Results 71 to 80 of about 1,254 (114)

bFGF influences human articular chondrocyte differentiation

Cytotherapy, 2007
The possible functional role of basic fibroblast growth factor (bFGF) in regulating the mitotic and metabolic activity of primary human articular chondrocytes was investigated.[EF1]Chondrocytes were enzymatically isolated from femoral head cartilage, and were cultured in vitro in monolayer. bFGF-dependent cell proliferation, production of collagen type
Schmal, Hagen, Zwingmann, Jörn, Fehrenbach, M., Finkenzeller, Günter, Stark, Gerhard Björn, Südkamp, Norbert P., Hartl, Dominik, Mehlhorn, Alexander   +7 more
openaire   +3 more sources

Wound dressings containing bFGF-impregnated microspheres

Journal of Microencapsulation, 2006
The primary objective was to synthesize a novel wound dressing containing basic fibroblast growth factor (bFGF)-loaded microspheres for promoting healing and tissue regeneration. Gelatin sponge was chosen as the underlying layer and elastomeric polyurethane membranes were used as the external layer.
Sha, Huang, Tianzheng, Deng, Hong, Wu, Faming, Chen, Yan, Jin   +4 more
openaire   +2 more sources

A unique bFGF-responsive transcriptional element

Gene, 1999
The mitogen-regulated protein/proliferin (mrp/plf) genes encode closely related proteins that stimulate cell proliferation and angiogenesis. Basic fibroblast growth factor (bFGF) increases mrp/plf mRNA and protein production by 3T3 cells. Although the three cloned mrp/plf gene promoters are over 97% identical, only mrp3 is transcriptionally activated ...
M A, Mohideen, A, Hruska-Hageman, M, Nilsen-Hamilton   +2 more
openaire   +2 more sources

Basic fibroblast growth factor (bFGF) receptors decrease with luteal age in rat ovarian luteal cells: colocalization of bFGF receptors and bFGF in luteal cells

Endocrinology, 1993
Ovarian growth factors have been implicated in the development and differentiation of corpus luteum. We have characterized both high and low affinity receptors for basic fibroblast growth factor (bFGF) in luteal cells and tissue throughout the life span of corpus luteum using gonadotropin-treated rat luteinized ovaries. Additionally, we determined bFGF
R, Asakai, K, Tamura, Y, Eishi, M, Iwamoto, Y, Kato, R, Okamoto   +5 more
openaire   +3 more sources

Immunolocalization of bFGF in Pterygia

Cornea, 1997
To examine the expression of basic fibroblast growth factor in pterygia and determine whether mast cells contain basic fibroblast growth factor (bFGF) in this disease process.Formalin-fixed paraffin-embedded tissue samples of pterygia (n = 14) were used to study the expression of bFGF with immunohistochemistry.
M R, Powers, Z, Qu, B, O'Brien, D J, Wilson, J E, Thompson, J T, Rosenbaum   +5 more
openaire   +2 more sources

Endothelial proteoglycans inhibit bFGF binding and mitogenesis

Journal of Cellular Physiology, 1997
Basic fibroblast growth factor (bFGF) is a known mitogen for vascular smooth muscle cells and has been implicated as having a role in a number of proliferative vascular disorders. Binding of bFGF to heparin or heparan sulfate has been demonstrated to both stimulate and inhibit growth factor activity.
K E, Forsten, N A, Courant, M A, Nugent
openaire   +2 more sources

bFGF Redox Signaling in Hypopharyngeal Cancer

Otolaryngology–Head and Neck Surgery, 2012
ObjectiveExamine the role of basic fibroblast growth factor (bFGF) in the generation of reactive oxygen species (ROS) in FaDu pharyngeal carcinoma cell lines. Evaluate the consequences of disrupting bFGF mediated signaling in tumor cells.MethodBasic science study of hypopharyngeal carcinoma from 2010 to 2012.
Brendan G. Fennessy, John F. Woolley, Thomas G. Cotter   +2 more
openaire   +1 more source

Bone ingrowth in bFGF-coated hydroxyapatite ceramic implants

Biomaterials, 2003
This experimental study was performed to evaluate angiogenesis, bone formation, and bone ingrowth in response to osteoinductive implants of bovine-derived hydroxyapatite (HA) ceramics either uncoated or coated with basic fibroblast growth factor (bFGF) in miniature pigs.
Reinhard, Schnettler, Volker, Alt, Elvira, Dingeldein, Hans-Joachim, Pfefferle, Olaf, Kilian, Christof, Meyer, Christian, Heiss, Sabine, Wenisch   +7 more
openaire   +2 more sources

The effects of bFGF on RCS rat eyes

Current Eye Research, 1995
Basic fibroblast growth factor (bFGF) has been implicated as a factor in retinal differentiation and disease. Recent studies have shown that subretinal or intravitreal injections of bFGF delay the retinal degeneration of the RCS rat but the global nature of this effect has been quantified for few test animals and the mechanism underlying this effect is
J, Perry, J, Du, H, Kjeldbye, P, Gouras
openaire   +2 more sources

Effects of a Synthetic bFGF Antagonist Peptide on the Proteome of 3T3 Cells Stimulated with bFGF

International Journal of Peptide Research and Therapeutics, 2011
It has been known that basic fibroblast growth factor (bFGF) plays an important role in tumor progression mainly due to its strong mitogenic activity. Antagonists targeting bFGF have been considered a potential strategy for cancer therapy via inhibiting cell proliferation induced by bFGF. We have previously obtained a high-affinity bFGF-binding peptide
Xiaoping Wu, Xinglong Jia, Yuhua Ji, Cong Wang, Yonglin Yu, Susu Gao, Quchou Li, Xiaokun Li   +7 more
openaire   +1 more source