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Hey bHLH Transcription Factors
2014Hey bHLH transcription factors are direct targets of canonical Notch signaling. The three mammalian Hey proteins are closely related to Hes proteins and they primarily repress target genes by either directly binding to core promoters or by inhibiting other transcriptional activators.
David, Weber +2 more
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Hey bHLH Factors in Cardiovascular Development
Pediatric Cardiology, 2009The Notch pathway is now firmly established as a key signaling system for embryonic cardiovascular development as well as some adult pathologies in vertebrates. We have identified Hey bHLH transcriptional repressors as critical, but partly redundant transducers of these signals.
Cornelia, Wiese +2 more
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Gene, 1996
Gene duplication is thought to be a major genetic change that may have permitted the evolution of vertebrates from invertebrates. The myogenic genes encode basic helix-loop-helix (bHLH) transcriptional factors essential for the formation of skeletal muscle. The invertebrate genome contains only a single myogenic bHLH gene, whereas the vertebrate genome
I, Araki, K, Terazawa, N, Satoh
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Gene duplication is thought to be a major genetic change that may have permitted the evolution of vertebrates from invertebrates. The myogenic genes encode basic helix-loop-helix (bHLH) transcriptional factors essential for the formation of skeletal muscle. The invertebrate genome contains only a single myogenic bHLH gene, whereas the vertebrate genome
I, Araki, K, Terazawa, N, Satoh
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bHLH Transcription factors and mammalian neuronal differentiation
The International Journal of Biochemistry & Cell Biology, 1997The basic helix-loop-helix (bHLH) factor Mash1 is expressed in the developing nervous system. Null mutation of Mash1 results in loss of olfactory and autonomic neurons and delays differentiation of retinal neurons, indicating that Mash1 promotes neuronal differentiation.
R, Kageyama +3 more
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1998
Abstract As described in Chapter 3, the basic helix-loop-helix (bHLH) proteins are a large superfamily of dimeric transcription factors in which the HLH motif mediates protein dimerization and the basic domain mediates DNA binding. In some bHLH families, such as the myogenic bHLH family consisting of MYOD, MYOGENIN, MYFS, and MRF4 ...
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Abstract As described in Chapter 3, the basic helix-loop-helix (bHLH) proteins are a large superfamily of dimeric transcription factors in which the HLH motif mediates protein dimerization and the basic domain mediates DNA binding. In some bHLH families, such as the myogenic bHLH family consisting of MYOD, MYOGENIN, MYFS, and MRF4 ...
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bHLH Proteins and Their Role in Somitogenesis
2008The most obvious manifestation of the existence of a segmented, or metameric, body plan in vertebrate embryos is seen during the formation of the somites. Somites are transient embryonic structures formed in a progressive manner from a nonsegmented mesoderm in a highly regulated process called somitogenesis.
Maroto, Miguel +3 more
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The functions of bHLH proteins
1998Abstract Most known bHLH proteins are transcriptional regulators. That is, they are proteins that are able to alter the genetic programme of cells by repressing or activating specific genes, often genes involved in control of growth and differentiation. Not surprisingly, therefore, inappropriate expression of genes encoding both bHLH and
Trevor D Littlewood, Gerard I Evan
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Proneural bHLH Genes in Development and Disease
2014Proneural genes encode evolutionarily conserved basic-helix-loop-helix transcription factors. In Drosophila, proneural genes are required and sufficient to confer a neural identity onto naïve ectodermal cells, inducing delamination and subsequent neuronal differentiation. In vertebrates, proneural genes are expressed in cells that already have a neural
Carol, Huang +2 more
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Asymmetric DNA Binding by A Homodimeric bHLH Protein
Biochemistry, 2000Protein-DNA interactions that lie outside of the core recognition sequence for the Drosophila bHLH transcription factor Deadpan (Dpn) were investigated using minor groove binding pyrrole-imidazole polyamides. Electrophoretic mobility shift assays and DNase I footprinting demonstrate that hairpin polyamides bound immediately upstream, but not ...
Winston, Rachel L. +4 more
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Characterization of hey bHLH genes in teleost fish
Development Genes and Evolution, 2003Hairy-related basic helix-loop-helix (bHLH) transcription factors are targets of Delta-Notch signaling and represent essential components for a number of cell fate decisions during vertebrate embryogenesis. Hey genes encode a subfamily of hairy-related proteins that have been implicated in processes like somitogenesis, blood vessel and heart ...
Christoph, Winkler +4 more
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