Results 11 to 20 of about 236,506 (251)

Obesity and the Risk of Low Bicarbonate: A Cohort StudyPlain-Language Summary

Kidney Medicine, 2021
Rationale & Objective: Acid retention may occur in the absence of overt metabolic acidosis; thus it is important to identify populations at risk.
Douglas C. Lambert, Matthew K. Abramowitz   +1 more
doaj   +1 more source

Heterologous expression and biochemical characterisation of the recombinant β-carbonic anhydrase (MpaCA) from the warm-blooded vertebrate pathogen malassezia pachydermatis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Warm-blooded animals may have Malassezia pachydermatis on healthy skin, but changes in the skin microenvironment or host defences induce this opportunistic commensal to become pathogenic.
Viviana De Luca, Andrea Angeli, Valeria Mazzone, Claudia Adelfio, Vincenzo Carginale, Andrea Scaloni, Fabrizio Carta, Silvia Selleri, Claudiu T. Supuran, Clemente Capasso   +9 more
doaj   +1 more source

Bicarbonate Evokes Reciprocal Changes in Intracellular Cyclic di-GMP and Cyclic AMP Levels in Pseudomonas aeruginosa

Biology, 2021
The formation of Pseudomonas aeruginosa biofilms in cystic fibrosis (CF) is one of the most common causes of morbidity and mortality in CF patients.
Kasidid Ruksakiet, Balázs Stercz, Gergő Tóth, Pongsiri Jaikumpun, Ilona Gróf, Roland Tengölics, Zsolt M. Lohinai, Péter Horváth, Mária A. Deli, Martin C. Steward, Orsolya Dobay, Ákos Zsembery   +11 more
doaj   +1 more source

Renal bicarbonate reabsorption during bicarbonate loading

Kidney International, 1980
To examine bicarbonate reabsorption at different GFR's, we varied the renal perfusion pressure in anesthetized dogs after inhibiting autoregulation by expanding extracellular volume and infusing ethacrynic acid. At a plasma bicarbonate concentration (PHCO3) of 28 +/- 1 mM, bicarbonate reabsorption varied in proportion to GFR (glomerulotubular balance).
Monclair, Tom, Mathisen, Øystein, Kiil, Fredrik   +2 more
openaire   +2 more sources

Bicarbonate and Ca2+ sensing modulators activate photoreceptor ROS-GC1 synergistically

Frontiers in Molecular Neuroscience, 2016
Photoreceptor ROS-GC1, a prototype subfamily member of the membrane guanylate cyclase family, is a central component of phototransduction. It is a single transmembrane-spanning protein, composed of modular blocks.
Teresa eDuda, Alexandre ePertzev, Clint L Makino, Rameshwar K Sharma   +3 more
doaj   +1 more source

Integrative signaling networks of membrane guanylate cyclases: Biochemistry and physiology

Frontiers in Molecular Neuroscience, 2016
This monograph presents a historical perspective of cornerstone developments on the biochemistry and physiology of mammalian membrane guanylate cyclases (MGCs), highlighting contributions made by the authors and their collaborators.
Rameshwar K Sharma, Teresa Duda, Clint L Makino   +2 more
doaj   +1 more source

Pancreatic ductal bicarbonate secretion: challenge of the acinar acid load

Frontiers in Physiology, 2011
Acinar and ductal cells of the exocrine pancreas form a close functional unit. Although most studies contain data either on acinar or ductal cells, an increasing number of evidence highlights the importance of the pancreatic acinar-ductal functional unit.
Peter eHegyi, Jozsef eMaléth, Viktória eVenglovecz, Zoltan eRakonczay   +3 more
doaj   +1 more source

Proximal Renal Tubular Acidosis Mediated by Mutations in NBCe1-A: Unraveling the Transporter’s Structure-Functional Properties

Frontiers in Physiology, 2013
NBCe1 belongs to the SLC4 family of base transporting membrane proteins that plays a significant role in renal, extrarenal, and systemic acid-base homeostasis.
Ira eKurtz, Quansheng eZhu
doaj   +1 more source

CFTR dysfunction leads to defective bacterial eradication on cystic fibrosis airways

Frontiers in Physiology
Dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel by genetic mutations causes the inherited disease cystic fibrosis (CF).
Min Wu, Jeng-Haur Chen
doaj   +1 more source

Randomized Trial of Dietary Acid Reduction and Acid-Base Status of Patients With CKD and Normal Estimated GFR

Kidney International Reports
Introduction: Modern acid-producing diets in patients with stage G3 to G5 chronic kidney disease (CKD) can cause severe acid accumulation with metabolic acidosis and less severe accumulation causing eubicarbonatemic acidosis in stages G2 to G3, each with
Nimrit Goraya, Nicolaos E. Madias, Jan Simoni, Maninder Kahlon, Nazan Aksan, Donald E. Wesson   +5 more
doaj   +1 more source