369)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Saxion cosmology for thermalized gravitino dark matter

Journal of High Energy Physics, 2017
In all supersymmetric theories, gravitinos, with mass suppressed by the Planck scale, are an obvious candidate for dark matter; but if gravitinos ever reached thermal equilibrium, such dark matter is apparently either too abundant or too hot, and is ...
Raymond T. Co, Francesco D’Eramo, Lawrence J. Hall, Keisuke Harigaya   +3 more
doaj   +1 more source

Almost-Commutative Geometries Beyond the Standard Model

, 2005
In [7-9] and [10] the conjecture is presented that almost-commutative geometries, with respect to sensible physical constraints, allow only the standard model of particle physics and electro-strong models as Yang-Mills-Higgs theories. In this publication
Christoph A Stephan, Connes A, Connes A, Fargion D Khlopov M Stephan C A, Gracia-Bondia J M, Jureit J-H Stephan C A, Knecht M Schücker T, Schücker T, Schücker T   +8 more
core   +1 more source

Masses Beyond the Standard Model

, 1997
If we are to understand the pattern of fermion masses and mixing angles it is necessary to go beyond the Standard Model. One obvious possibility is that there is further structure, Grand Unification, strings etc., at a high scale which determines the Yukawa couplings responsible for the masses.
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Beyond the Standard Model with HAWC [PDF]

, 2023
P. Harding, A. Albert, Ruben Jose Alfaro, César Álvarez, Alexis Andres, Juan Carlos Arteaga Velázquez, D. Avila Rojas, H. A. Ayala Solares, Rishi Babu, Ernesto Belmont-Moreno, T. Capistrán, Sohyoun Yun, A. Carramiñana, Fernanda Carreon-Gonzalez, U. Cotti, J. Cotzomi, S. Coutiño de León, E. De la Fuente, Davide Depaoli, Cederik León de León, R. Díaz Hernández, J. C. Díaz–Vélez, Brenda Dingus, Mora Durocher, M. A. DuVernois, K. Engel, María Catalina Espinoza Hernández, Kwok Lung Fan, Ke Fang, N. Fraija, J. A. García-González, F. Garfias, Hazal Goksu, M. M. González, J. A. Goodman, Sam J Groetsch, J. P. Harding, Sergio Hernández Cadena, Ian Herzog, J. A. Hinton, B. Hona, Dezhi Huang, F. Hueyotl‐Zahuantitla, P. Hüntemeyer, A. Iriarte, Vikas Joshi, S. Kaufmann, D. Kieda, A. Lara, J. S. H. Lee, William H. Lee, H. León Vargas, J. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, J. Martínez-Castro, J. Matthews, P. Miranda-Romagnoli, Jorge Alexis Montes, Jorge Antonio Morales Soto, M. Mostafá, L. Nellen, M. U. Nisa, R. Noriega-Papaqui, Laura Olivera-Nieto, N. Omodei, Y. Pérez Araujo, Eucario Gonzalo Pérez Pérez, Alvaro Pratts, Chang Dong Rho, D. Rosa‐González, E. Ruiz-Velasco, Humberto Ibarguen Salazar, Daniel Salazar-Gallegos, A. Sandoval, M. Schneider, Georg Schwefer, José Serna-Franco, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, Kirsten Tollefson, I. Torres, Ramiro Torres Escobedo, Rhiannon M. Turner, F. Ureña-Mena, Enrique Varela, L. Villaseñor, Xiaojie Wang, I. J. Watson, Felix Werner, Kara M. Whitaker, Elijah Job Willox, Hongyi Hongyi Wu, H. Zhou, K. S. Caballero‐Mora   +97 more
openalex   +1 more source

Beyond Standard Model Higgs

, 2014
Recent LHC highlights of searches for Higgs bosons beyond the Standard Model are presented. The results by the ATLAS and CMS collaborations are based on 2011 and 2012 proton-proton collision data at centre-of-mass energies of 7 and 8 TeV, respectively ...
Lange, Clemens
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Higgs: Standard Model and Beyond

, 2002
In this talk, I will discuss possible new physics effects that modify the interaction of Higgs boson(s) with top and bottom quarks, and discuss how to detect such effects in current and future high energy colliders.Comment: LaTeX, 8 pages including 1 ...
Yuan, C. -P.
core   +2 more sources

Beyond the Standard Model at HERA

, 2007
The prospects of physics beyond the standard model in deep inelastic scattering are reviewed, emphasizing the search for contact interactions, for leptoquarks and for supersymmetry with R-parity violation. R-parity violating supersymmetry is explored as a speculative source of events with high energy muons and missing transverse momentum, but no ...
openaire   +3 more sources