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Effects of a Synthetic bFGF Antagonist Peptide on the Proteome of 3T3 Cells Stimulated with bFGF
International Journal of Peptide Research and Therapeutics, 2011It has been known that basic fibroblast growth factor (bFGF) plays an important role in tumor progression mainly due to its strong mitogenic activity. Antagonists targeting bFGF have been considered a potential strategy for cancer therapy via inhibiting cell proliferation induced by bFGF. We have previously obtained a high-affinity bFGF-binding peptide
Xiaoping Wu +7 more
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2010
Hypertrophic scars or keloid scars caused by burns are sometimes problematic when functional regions such as articular joints or conspicuous areas on the face or extremities are involved [1]. Massive burn wound scars have a tendency to develop progressive hypertrophic scars, and earlier skin grafting may improve the overall skin quality as well as ...
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Hypertrophic scars or keloid scars caused by burns are sometimes problematic when functional regions such as articular joints or conspicuous areas on the face or extremities are involved [1]. Massive burn wound scars have a tendency to develop progressive hypertrophic scars, and earlier skin grafting may improve the overall skin quality as well as ...
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Inhibitory effect of bFGF on endochondral heterotopic ossification
Biochemical and Biophysical Research Communications, 2002Basic fibroblast growth factor (bFGF) is reported to stimulate repair of fracture and bony defects in in vivo animal studies. However, most studies performed in vitro demonstrate inhibitory effect of bFGF on cartilage and bone differentiation. To understand the discrepancy observed in in vivo and in vitro studies, we evaluated the effect of bFGF on ...
Shinji, Sakano +7 more
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Serum bFGF concentrations in gastric cancer patients.
Bratislavske lekarske listy, 2008Angiogenetic factors play an important role in the formation of new blood vessels involved in the growth and metastatic spread of solid tumors, but there is limited information regarding the clinical significance of serum bFGF levels in gastric cancer patients.Serum bFGF concentrations were measured by quantitative sandwich enzyme immunoassay technique
Bilgic, I, Ozalp, N., Tez, M., Koc, M.
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Centrosome reorientation in regenerating endothelial monolayers requires bFGF
Journal of Cellular Biochemistry, 1993AbstractMonolayers of endothelial cells respond to physical denudation with a characteristic sequence of lamellipodia extrusion, cell migration, and cell proliferation. Basic fibroblast growth factor (bFGF) has been implicated as a necessary component of this process: addition of exogenous bFGF enhances monolayer regeneration both in vitro and in vivo,
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