Results 41 to 50 of about 1,417,946 (293)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Metalliferous jurassic rocks of the Fan-Y agnob syneclise (Central Tajikistan)
Известия высших учебных заведений: Геология и разведкаBackground. The Fan-Yagnob syneclise is an imposed structure within the Hercynian Zeravshan-Gissar zone. It formed on a Paleozoic folded basement as series of sedimentary rocks from T3 to N1, including Jurassic, Cretaceous, and Paleogene terrigenous ...
M. Saymudasiri, A. K. Litvinenko
doaj +1 more source
FEATURES IN THE DEVELOPMENT OF INFORMATION SYSTEMS TO SMALL BUSINESSES
Российский технологический журнал, 2016 The development of information systems for small enterprises despite the objective difficulties and reduced budgets for IT infrastructure requires an in-depth strategic approach.
K. Shishmanov
doaj +1 more source
Scientific Reports, 2021 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Jorgen Randers, Ulrich Goluke
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
A user-friendly earth system model of low complexity: the ESCIMO system dynamics model of global warming towards 2100 [PDF]
Earth System Dynamics, 2016 We have made a simple system dynamics model, ESCIMO (Earth System Climate Interpretable Model), which runs on a desktop computer in seconds and is able to reproduce the main output from more complex climate models.
J. Randers +3 more
doaj +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Limits of a Second Language: Native and Second Languages in Management Team Communication
Frontiers in Psychology, 2021 Cultural differences in speech acts are common challenges in management involving Chinese and Western managers. Comparing four groups – Native-speaking Chinese, English-speaking Chinese, Chinese-speaking Westerners, and non-Chinese- speaking Westerners ...
Jan Ketil Arnulf +3 more
doaj +1 more source
Samhandling i samferdselsprosjekter [PDF]
, 2017 Denne rapporten presenterer resultater fra forskningsprosjektet «Samhandling i samferdselsprosjekter», som ble utført ved Senter for byggenæringen ved Handelshøyskolen BI fra september 2013 til desember 2016. Prosjektet har vært finansiert av partnerne i
Swärd, Anna
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