PRMT5 binds and methylates EphA2, which stabilizes EphA2 via inhibiting Cbl‐mediated EphA2 ubiquitination degradation to promote NPC stemness. PRMT5‐derived peptide P20 disrupts PRMT5–EphA2 interaction, which degrades EphA2 via enhancing Cbl‐mediated EphA2 ubiquitination degradation to suppress NPC stemness.
Zheng‐Zheng Yu +16 more
wiley +1 more source
Therapeutic efficacy of genetically engineered neural stem cells in cerebral ischemia: a systematic review and meta-analysis. [PDF]
Li S +6 more
europepmc +1 more source
Uncoupling TGFβ1 signalling from collagen protein synthesis in Dupuytren's disease
Abstract Dupuytren's disease is a fibroproliferative disorder of the palmer fascia (PF) characterised by flexion contractures in the hand. Dupuytren's disease can be treated surgically, but disease recurrence rates are high, potentially due to continual production of matrisomal proteins.
Gabriella Cooper +12 more
wiley +1 more source
Dehydroascorbic Acid Induces Cell Death in Sarcoma Stem Cells Under bFGF-Mediated Stemness-Supporting Conditions. [PDF]
Ledinski M +6 more
europepmc +1 more source
Research Progress on Platelet‐Rich Plasma (PRP) in the Treatment of Androgenetic Alopecia
ABSTRACT Background Androgenetic alopecia (AGA) is the most common cause of progressive hair loss, significantly affecting quality of life. Current therapies, such as minoxidil, finasteride, and hair transplantation, show variable efficacy and may be associated with adverse effects.
Zetian Zhong +4 more
wiley +1 more source
Basic Fibroblast Growth Factor, bFGF
openaire +2 more sources
Immunophenotypic characterization of canine oligodendroglioma cells cultured in an oligodendrocyte precursor cell-tailored medium. [PDF]
Yoshida K +3 more
europepmc +1 more source
Targeting Arterial Dysfunction in Cardiovascular Disease Using Stem Cell‐Based Therapies
Graphical presentation of stem cell‐based therapies for arterial dysfunction, endothelial repair and regeneration strategies. SMC, smooth muscle cell. ABSTRACT Arterial regeneration represents a critical frontier in cardiovascular medicine, as progressive endothelial dysfunction, maladaptive vascular smooth muscle cell (SMC) plasticity, and chronic ...
Yun‐Yu Ma, Shu‐Yao Zhu, Yi Song
wiley +1 more source
pH-responsive bilayer hydrogel with sequential release of morin-based nanoparticles and bFGF for the treatment of the "ice and fire" wounds. [PDF]
Yi M +12 more
europepmc +1 more source
Basic Fibroblast Growth Factor-Releasing Bioabsorbable Polyglycolic Acid Dura Mater Enhances Neural Progenitor Cell Proliferation and Neuroprotection After Brain Injury. [PDF]
Ito Y, Oyane A, Matsumaru Y, Ishikawa E.
europepmc +1 more source

