Results 41 to 50 of about 85,696 (286)

Comparison of the protective effects of truncated bFGF and native bFGF against murine lung carcinoma

International Journal of Molecular Medicine, 2011
Basic fibroblast growth factor (bFGF), an angiogenic factor, exhibits pro-angiogenic abilities by interacting with tyrosine kinase receptors and heparin-sulfated proteoglycan receptors. Here, we designed an N-, C-terminally truncated basic fibroblast growth factor (tbFGF) for immuno-therapy of murine lung carcinoma with PCEC hydrogel as adjuvant ...
Zichao, Luo, Xinyun, Peng, Huashan, Shi, Changyang, Gong, Zhiyong, Qian, Li, Yang   +5 more
openaire   +3 more sources

Treatment of adhesions after Achilles tendon injury using focused ultrasound with targeted bFGF plasmid-loaded cationic microbubbles

Open Chemistry, 2020
Nonviral targeting technology has become promising as a form of gene therapy for diseases and injuries, such as Achilles tendon injuries. In this study, we used avidin–biotin bridge and positive–negative charge attractions to load the intercellular ...
Shen Yuzhou, Ma Jiancheng, Jiang Junsheng, Chen Zhilin, Yan Wenzhu, Wang Yue, Wang Feng, Liu Li   +7 more
doaj   +1 more source

Frondoside A suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis [PDF]

, 2013
A major challenge for oncologists and pharmacologists is to develop less toxic drugs that will improve the survival of lung cancer patients. Frondoside A is a triterpenoid glycoside isolated from the sea cucumber, Cucumaria frondosa and was shown to be a
Adrian, Thomas E, Al Sultan, Mahmood Ahmed, Arafat, Kholoud, Attoub, Samir, Bracke, Marc, Collin, Peter, De Wever, Olivier, Gelaude, An, Takahashi, Takashi   +8 more
core   +3 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Perivascular mast cells regulate vein graft neointimal formation and remodeling [PDF]

, 2015
Objective. Emerging evidence suggests an important role for mast cells in vein graft failure. This study addressed the hypothesis that perivascular mast cells regulate in situ vascular inflammatory and proliferative responses and subsequent vein graft ...
Cambrook, Helen, Carberry, Jaclyn, Grassia, Gianluca, Ialenti, Armando, Kennedy, Simon, Lawrence, Catherine, MacRitchie, Neil, Maffia, Pasquale, Wadsworth, Roger M., Wu, Junxi   +9 more
core   +3 more sources

The Stability of bFGF Against Thermal Denaturation

Journal of Pharmacy and Pharmacology, 1994
Abstract The influence of sulphated ligand and pH on thermal denaturation of basic fibroblast growth factor (bFGF) was investigated by differential scanning calorimetry (DSC), and verified by fluorescence spectrophotometry. Purity of bFGF before and after heat denaturation was assessed by SDS-PAGE analysis.
S, Vemuri, I, Beylin, V, Sluzky, P, Stratton, G, Eberlein, Y J, Wang   +5 more
openaire   +2 more sources

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, EarlyView.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. [PDF]

, 2003
Antagonists of alphavbeta3 and alphavbeta5 disrupt angiogenesis in response to bFGF and VEGF, respectively. Here, we show that these alphav integrins differentially contribute to sustained Ras-extracellular signal-related kinase (Ras-ERK) signaling in ...
Cheresh, David A, Frausto, Ricardo, Hood, John D, Kiosses, William B, Schwartz, Martin A   +4 more
core   +1 more source

Basic fibroblast growth factor modulates cell cycle of human umbilical cord-derived mesenchymal stem cells. [PDF]

, 2012
Background: Mesenchymal stem cells (MSC) have great potential in regenerative medicine, immunotherapy and gene therapy due to their unique properties of self-renewal, high plasticity, immune modulation and ease for genetic modification.
Ramasamy, Rajesh, Seow, Heng Fong, Tan, B. C., Tong, C. K., Vellasamy, S., Yip, W. K.   +5 more
core   +1 more source

Effect of basic fibroblast growth factor with collagen/gelatin fixture in a rabbit model of nasal septum perforation

Regenerative Therapy
Introduction: The treatment of nasal septum perforation solely by surgical intervention presents significant challenges. This study evaluated the effect of basic fibroblast growth factor (bFGF) in combination with collagen/gelatin on wound healing of ...
Yuki Takizawa, Tsunetaro Morino, Ryo Takagi, Nobuyoshi Otori, Hiromi Kojima, Masayuki Yamato   +5 more
doaj   +1 more source